Use to diagnose and monitor diabetes mellitus and/or prediabetes. This assay may produce lower HbA1c results in patients with abnormal amounts of HbF.  Consider ordering Fructosamine as an alternative test for monitoring long-term glycemic control in these patients.

Blood cultures are incubated for five days, which is adequate for recovery of fastidious organisms including HACEK organisms. Requests for extended incubation times will be denied. First time positive bottles (within a seven-day period) will have molecular blood culture identification performed by multiplex PCR. This multiplex PCR assay detects ...

This panel contains  Cholesterol  LDL Cholesterol (calculated) High-Density Lipoprotein (HDL), Cholesterol Calculated Non-HDL Cholesterol Triglycerides

Preferred test for initial screening and monitoring of thyroid function

This is a qualitative molecular diagnostic test that aids in the diagnosis of COVID-19 infection by SARS-CoV-2.  

Intended for symptomatic patients, or patients with risk factors, suspected of urinary tract infection.

Preferred test to diagnose vitamin D insufficiency and monitor response to therapy.

Test includes reflex to free T4 for TSH results outside the reference range.

This is a multiplex molecular panel which detects the following organisms: Influenza A (including subtypes), Influenza B, RSV, SARS-CoV-2, Adenovirus, Seasonal Coronaviruses, Rhinovirus/Enterovirus, Human Metapneumovirus, Parainfluenza virus 1-4, Mycoplasma pneumoniae, and Chlamydia pneumoniae. For most patients with seasonal respiratory illnes...

Aid in the diagnosis of iron deficiency anemia and iron overload.

This is for Outreach Client only.

Preferred test to detect acute phase inflammation (eg, autoimmune diseases, connective tissue disease, rheumatoid arthritis, infection, or sepsis). DO NOT ORDER for cardiovascular disease (CVD) risk assessment. The correct test for CVD risk assessment is High Sensitivity C-Reactive Protein.

Aid in the diagnosis of iron deficiency anemia and iron overload.

An aid in the diagnosis of congestive heart failure.

This test is to aid in the diagnosis of patients with latent Mycobacterium tuberculosis infection. This test is effective in individuals who have received BCG vaccination.

MUST submit 2 separate urine specimens (one BD yellow-top urinalysis collection tube and one BD gray-top urine culture tube) For Northwell Core Lab, specimen will reflex to a routine urine culture if any one of the following criteria is present: 1. Positive nitrite 2. Positive leukocyte esterase 3. Bacteria >= Moderate 4. > 5 WBC/hpf Fo...

Nonspecific indicator of myopathies or other trauma, toxin, or drug-induced muscle injury. The recommended test for diagnosis and management of acute coronary syndrome is Troponin T, High Sensitivity.

This panel is intended for patients suspected of COVID-19 virus (SARS-CoV-2), Influenza A, Influenza B, and RSV (Respiratory syncytial virus).

Recommended test for diagnosis and management of acute coronary syndrome

Aids in diagnosis and monitoring of numerous renal and metabolic disorders(e.g., renal failure, gout, leukemia, psoriasis). Aids in monitoring patients receiving cytotoxic drugs.

This test is the first step of the Reverse Syphilis Screening algorithm. Positive Treponema pallidum antibody test results will reflex to RPR for confirmation. Discordant samples will be tested with an alternative Treponemal assay.

This assay is intended for the early detection of pregnancy by quantitative determination of the sum of human chorionic gonadotropin (hCG) plus the hCG β‑subunit in human serum and plasma.

This is a testing algorithm for the diagnosis of HCV infection. Positive antibody results will reflex to confirmation by molecular detection.

This test available for Hospitial patients only.

This test is a 4th Generation HIV screening assay used for the diagnosis of Human Immunodeficiency Virus (HIV) and tests for HIV p24 antigen as well as antibodies against both HIV-1 and HIV-2. All reactive HIV screens will reflex automatically to HIV-1/HIV-2 Antibody Supplemental testing to differentiate HIV-1 and HIV-2 antibodies. If supplement...

Aids in the detection of vitamin B12 or folate deficiency in individuals with macrocytic or unexplained anemia, or unexplained neurologic disease.

This test is recommended for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae.

This test qualitatively detects 14 High Risk HPV types and includes reflex to genotyping for types 16, 18, and 45.

This test aids in the diagnosis of acute Hepatitis B infection.

An important test for identifying early kidney disease in patients with diabetes or other risk factors (eg, hypertension).

Intended for semiquantitative detection of antibodies to SARS‑CoV‑2 spike protein. This test is intended for use as an aid in identifying individuals with an adaptive immune response to SARS‑CoV‑2, indicating recent/prior infection and/or COVID-19 vaccination.

This test is for the qualitative detection of MRSA and MSSA from anterior nasal swabs to aid in identification of individuals colonized by S. aureus.

Aids in the detection of folate deficiency.

Quantitative assay for total (free + complexed) PSA as an initial screening test for prostate cancer in conjunction with digital rectal exam.

Use to assess risk of progression to severe sepsis and septic shock in critically ill patients upon admission to ICU. Use in conjunction with other laboratory findings.

For the detection of Group A Streptococcus in throat cultures only.

Aids in initial diagnosis of systemic autoimmune rheumatic disease (i.e., connective tissue disease).

This test is available for Northwell Health hospital patients only.

This test aids in the identification of patients with an immune response to Hepatitis B virus either through infection or vaccination.

This test qualitatively detects 14 High Risk HPV types. This test does not reflex to HPV genotyping. To order HPV Screening with reflex to genotyping, order "Human Papillomavirus (HPV) High Risk Molecular Detection with Reflex to Genotyping".

This test is intended to aid in the diagnosis of bacterial vaginosis, Candida vulvovaginitis, or Trichomonias using nucleic acid hybridization. For more sensitive detection of the routine causes of vaginosis/vaginitis order "Vaginitis Panel NAAT (Bacterial Vaginosis, Candida species, and Trichomonas vaginalis) by nucleic acid ampl...

Aids in the workup of suspected rheumatoid arthritis or undifferentiated inflammatory arthritides. Consider ordering this test in conjunction with Cyclic Citrullinated Peptide (CCP) to increase specificity and sensitivity.

Testing performed at Northwell Rapid Response Laboratories

This test aids in the identification of patients with prior or recent Hepatitis B infection.

This test is recommended for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae from cervical cytology specimens.

Preferred initial screening test for Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency.

This test is intended for use as an aid in identifying individuals with an adaptive immune response to SARS‑CoV‑2, indicating recent or prior infection.

Test includes Thyroid Peroxidase (TPO) Antibody and Thyroglobulin Antibody

Aid in evaluating patients with clinical features or at-risk for systemic lupus erythematosus (SLE)

Recommended for routine testing for lead exposure.

This test is available for Northwell Health hospital patients only.

**Restricted to expedited maternal newborn testing, occupational exposure (source patients) and for      Emergency Department patients.**

Vitamin D, 25-Hydroxy is the preferred test to diagnose vitamin D insufficiency and monitor response to therapy. 1,25-Dihydroxy Vitamin D testing may be useful for evaluating calcium metabolism in individuals with hypercalcemia or renal failure in addition to Vitamin D, 25-Hydroxy testing.

For determination of immune status to Rubella virus.

Evaluate nonbound calcium, calcium metabolism, physiologically active calcium fraction, hyperparathyroidism, ectopic hyperparathyroidism. Occasionally useful when hypercalcemia coexists with abnormal protein state such as myeloma. Useful in assessing active calcium fraction in hypoproteinemia and acidosis when calcium is low.

For determination of immune status to VZV.

Nipple Discharge slides should be immediately fixed in a 70% alcohol vial. All other specimens should be submitted in a ThinPrep CytoLyt vial. Exact specimen source and laterality where applicable must be selected/specified. For more specific collection instructions see the Test Compendium. Specimen vials should be labeled with patient demogra...

Nipple Discharge slides should be immediately fixed in a 70% alcohol vial. All other specimens should be submitted in a ThinPrep CytoLyt vial. Exact specimen source and laterality where applicable must be selected/specified. For more specific collection instructions see the Test Compendium. Specimen vials should be labeled with patient demogra...

Highly specific serologic test to aid in the workup of suspected rheumatoid arthritis (RA) or undifferentiated inflammatory arthritides.

For respiratory cultures from sputum and tracheal aspirate sources only. Sputum sources are evaluated for acceptability by Gram stain. Unacceptable specimens will not be evaluated for culture growth.

Ova and Parasite Examination is used to detect gastrointestinal parasites including helminths, cestodes, and protozoa in preserved stool specimens. A complete exam includes microscopic evaluation of both a concentrated iodine-stained wet preparation and a permanent stained (Trichrome) preparation. Optimal sensitivity is obtained by collecting th...

Aids in the management of patients with monoclonal gammopathies. Use to detect and quantify serum monoclonal protein. Immunofixation is performed if patterns observed in protein electrophoresis are monoclonal or suspicious.

For monitoring HIV-1 viral load in known HIV-1 positive patients.

For determination of immune status to measles virus.

For bacterial culture of sterile body fluids, not including synovial fluid or CSF. This test includes Gram stain evaluation and aerobic/anaerobic bacterial cultures. Synovial fluid specimens should be ordered as "Joint Culture" and "Joint Fluid Pathogen Panel, Molecular Detection". Cerebrospinal fluid (CSF) specimens should be ordered as "CSF C...

This test includes quantitative serum immunoglobulins (IgA, IgG, IgM) and serum free light chains (free kappa and free lambda-light chains)

For more information on the interpretation of Lyme disease serology, please visit:https://www.youtube.com/watch?v=Dei-8na9wZUhttps://www.youtube.com/watch?v=LhF7vX5RynAhttps://www.aphl.org/aboutAPHL/publications/Documents/ID-2021-Lyme-Disease-Serologic-Testing-Reporting.pdf

For determination of immune status to HBV.

Evaluating individuals' response to ovarian cancer therapy. Aids in predicting recurrent ovarian cancer. This test is not useful for cancer detection screening in the normal population.

Preferred initial screening test to aid in the diagnosis of monoclonal gammopathies. This test includes serum protein electrophoresis, Immunofixation/Immunotyping, serum free light chains (free kappa and free lambda-light chains) and quantitative immunoglobulins (IgA, IgG, IgM)

This test is intended for use as an aid in the management of CMV in solid organ transplant patients and in hematopoietic stem cell transplant patients, as well as for monitoring CMV antiviral therapy.

Aid in evaluation of hyperinsulinemic hypoglycemia. Aid in assessment of the etiology of anion gap acidosis. Screen for suspected mitochondrial disorders.

Aid in the management of patients with non‑seminomatous germ cell tumors.

This test is intended to be used as an aid to the diagnosis of bacterial vaginosis (BV) in women with a clinical presentation consistent with this disorder. Detect the presence of Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, Candida lusitaniae, and Candida krusei DNA in vaginal samples as an aid to the diagnosi...

Serum Immunofixation/Immunotyping

Screening test for gestational diabetes mellitus. Perform a 50-g glucose load test (nonfasting), with plasma glucose measurement at 1 h post ingestion. This test is typically performed at 24–28 weeks of gestation in individuals not previously diagnosed with diabetes.

Aid in the evaluation of for suspected celiac disease.

Recommended test for the qualitative detection of fecal occult blood in feces. Aids in assessment of gastrointestinal (GI) bleeding, found in a number of gastrointestinal disorders (GI), e.g. colitis, polyps, and colorectal cancer.

For molecular detection of Trichomonas vaginalis from urogenital sources.

For serological determination of EBV VCA IgM, VCA IgG, EA IgG, and EBNA IgG.

For use as an adjunct to culture for the presumptive diagnosis of past or current Legionella infection. This test only detects antigen from Legionella pneumophila serogroup 1. For culture, order "Legionella Culture" on a lower respiratory specimen.

Aids in the evaluation of ANCA-associated vasculitis

This test aids in the diagnosis of C. difficile colitis. Do not order on patients hospitalized for more than three days. Stool specimens must be unformed/liquid.

An elevated concentration of homocysteine is an independent risk factor for cardiovascular disease. When used in conjunction with methylmalonic acid (MMA), these tests are useful to diagnose and monitor vitamin B12 (cobalamin) and folic acid deficiency and are often useful in evaluating macrocytosis (an elevated MCV, an erythrocytic index).

For the multiplexed molecular detection of multiple bacteria, viruses and parasites directly from stool samples in Cary-Blair transport media obtained from individuals with signs and/or symptoms of gastrointestinal infection. If Shigella, Salmonella, Vibrio, Yersinia, STEC or E. coli O157 are detected, culture will be performed. Antibiotic susce...

Serologic detection of recent or past parvovirus B19 infection This assay may be used to determine the serostatus of patients at risk for infection with parvovirus B19. Alongside clinical evaluation and other laboratory findings, results may be used to determine if the patient has recent or past infection with parvovirus B19.

For the detection of H. pylori infection.

For the assessment of thiamine deficiency

This test is for bacterial culture of superficial wounds. Only aerobic culture will be performed.

For the molecular detection of Chlamydia trachomatis and Neisseria gonorrhoeae from oropharyngeal specimens.

For determination of CMV IgG antibody avidity in patients with positive CMV IgG results, particularly those at risk for fetal complications during pregnancy.

This assay provides absolute cell counts and percentages for CD3+ T-cells, CD4 and CD8 T cell subsets,as well as CD4/CD8 ratio.

Aids in the assessment of glomerular filtration rate in patients for whom serum creatinine may be misleading, such as the very obese, elderly, or malnourished patients.

Measurement of cardiolipin antibodies can aid in the evaluation of patients with suspected cases of antiphospholipid syndrome

Useful in predicting risk of cardiovascular disease

Preferred test for the detection of Streptococci causing pharyngitis.

Aids in the evaluation of suspected celiac disease.

May aid in monitoring glucose control in patients with shortened red blood cell survival

Serum free light chains (kappa and lambda) with ratio

Monitor therapy and identify disease recurrence in individuals with a metastatic breast cancer diagnosis. Do not use for diagnosis or screening of breast cancer.

For detection of antibodies against Toxoplasma gondii.

This test is intended for monitoring HCV viral loads in patients with known HCV infection.  For diagnosis of new HCV infections, order "Hepatitis C Virus (HCV) Antibody, IgG with  Reflex to HCV Molecular Detection, Quantitative".

Aids in the diagnostic workup of hypoglycemia. Aids in diagnosis of factitious hypoglycemia due to surreptitious administration of insulin. Aids in the evaluation of possible insulinoma

For perinatal screening of Group B Streptococcus (GBS) by molecular methods.

For the molecular detection of Chlamydia trachomatis and Neisseria gonorrhoeae from rectal specimens.

This method measures the rate of clot formation after adding a high concentration of thrombin to citrated plasma. The fibrinogen activity is then derived from a standard curve relating the clotting time to plasma standards of known fibrinogen activity.

Gastrointestinal Pathogen Panel Molecular Detection is the preferred test for comprehensive evaluation of infectious diarrhea. Stool cultures are examined only for Salmonella, Shigella, Campylobacter, Aeromonas, Plesiomonas, Vibrio, E.coli O157 and Yersinia.

This test is for bacterial culture of deep or complex wounds (eg, diabetic foot wounds). Both aerobic and anaerobic culture will be performed.

For determination of immune status to Mumps virus.

Quantification of HBV DNA in serum of patients with chronic HBV infection (previously hepatitis B surface antigen-positive) Monitoring disease progression in chronic HBV infection and/or response to anti-HBV therapy

High in sarcoidosis, more often when the disease is active. Of value in assessing the response of sarcoidosis to corticosteroid therapy. Changes in serum ACE correlate with clinical status and results of gallium scans (which reflect presence and activity of inflammatory granulomatous lesions).

Serum methylmalonic acid (MMA) measurement is used to evaluate individuals with signs and symptoms associated with vitamin B12 deficiency or congenital methylmalonic academia.

For more information on the interpretation of Lyme disease serology, please visit: https://www.youtube.com/watch?v=Dei-8na9wZU https://www.youtube.com/watch?v=LhF7vX5RynA https://www.aphl.org/aboutAPHL/publications/Documents/ID-2021-Lyme-Disease-Serologic-Testing-Reporting.pdf

Streptococcus agalactiae (Group B) (GBS) has been recognized as the leading infectious cause of perinatal morbidity and mortality in the United States. Early onset neonatal disease results from transmission of GBS during labor and delivery from mother to infant. This can be characterized by septicemia, pneumonia, or meningitis and can result in ...

This test is intended to aid in the diagnosis of both pneumococcal meningitis and pneumococcal pneumonia in conjunction with culture. This test should not be used as a test of cure. The clinical utility of this test in pediatric patients has not been determined.

Aids in the diagnosis of antiphospholipid syndrome (APS).

Aids in the diagnosis of antiphospholipid syndrome (APS).

An in vitro diagnostic to aid in the diagnosis of inflammatory bowel disease (IBD), Crohn's disease, and ulcerative colitis, and to differentiate IBD from irritable bowel syndrome (IBS) in conjunction with other clinical and laboratory findings.

For monitoring of BK virus viral loads in patient blood specimens.

For determination of immune status to measles, mumps, rubella, and VZV.

Herpes Simplex Virus 1/2 Antibody (IgM), IFA with Reflex to Titer, Serum - HSV IgM is detectable in serum from >90% of patients with primary HSV infection; However, HSV IgM is also found in 30% of patients with reactivated HSV.

Lp(a) is an independent prospective risk factor for coronary heart disease. Lp(a) determination is intended for use in conjunction with clinical evaluation, patient risk assessment, and other lipid tests to evaluate disorders of lipid metabolism and to assess coronary heart disease in specific populations.

The measurement of thyroid stimulating autoantibodies, in conjunction with other clinical and laboratory findings, is used as an aid in the diagnosis of patients suspected of having Graves' disease.  

This test detect antibodies to nuclear antigens by Immunofluorescence Assay (IFA) with pattern identification and titers. Positive IFA results will reflex to specific antibody detection against • dsDNA • Chromatin • Ribosomal P • Sjogren's SSA-A (Ro)• Sjogren's SS-B (La)• Smith (Sm) • RNP • Scl-70 • J...

Test Includes Amphetamine; barbiturate; benzodiazepines; cocaine; methadone; opiates; oxycodone/oxymorphone; phencyclidine (PCP); fentanyl; marijuana (THC) metabolite.

Recommended initial test to evaluate for suspected celiac disease (CD) in IgA-competent individuals. May aid in monitoring therapeutic response to a gluten-free diet in individuals with confirmed CD.

  Monitor exposure to zinc; evaluate suspected nutritional inadequacy, especially in enteral or parental nutrition, critically ill or burn patients; cases of diabetes or delayed wound healing; growth retardation; follow therapy, for example when higher intravenous zinc doses are used to balance excessive ongoing GI losses in long-term t...

Differential diagnosis of hypervitaminosis A. A combination of a low serum carotene level and a low vitamin A suggests inadequate vitamin A nutrition.

This assay provides absolute cell counts and percentages for CD3+ T-cells, CD4 and CD8 T cell subsets, CD19+ B-cells, CD16/CD56 natural killer cells,as well as CD4/CD8 ratio.

May be used as initial screening test in Wilson disease or copper transport disorders.

Serum antibody panel for suspected common tickborne diseases: Lyme disease, anaplasmosis, ehrlichiosis, and babesiosis. For information on the specific diseases, see the individual test IDs.

Northeast Regional Respiratory Allergen profile.

Aids in the diagnosis of antiphospholipid syndrome (APS)

Detect vitamin B6 deficiency  

Testing for Northwell RRL patients only

Serum Ketone has been discontinued at CFAM for all Outreach patients Still available for Hospital Rapid Response Laboratories Outreach Only- Please order Betahydroxybutarte (BOHB)

Aids in the diagnosis of Graves' disease (autoimmune hyperthyroidism)

For determination of immune status to measles, mumps, and rubella viruses.

For in vitro diagnostic use as an indicator of human bone resorption. This test may be used as an aid in monitoring bone resorption changes of antiresorptive therapies in postmenopausal women, individuals with osteopenia, and in predicting skeletal response (bone mineral density) in postmenopausal women undergoing antiresorptive therapies.

SHBG is a major transport protein for sex steroids (e.g., testosterone and estradiol). Measurement of SHBG concentration is useful as an aid in diagnosis of androgen disorders. Additionally, SHBG may be useful in the evaluation of infertility and investigation of suspected cases of polycystic ovarian syndrome (PCOS)

Workup of individuals with suspected disorders such as familial chronic obstructive lung disease

Markedly elevated in patients with congenital adrenal hyperplasia; evaluate hirsutism and/or infertility; assess or rule out certain adrenal or ovarian tumors with endocrine activity              

Aiding in the diagnosis of invasive fungal infections caused by various fungi, including Aspergillus species, Fusarium species, Candida species, 

Aids in the diagnosis of adrenal insufficiency and determining the presence of anterior pituitary tumors.

Quantitative measurement of skeletal alkaline phosphatase to be used as an aid in the management of patients with Paget disease and osteoporosis

The detection of LKM-1 antibodies is an aid in the diagnosis of autoimmune hepatitis, type 2 (AIH-2). LKM antibodies are markers of AIH-2 which usually begins in childhood and generally affects children younger than 18 years of age. LKM antibodies are associated with a more serious progression of the disease.

Aids in evaluation of ANCA-associated vasculitis.

Evaluate muscle wasting process. High levels are found in progressive Duchenne muscular dystrophy (MD).

This test, along with H. pylori urea breath testing is for the diagnosis of infection with H. pylori.

Evaluate vitamin E deficiency in hemolytic disease in premature infants, and neuromuscular disease in infants (and adults) with chronic cholestasis; evaluate patients on long-term parenteral nutrition; patients with malignancy or malabsorption (eg, patients with cystic fibrosis, cases of intestinal bypass surgery); investigate brown-bowel sy...

Evaluation response to therapy for syphilis.

CSF culture is for the culture of common cerebrospinal fluid pathogens. All culture orders include Gram stain. For optimal sensitivity, "CSF Pathogen Panel Molecular Detection" should be ordered alongside CSF Culture.

Evaluation of catecholamine-secreting tumors of the adrenal medulla (pheochromocytomas) and extra-adrenal sympathetic and para-sympathetic paragangliomas.

IgG is the most abundant serum immunoglobulin in healthy individuals and is comprised of 4 subclasses (i.e., IgG1, IgG2, IgG3 and IgG4). Of total IgG, approximately 65% is IgG1, 25% is IgG2, 6% is IgG3, and 4% is IgG4. Measurement of IgG subclasses is useful when evaluating patients with suspected humoral immunodeficiency.

Diagnosis and monitoring treatment of liver, bone, intestinal, and parathyroid diseases

Biomarker associated with ethanol consumption; may be helpful in monitoring alcohol abstinence. PEth is useful for verifying abstinence or use of ethanol especially in liver transplant candidates/patients

For routine throat cultures, order "Group A Streptococcus Culture, Throat". Ear, Nose, and Throat Culture is intended for the comprehensive workup of sinusitis and related infections.

It is used, along with serum ceruloplasmin and urine copper, to test for Wilson's disease and (more often) in monitoring the nutritional adequacy of parenteral or enteral nutrition, especially when copper deficiency may be suspected because of ongoing gastrointestinal losses of the element (see table). The test is done in suspected copper toxici...

To be ordered Only if Platelet Count from Lavender top tube is clumped.

Evaluating patients suspected of having celiac disease, including patients with compatible symptoms, patients with atypical symptoms, and individuals at increased risk (family history, previous diagnosis with associated disease)
 

Measurement of serum AMH concentration is clinically used for the assessment of ovarian reserve in women during the evaluation of infertility and/or assisted reproduction protocols.

For routine throat cultures, order "Group A Streptococcus Culture, Throat". The "Throat Culture" order will report all beta-hemolytic Streptococci and Arcanobacterium.

For recovery of organisms frequently associated with genital infections.

The serum concentration of a drug is measured as a guide to individuation of therapy. 

This assay is intended to be used as an aid to the diagnosis of infections caused by Borrelia burgdorferi sensu stricto, the etiologic agent of Lyme disease in the United States. It is not intended to be used for testing patients suspected of acquiring Lyme disease outside of the US.

Evaluate for ovarian estrogen producing tumor in the premenarcheal and postmenopausal female; evaluate estrogen excess in males. Estrogen analysis may be helpful in establishing time of ovulation and optimal time for conception. Serial samples must be collected over several days to evaluate baseline and peak total estrogen levels.

This test is used as an aid in the diagnosis of congenital CMV infection in newborns less than 21 days of age.

Can be used for the diagnosis or the exclusion of exocrine pancreatic insufficiency, which may be associated with chronic pancreatitis, cystic fibrosis, carcinoma of the pancreas, diabetes mellitus type 1 (insulin-dependent diabetes mellitus), Shwachman-Diamond syndrome, and other etiologies of pancreatic insufficiency.

This test is not intended for the diagnosis of HIV. It is intended as a confirmatory assay following a reactive HIV 4th generation screening test. For HIV diagnosis, order "Human Immunodeficiency Virus (HIV) Antigen/Antibody Combination Screen with Reflex to Confirmation Testing".

Intended for the multiplex PCR detection of multiple bacterial, viral, and fungal pathogens from cerebrospinal fluid in patients suspected of  having encephalitis/meningitis. Targets include: Escherichia coli K1, Haemophilus influenzae, Listeria monocytogenes, Neisseria meningitidis  (encapsulated), Streptococcus agalactiae, Strep...

Confirmation and characterization of protein S (PS) congenital deficiency
 
 

This test detects antigens produced by C. difficile: GDH and Toxin A/B. Only liquid stool specimens are acceptable. Formed stool will be rejected. 

Assessing susceptibility to autoimmune (type 1, insulin-dependent) diabetes mellitus and related endocrine disorders (eg, thyroiditis and pernicious anemia) Distinguishing between patients with type 1 and type 2 diabetes Confirming a diagnosis of stiff-man syndrome, autoimmune encephalitis, autoimmune ataxia, brain stem encephalitis, autoimmun...

Evaluate the contribution of the isoforms of ALP from liver, bone, and bowel to total ALP; investigate elevations of ALP to determine the tissue of origin
 

This test is intended as an aid in the diagnosis of anemias and polycythemias. With the advent of the administration of recombinant erythropoietin as a biologic therapy to increase red blood cell mass, an erythropoietin assay may be used also to aid in the prediction and monitoring of response to recombinant erythropoietin treatment of anemia.

Evaluate suspected drug-induced lupus. Negative results do not rule out drug-induced lupus.

This test is intended to be used as an aid to the diagnosis of bacterial vaginosis (BV) in women with a clinical presentation consistent with this disorder. Detect the presence of Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, Candida lusitaniae, and Candida krusei DNA in vaginal samples as an aid to the diagnosis ...

This test is a qualitative molecular for the detection of HCV in blood.

The presence of RNA polymerase III IgG antibody, when considered in conjunction with other laboratory and clinical findings, is an aid in the diagnosis of systemic sclerosis (SSc) with increased incidence of skin involvement and renal crisis with the diffuse cutaneous form of SSc.

AVISE CTD is an advanced autoimmune rheumatic disease test specifically designed to aid physicians in the differential diagnosis of systemic lupus erythematosus (SLE). AVISE CTD is the only diagnostic test powered by patented Cell-Bound Complement Activation Products (CB-CAPs), stable biomarkers of complement activation, to help physicians bette...

Aid in the evaluation of unexplained hypercalcemia, particularly in suspected hypercalcemia of malignancy.

Mayo test code FMYO3 The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of disorders characterized by muscle weakness, resulting from chronic muscle inflammation of unknown cause. Patients with IIM have a variety of autoantibodies with various clinical utilities that fall into two main groups.

Establish the diagnosis of Ureaplasma urealyticum infection in suspected cases of urethritis and cervicitis

This is for Transplant only! send samples to Renal Transplant                             Att: Leandra Osborne                             400 Community Drive

Ristocetin Co-Factor

Therapeutic monitoring of Lamotrigine

Measuring Low Molecular heparin concentration: -In patients treated with low-molecular-weight heparin preparations (Lovenox(Enoxaparin)) -In the presence of prolonged baseline activated partial thromboplastin time (APTT) (eg, lupus anticoagulant, "contact factor" deficiency, etc)

The test is useful in the diagnosis of spotted fever group rickettsial infections.

Aid in the diagnosis of autoimmune hepatitis (AIH)  

Useful if Giemsa stain is negative but high suspicion of babesiosis exists. Will not detect B. duncani or strain MO-1 Screening assay for Babesia microti infection or exposure

The respiratory tract begins with the nasal or oral passages, which serve to humidify inspired air, and extends past the nasopharynx and oropharynx to the trachea and then into the lungs. The trachea divides into bronchi, which subdivide into bronchioles, the smallest branches of which terminate in the alveoli. Upper respiratory specimens includ...

Evaluate the enterohepatic cycle consisting of the biliary system, intestine, portal circulation, and hepatocytes.

This test measures total tryptase (alpha and beta tryptase). It is intended for in vitro diagnostic use as an aid in the clinical diagnosis of patients with a suspicion of systemic mastocytosis in conjunction with other clinical and laboratory findings.

Qualitative determination of IgG antibodies to Strongyloides ratti in human sera

This is only for Lenox Hill Hospital clients

Screen patients who may be at risk for heart disease and stroke To diagnose and monitor vitamin B12 (cobalamin) deficiency.

Confirm the presence of precipitating antibodies to Aspergillus

Serologic test to aid in the diagnosis of invasive Aspergillosis.

For isolation of MRSA/MSSA only

Cryoglobulins may be divided into three classes. Type I are monoclonal immunoglobulins and are usually associated with lymphoproliferative disorders. Type II are mixtures of a monoclonal IgM and polyclonal IgG, and are associated with macroglobulinemia and chronic active hepatitis. Type III are mixtures of polyclonal IgM and polyclonal IgG. Thes...

Detection and semi-quantitation of IgG and IgM antibodies and Anaplasma phagocytophilum and Ehrlichia chaffeensis as an aid in the diagnosis of ehrlichiosis  

This test detects two antigens produced by C. difficile: GDH and Toxin A/B.  This test reflexes to confirmation by molecular detection for C. difficile toxin. Formed stools will be rejected.

Anti-GBM antibodies (glomerular basal membrane; Goodpasture Antigen) are important for the diagnosis of glomerulonephritis, which may be accompanied by pulmonary hemorrhage (Goodpasture pulmo-renal Syndrome). Due to clinical symptoms similar with systemic vasculitis, it is appropriate to concurrently carry out tests for anti-GBM and antineutroph...

Verifi Prenatal Tests safely and noninvasively screen for the most common chromosomal aneuploidies as early as 10 weeks gestation using a single maternal blood draw. The Verifi Prenatal Test is a non-invasive screening option for chromosomes 13, 18, and 21, and fetal sex chromosome aneuploidies in both singleton and twin pregnancies

AVISE SLE Monitor is an advanced SLE monitoring test comprised of six specialized biomarkers including patented EC4d and PC4d, to help assess patients with SLE.

This test is being discontinued Please order INFLIXIMAB Serum concentrations of IFX may vary among equally dosed patients which can ultimately affect patient outcomes. Suboptimal levels of IFX have been linked to lower response rates in IBD patients. Furthermore, some patients may develop immunogenicity to IFX by producing antibodies to In...

Definitive analysis of hereditary α1-antitrypsin deficiency, which is associated with chronic obstructive pulmonary disease (COPD) (panacinar emphysema), hepatic cirrhosis, and hepatoma. Cholestasis with neonatal hepatitis is found in a minority of neonates with α1AT deficiency.
 

The AFP-L3% assay is intended for use in the assessment of risk for the development of hepatocellular carcinoma (HCC) in patients with chronic liver diseases

Aiding in the distinction between the myeloproliferative neoplasm polycythemia vera and other secondary erythrocytosis.

Specimen should be collected approximately between 4:00 PM - 8:00 PM

For the assessment of vitamin K deficiency. Vitamin K deficiency may be induced by obstructive liver disease, obstructive icterus, malabsorption due to celiac disease, pancreatitis, diarrhea, and antibiotic abuse; may be used to treat blood clotting disorders, bone metabolism disorders, and hemorrhagic disorders of newborns.

Detects zinc transporter 8 autoantibodies (ZnT8), an autoimmune diabetes marker that is instrumental in the diagnosis of new-onset type 1 diabetes

The anti-PLA2R ELISA (IgG) test kit is intended for the qualitative or semiquantitative determination of IgG class autoantibodies against phospholipase A2 receptor (PLA2R) in human serum.1 It is used as an aid in the diagnosis of primary membranous glomerulonephritis (pMGN), in conjunction with other laboratory and clinical findings.
Limitat...

 Lacosamide is an antiepileptic medication. Monitoring the serum concentration is beneficial to ensure compliance with drug therapy.

Riboflavin deficiency is known as pellagra, usually found in those who do not consume a diet rich in organ meats, leafy greens, and whole grains. It is seen in elderly, alcoholics, those with chronic liver disease, and those on total parenteral nutrition. Deficiency may be associated with severe lactic acidosis, especially in HIV patients on tri...

Low levels of fibrinogen are associated with bleeding most commonly secondary to liver disease or Disseminated Intravascular Coagulation (DIC).

Oxcarbazepine is an antiepileptic drug, indicated for use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults with epilepsy. It is used in adjunctive therapy in epileptic children between the ages of four and 16.

Oligoclonal Bands (IgG), CSF - Oligoclonal bands are present in the CSF of more than 85% of patients with clinically definite multiple sclerosis (MS). To distinguish between oligoclonal bands in the CSF due to a peripheral gammopathy and oligoclonal bands due to local production in the CNS, serum and CSF should be tested simultaneously. Oligoclo...

Primarily for research and to support attempts to understand the pathogenesis of immune, infectious, allergic, or inflammatory disorders.

Folate levels have diagnostic significance in nutritional deficiencies, especially in cases of severe alcoholism, function damage to the upper third of small bowel, pregnancy and various forms of megoblastic anemia. Since serum folate levels are subject to rapid changes reflecting diet and absorption, RBC folate may be a better diagnostic t...

Detecting heparin-dependent platelet activating antibodies implicated in the pathogenesis of heparin-induced thrombocytopenia

Demonstrate acute infection with measles virus; differential diagnosis of a pregnant female exposed to or presenting with a rash

Assessing muscle damage from any cause

Mayo code ENS2 Evaluating new onset encephalopathy (noninfectious or metabolic) comprising confusional states, psychosis, delirium, memory loss, hallucinations, movement disorders, sensory or motor complaints, seizures, dyssomnias, ataxias, nausea, vomiting, inappropriate antidiuresis, coma, dysautonomias, or hypoventilation in serum specimens ...

Evaluating patients suspected of acute anaplasmosis or ehrlichiosis This test should not be used for screening asymptomatic individuals.

This molecular blood test is intended for the diagnosis of disseminated or severe infections by HSV-1 and HSV-2 in neonates and other high-risk patients.

Assessing the IgG antibody response to active immunization with nonconjugated, 23-valent vaccines Assessing the IgG antibody response to active immunization with conjugated 13-valent, 15-valent and  20-valent pneumococcal vaccines Determining the ability of an individual to produce an antibody response to polysaccharide antigens, as  p...

Serum and spinal fluid are required

Androstenedione (also known as 4-androstenedione and δ4-androstenedione) is a 19-carbon steroid hormone produced in the adrenal glands and the gonads that is the common precursor in the biochemical pathway that produces the androgen testosterone and the estrogens estrone and estradiol.1-7 Androstenedione has approximately one tenth of the and...

14-3-3 eta protein is a joint-derived, proinflammatory mediator that is implicated in the joint erosion process and pathogenesis of RA. Serum 14-3-3 eta is elevated in both early and established RA. 14-3-3 eta is highly specific for RA. Serum 14-3-3 eta may be especially helpful in identifying patients with early RA where it provides a 15% incr...

Intrinsic factor is a glycoprotein (produced by the parietal cells of the stomach) that is required for the absorption of vitamin B12 from the diet.1 During digestion, stomach acids dissociate B12 from food and intrinsic factor binds to it and allows it to be absorbed in the small intestine. Conditions that impair intrinsic factor production lea...

Provides infliximab drug concentration levels as well as levels of anti-infliximab antibodies. In the absence of anti-infliximab antibodies, the infliximab drug level typically reflects the total infliximab concentration in serum. In the presence of anti-infliximab antibodies, the infliximab drug level typically reflects the antibody-u...

Evaluate bone disease. Increased levels of osteocalcin are found in bone diseases characterized by increased bone turnover. Osteocalcin has been found to be elevated in Paget disease of the bone, cancer accompanied by bone metastases, primary hyperparathyroidism and renal osteodystrophy. Osteocalcin levels may serve as useful index in evaluating...

Managing patients with recurrent renal calculi (kidney stones) The composition of urinary stones may vary from a simple crystal to a complex mixture containing several different species of crystals. The composition of the nidus (center) may be entirely different from that of the peripheral layers. Eighty percent of patients with kidney stones ...

Hepatitis E causes an acute, self-limiting infection. Antibody IgG is detected after Antibody IgM is detected, typically 1 month post-infection.  Antibody IgM is detected 1-4 weeks post-infection. This is the preferred test for diagnosing Hepatitis E infection.

Aids in follow-up or surveillance of patients with known or treated carcinoid tumors. May be useful in monitoring nonsecretory sympathetic and parasympathetic neuroendocrine tumors.

Clozapine a tricyclic dibenzodiazepine derivative atypical antipsychotic agent used for treatment resistant schizophrenia and reducing suicidal behavior in schizophrenia and schizoaffective disorder

Assess immunity against tetanus by determining levels of circulating antibodies to tetanus toxin or to measure the immune response, postvaccination, in individuals suspected of immunodeficiency disorders

Hypersensitivity pneumonitis (HP) or extrinsic allergic alveolitis is a diffuse inflammation of the peripheral airways of the lung. It is caused by repeated inhalation of a variety of organic dust allergens including animal and vegetable products, fungi and bacteria. Frequently the etiologic agents are associated with the patient's occupational ...

Plasma catecholamines with urinary metanephrines and VMA are a recommended test battery for pheochromocytoma.3 Others recommend plasma catecholamines when urinary collections are not diagnostic. Work up multiple endocrine adenomatosis, type II. Used also in diagnosis of disorders related to the nervous system and in assessment of resuscitation

Determining acute-phase infection with rubeola (measles) virus using IgM antibody testing Aiding in the identification of nonimmune individuals through IgM antibody testing

Antibodies to Saccharomyces cerevisiae are found in approximately 75% of patients with Crohn's disease, 15% of patients with ulcerative colitis, and 5% of the healthy population. High titers of antibody increase the likelihood of disease, and specifically Crohn's disease, and are associated with more aggressive disease.

Diagnose myocardial infarction (MI).

Aid in diagnosis or monitoring of IgG4-related disease.

Screening for Cushing syndrome Diagnosis of Cushing syndrome in patients presenting with symptoms or signs suggestive of the disease

Diagnosis of past exposure to hepatitis E virus

This assay is the primary test for confirming the diagnosis of acquired myasthenia gravis.
 

Measurement of sTfR is used to diagnose iron deficiency in individuals with chronic disease (inflammatory diseases, infections, malignancies), many of whom are anemic.

This syphilis VDRL is a nontreponemal assay used to aid in the diagnosis of neurosyphilis.

Assess the function of the antral follicles of the ovaries in women or the Sertoli cells of the testes in men
 

Monitor maternal blood for environmental lead exposure.

This test is for perinatal screening of Group B Streptococcus (GBS) in women with severe penicillin allergy.

Babesia microti, Molecular Detection is the recommended test for all suspected cases of babesiosis. This assay provides significantly faster turnaround time and more accurate results than traditional blood smears. If parasite quantification is required, “Parasitemia, Blood” should be ordered with “Babesia microti, Molecular Detection", or on ...

The Verifi Prenatal Test with Microdeletions is a non-invasive screening option for chromosomes 13, 18, and 21, and fetal sex chromosome aneuploidies in both singleton and twin pregnancies. It is a non-invasive screening option for standard chromosome aneuploidies, certain microdeletions, and all autosomes. Expanded panels (microdeletions or all...

HSV culture is useful in verifying HSV is present within the vesicles.

 
An in vitro diagnostic aid to distinguish patients with active inflammatory bowel disease (IBD) from those with inactive IBD, as well as from noninflammatory irritable bowel syndrome (IBS).
 

Test includes: Androstenedione, DHEA-S, 17-OH-Progesterone, Testosterone

The Gram stain is a rapid, preliminary test to assess the quality of specimens, identify bacterial infections, and to guide initial antibacterial therapy. NOTES: • Specimen source is required on request form for processing. • Gram Stain is automatically included when a culture is ordered for the following sources: body fluid, CSF, tissue, bronc...

Evaluate adrenal carcinomas that frequently secrete large amounts of DHEA

This test is a latex-enhanced, immunoassay that provides ultrasensitive detection and quantitation of free light chains (FLCs) in serum or urine earlier than electrophoresis. It is an aid in the diagnosis and treatment of multiple myeloma, lymphocytic neoplasms, Waldenstroms macroglobulinemia, and connective tissue diseases, such as systemic lup...

Aids in the diagnosis of celiac disease. The HLA DQ Association test provides genotyping for detection of HLA-DQ2 (DQA1*05:01 or 05:05 and DQB1*02:01 or 02:02) and HLA-DQ8 (DQB1*03:02). Patients with DQ2, half DQ2 and/or DQ8 are predisposed to celiac disease. A negative result essentially rules out celiac disease. In addition to DQ2 and DQ8 stat...

Aiding in the diagnosis of tularemia caused by Francisella tularensis This test should not be used as a test of cure as it is not quantitative. Patients may remain seropositive for months to years following resolution of disease.

PHII is intraoperative PTH and can only be done via the OR at the hospital. Do not order for Outreach.

Diagnosing parvovirus B19 infection in plasma specimens

Monitoring whole blood sirolimus concentration during therapy, particularly in individuals coadministered CYP3A4 substrates, inhibitors, or inducers   Adjusting dose to optimize immunosuppression while minimizing toxicity   Evaluating patient compliance

To aid in the diagnosis of suspected septic arthritis and prosthetic joint infection. Acceptable specimen types include synovial fluid as well as bone/tissue from joint sources. Cultures will be held for 14 days for potential growth of Cutibacterium (previously Propionibacterium) species. For rapid diagnosis of the most common pathogens from syn...

Preferred screening test for Cushing syndrome Diagnosis of pseudo-hyperaldosteronism due to excessive licorice consumption Test may not be useful in the evaluation of adrenal insufficiency

Determination of TPMT levels that may be associated with toxicity of anticancer and anti-inflammatory drugs

Aid in the diagnosis of atypical pneumonia, which is a cause of community-acquired pneumonia.

May be useful in the comprehensive evaluation of patients with autoimmune neuropathies. Test by itself is not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

Hepatitis D Virus (HDV) infection occurs in association with HBV infection. A positive result for HDV total antibody may indicate either acute or chronic HDV infection.

Dihydrotestosterone and dihydrotestosterone/ratio may be used for differential diagnosis of diseases of sexual differentiation (DSD). DHT levels may be inappropriately low compared to testosterone levels in 5a-reductase deficiency. It is recommended by guidelines to measure the ratio of testosterone to DHT.
DHT levels may also be monitored t...

Monitor exposure to arsenic, lead, mercury, and cadmium

Free and weakly bound testosterone (FWBT), also referred to as bioavailable testosterone, is thought to reflect an individual's biologically active, circulating testosterone. FWBT includes free testosterone and testosterone that is bound to albumin.

Use to detect in vivo coating of red blood cells (RBCs) with  immunoglobulin and complement degradation products on the patient's RBCs. Useful for antibody identification and evaluation of transfusion reactions, hemolytic disease of the fetus and newborn (HDFN), and autoimmune hemolytic anemia associated with disease and/or drugs.

Monitor hematopoietic reconstitution following allogeneic bone marrow transplantation.
• Monitor effects of post-transplant therapies.
• Monitor minimal residual disease.
               • Measure chimerism in cellular subpopulations
Sample must be received immediately todeliver to the reference labwithin 24 hours of collection an...

Detect resistance of HIV-1 to protease, reverse transcriptase, and integrase inhibitors in cell-associated viral DNA.   This procedure should be used for patients with documented HIV-1 infection and undetectable viral load or low level viremia

A wide variety of microorganisms that reside on the skin and mucous membranes of the body, as well as those found in the environment, can cause skin and soft tissue infection. The organisms enter the body through breaks in the skin or mucous membranes, through wounds made by trauma or bites (exogenous) or a complication of surgery or foreign bod...

Intended to detect travel-associated blood parasites. For more rapid and sensitive detection of Babesia species, order "Babesia microti Molecular Detection".

Patients with a chronic form of urticaria who are positive (> 10) with the CU index® have an autoimmune basis for their disease. A positive result does not indicate which autoantibody (anti-IgE, anti-FceRI or anti-FceRII) is present.

Elecsys IL-6 immunoassay is an in-vitro diagnostic test for the quantitative determination of IL-6 (interleukin-6) in human serum and plasma.1,2 This assay is used to assist in identifying severe inflammatory response in patients with confirmed COVID-19 illness to aid in determining the risk of intubation with mechanical ventilation, in conjunct...

This test can be used as an aid in the diagnosis of certain autoimmune thrombotic disorders, such as antiphospholipid syndrome (aPS). Antibodies to PS/PT correlate with the presence of lupus anticoagulants (LA), and this test may be useful in cases with difficult LA test interpretation. This assay also may assist in the determination of risk for...

This assay is for the in vitro measurement of specific IgG antibodies against Haemophilus influenzae.

Confirmation of a clinical diagnosis Differentiation between de novo and familial cases Improved recurrence risk and prognosis

Serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology,  especially those with known risk factors for cancer Directing a focused search for cancer Investigating neurological symptoms that appear during, or after, cancer therapy and are not explainable by metastasis Differentiating autoi...

Measurement of Acetylcholine Receptor (AChR)-blocking Antibodies in serum

Detect Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma spp

Line blot, CSF; analysis and interpretation for IgG-specific and IgM-specific antibodies

Diagnose myasthenia gravis (MG); monitor response to treatment of myasthenia gravis

Vesicular specimens collected from persons infected with a non-variola Orthopoxvirus (such as vaccinia, monkeypox, or cowpox) are expected to  produce a positive result with this assay.

Must draw both a Lavender and Gold top tube for this assay Combines serologic, genetic, and inflammation markers to help differentiate IBD vs non-IBD and ulcerative colitis vs Crohn’s disease. This test aids healthcare providers in differentiating IBD vs non-IBD and CD vs UC in one comprehensive blood test. This assay includes 9 serological...

Evaluation of osteoporosis and assessment of antiresorptive therapy

Quantitative EBV DNA PCR can be used to aid in the early diagnosis of PTLD, track the course of the disease, and monitor response to treatment.

Monitor drug levels for optimal therapy

This test is a noninvasive assessment of liver status in patients with nonalcoholic fatty liver disease (NAFLD). Limitations NASH FibroSure® is recommended for patients with suspected nonalcoholic fatty liver disease. It is not recommended for patient with other  liver diseases. It is also not recommended in patients with Gilbert diseas...

Everolimus is a proliferation signal inhibitor that prevents allograft rejection. It exerts its immunosuppressive effect by in hibiting the proliferation, and thus clonal expansion, of antigen-activated T cells, which is driven by T-cell-specific interleukins. 

This test is intended to be used as an aid to the diagnosis of bacterial vaginosis (BV) in women with a clinical presentation consistent  with this disorder. Used to detect the presence of Candida albicans and Candida glabrata DNA in vaginal samples as  an aid to the diagnosis of vulvovaginal candidiasis in symptomatic women. Also used...

Monitor selenium deficiency and occupational exposure

Assist in diagnosing multiple sclerosis; determine whether an MS patient is having an active demyelinating episode; determine whether active demyelination is occurring in patients being treated by intrathecal chemotherapy or radiation therapy for neoplastic diseases involving the central nervous system; diagnose acute brain tissue destruction in...

Measurement of vitamin B3 level as nicotinic acid and nicotinamide.

Detection of NMO/APQ4-IgG allows distinction of NMOSD from MS and is indicative of a relapsing disease, mandating initiation of immunosuppression, even after the first attack, thereby reducing attack frequency and disability in the future.

 
Aid in the diagnosis of antibiotic-associated colitis
 

Assess immunity against diphtheria by determining levels of circulating antibodies to diphtheria toxin or to measure the immune response, postvaccination, in individuals suspected of immunodeficiency disorders

Monitor antiadalimumab therapy for individuals with Crohn's disease, inflammatory bowel disease, ulcerative colitis, rheumatoid arthritis, or other autoimmune conditions. This test provides adalimumab drug concentration levels as well as the level of antiadalimumab antibodies.

Aiding in detecting  in urine from patients with disseminated histoplasmosis. 

- Detection of antibodies to muscle-specific receptor tyrosine kinase (MuSK) (titer test).

MAG, Western Blot with reflexes is useful in detecting antibodies associated with autoimmune peripheral neuropathy.

Measurement of Dexamethasone is useful in assuring compliance with Dexamethasone treatment and documenting adequate dosing during such procedures as the Dexamethasone Suppression Test used in the differential diagnosis of Cushing's syndrome.

Confirm the diagnosis of carotenoderma; detect fat malabsorption; depressed carotene levels may be found in cases of steatorrhea.

Therapeutic Drug Management

Qualitative detection of human T-cell lymphotropic virus types I and II (HTLV-I and HTLV-II)-specific antibodies with confirmation and differentiation between HTLV-I and HTLV-II infection

Aids in the diagnosis of alpha-Gal associated meat allergy in which individuals who have been bitten by ticks of the Ixodidae family become sensitized to the carbohydrate determinant galactose-α-1,3-galactose (α-Gal). A distinctive feature of this allergy is the delayed onset of symptoms, which occurs 2-6 hours after eating meat. The delayed sy...

Diagnostic for  Thrombotic Thrombocytopenic Purpura (TTP) 

Clinical distinction of type 1 from type 2 diabetes mellitus
 
Identification of individuals at risk of type 1 diabetes (including high-risk relatives of patients with diabetes)
 

Vectra® DA measures the concentration of 12 serum proteins. An algorithm is applied to these concentrations to calculate a quantitate disease activity score ranging from 1 to 100. Test results are intended to aid in the assessment of disease activity in RA patients when used in conjunction with standard clinical assessment. This test is not inte...

High Grade (Gleason 7+) Prostate Cancer Risk Evaluation   Limitation an Exclusions for the 4Kscore Do not use this test for a patient:   1) With a previous diagnosis of prostate cancer   2) That has received a DRE in a previous 96 hours (4Days) before phlebotomy. A DRE performed after phlebotomy is acceptable.   3)...

This test is indicated for use as an aid to the diagnosis of West Nile virus encephalitis.
 

Diagnosis of hereditary angioedema Monitoring levels of C1 esterase inhibitor in response to therapy

Evaluating new onset encephalopathy (noninfectious or metabolic) comprising confusional states, psychosis, delirium, memory loss, hallucinations, movement disorders, sensory or motor complaints, seizures, dyssomnias, ataxias, nausea, vomiting, inappropriate antidiuresis, coma, dysautonomias, or hypoventilation in spinal fluid specimens

Diagnose Zollinger-Ellison (Z-E) syndrome; diagnose gastrinoma. Gastrin >1000 pg/mL with gastric acid hypersecretion (basal acid secretion >15 mmol/hour in a patient with peptic ulcer who has not had surgery) establishes unequivocally the diagnosis of the Zollinger-Ellison syndrome.4 Antral G-cell hyperplasia may relate to high gastrin lev...

This test is for determination of HCV genotype in patients with known HCV infection.

Monitoring serum concentrations of topiramate Assessing compliance Assessing potential toxicity

Therapeutic Drug Management       Includes Clozapine and Norclozapine

This test is intended for the in vitro qualitative detection of cytomegalovirus (CMV) DNA from urine . Results of this assay should be used in conjunction with the results of other clinical findings as an aid in the diagnosis of congenital CMV infection.

Order PDM # 5300520

FNA kit should be used. If FNA kit is not available, submit the entire specimen in ThinPrep CytoLyt solution (Blue Cap). For thyroids: If requesting reflex to molelcular tests, refer to the manufacturer instructions to see if specific proprietary collection media or additional requistions are needed. If applicable, the molecular request and re...

AVISE® HCQ is an advanced drug monitoring test that provides accurate measurement of hydroxychloroquine (HCQ)  levels in whole blood to help physicians assess their patients' exposure to hydroxychloroquine therapy.

       ** THIS IS A LAB ODERABLE ONLY **\ Lyme disease is transmitted by a tick vector carrying Borrelia burgdorferi. Immunoblot testing qualitatively examines, with high specificity, antibodies in a patient's specimen. Immunoblot testing is appropriate for confirming a detected EIA or IFA test result.

Serotonin measurement is used in conjunction with urinary 5-hydroxyindoleacetic acid (5-HIAA) and/or serum chromogranin A in the diagnosis of carcinoid syndrome.

Evaluate hyperviscosity syndrome associated with monoclonal gammopathy states (myeloma, macroglobulinemia of Waldenström, and other dysproteinemias), including occasional cases of rheumatoid arthritis, SLE, systemic lupus erythematosus, hyperfibrinogenemia
 

Investigation of suspected alternative pathway complement deficiency, atypical hemolytic uremic syndrome, C3 glomerulonephritis, dense-deposit disease

Diagnosis and monitoring of inherited aminoacidurias, organic acidurias, and urea cycle defects. May be used as a follow-up confirmatory test to some abnormal newborn screen results.
Limitations

Identifying individuals who are at increased risk of adverse drug reactions with drugs that are metabolized by UGT1A1; especially irinotecan but also atazanavir, nilotinib, pazopanib, and belinostat Identifying individuals with Gilbert syndrome due to the presence of homozygous UGT1A1*6 (c.211G>A, based on NM_000463.2) allele, TA7, homozygous ...

Assessing T-cell function in patients on immunosuppressive therapy, including solid-organ transplant patients Evaluating patients suspected of having impairment in cellular immunity Evaluation of T-cell function in patients with primary immunodeficiencies, either cellular (DiGeorge syndrome, T-negative severe combined immunodeficiency: SCID, et...

The presence of MOG antibodies in AQP4 antibody negative individuals can help differentiate between multiple sclerosis (MS) and non-MS demyelinating diseases and aid in clinical management decisions.

Useful in the differential diagnosis of acute myocardial infarction, megaloblastic anemia (folate deficiency, pernicious anemia), hemolytic anemia, and very occasionally renal infarct. These entities are characterized by LD1 increases, often with LD1:LD2 inversion.

Quantitative measurement of ACE in CSF. Angiotensin Converting Enzyme (ACE) is used in the assessment of neurosarcoidosis. The major sources of ACE are macrophages and epithelial cells. Patients with sarcoidosis display elevated levels of ACE.
 
Results of this test are labeled for research purposes only by the assay's manufacturer. The ...

The test detects functional autoantibodies to the Fc-epsilon receptor (high affinity IgE receptor) or to IgE and is useful in the evaluation of chronic urticaria.

Herpes Simplex Virus 1 and 2 (IgG), with Reflex to HSV-2 Inhibition - Herpes Simplex Virus (HSV) is responsible for several clinically significant human viral diseases, with severity ranging from inapparent to fatal. Clinical manifestations include genital tract infections, neonatal herpes, meningoencephalitis, keratoconjunctivitis, and gingivos...

Confirming the presence of a myopathy associated with any 1 of the following disorders
-Hereditary myoglobinuria
-Phosphorylase deficiency
-Sporadic myoglobinuria
-Exertional myoglobinuria in untrained individuals
-Crush syndrome
-Myocardial infarction
-Myoglobinuria of progressive muscle disease
-Heat injury
...

Differential diagnosis of myositis in patients with or without statin exposure.

Monitor therapeutic levels; evaluate toxicity

Evaluation of catecholamine-secreting tumors of the adrenal medulla (pheochromocytomas) and extra-adrenal sympathetic and parasympathetic paragangliomas.

The insulin-like growth factor (IGF) system plays a critical role in the growth and differentiation of normal and malignant cells.

Assess the function of the antral follicles the dominant follicle/corpus luteum of the ovaries in women
Limitations
Results from this ultrasensitive inhibin A test are not interchangeable with values obtained using the inhibin A test that is available as part of LabCorp's prenatal screening profiles.

The analysis of carnitines is indicated in patients who exhibit the following: failure to thrive, hypotonia, chronic muscle weakness, cardiomyopathy, intermittent episodes of weakness and encephalopathy, renal Fanconi's syndrome, hypoglycemic episodes, metabolic acidosis, or hypoketotic dicarboxylic acidurias.

For the detection of CMV in Saliva.

Since valproic acid is highly bound, drugs that compete for protein binding sites can increase the amount of free valproic acid (biologically active protein); these include dicumarol, high dose salicylates, and phenylbutazone. If toxicity is suspected, a free valproic acid level should be obtained.  

Alpha Thalassemia is a common hereditary trait and disease among individuals of Asian heritage.  Disease ranges in severity from mild abnormalities of erythrocytic indices to severe anemia.

Reverse triiodothyronine (rT3) is an isomer of triiodothyronine (T3) with no demonstrated biological activity.1,2 The majority of rT3 is produced through peripheral enzymatic monodeiodination of T4 at the 5 position of the inner ring of the iodothyronine nucleus of thyroxine (T4). A lesser amount of rT3 is secreted directly by the thyroid gland....

Serum concentrations of vedolizumab (VDZ) may vary among equally dosed patients which can ultimately affect patient outcomes. Some patients may develop immunogenicity to VDZ by producing antibodies to vedolizumab (ATV) and the presence of persistent anti-vedolizumab antibody has been observed to substantially reduce serum concentrations of vedol...

The ROMA™ (Risk of Ovarian Malignancy Algorithm) calculation combines the results of the Roche Elecsys HE4 assay, Elecsys CA 125 II assay and menopausal status into a numerical score (Roche). The ROMA value is intended to aid in assessing whether a premenopausal or postmenopausal woman who presents with an ovarian adnexal mass is at high or low ...

This test may be useful for diabetic patients treated with insulin analogs, as shown in the table below. Every patient's antibodies are different, and the specificity and avidity of the antibodies may affect the test.

Monitor exposure to mercury  

Diagnose the presence of a pheochromocytoma, neuroblastoma, and ganglioneuroblastoma

Lysosomal acid lipase deficiency (LAL-D) is a lipid storage disorder with two clinically distinct phenotypes, Wolman disease (WD) and cholesteryl ester storage disease (CESD). The LAL-D test is used to evaluate patients with a clinical presentation suggestive of lysosomal acid lipase deficiency and support a diagnosis of disease.

DNA-based determination of the two common alleles underlying α1-antitrypsin deficiency associated with chronic obstructive pulmonary disease (COPD) and childhood-onset liver disease. Prenatal testing is available.
Limitations  Tests for the two most common mutations, S and Z. Rare alleles, null or otherwise, are not detected by this ass...

Chronic urticaria is a common skin disorder affecting 1 to 6% of the general population. It is characterized by repeated occurrence of short-lived cutaneous wheals accompanied by redness and itching. Autoimmune urticaria is defined by the presence of a functional IgG antibody to high-affinity IgE receptor (Fc epsilon RI alpha) or to IgE. These a...

This assay uses LC/MS-MS to quantify the free acid, glycine-conjugate and taurine-conjugate forms of cholic acid, chenodeoxycholic acid, deoxycholic acid, and ursodeoxycholic acid. Bile acids may be measured to investigate obstructive cholestasis in pregnancy. In addition, bile acids are required for cholesterol absorption, fat-soluble vitamin ...

Primarily for research and to support attempts to understand the pathogenesis of immune, infectious, allergic, or inflammatory disorders.

The determination of MBL concentrations in serum may be useful for the elucidation of suspected immune defects and as a prognostic indicator alerting to the need for heightened therapeutic or prophylactic measures in immunosuppressed patients, including patients receiving cancer chemotherapy and patients with cystic fibrosis, SLE, or rheumatoid ...

Preferred test for detection of Pneumocystis

As an aid in the diagnosis of certain autoimmune thrombotic disorders, such as antiphospholipid syndrome (aPS). Antibodies to PS/PT  correlate with the presence of lupus anticoagulants (LA) and this test may be useful in cases with difficult LA test interpretation. This assay may also assist in the determination of risk for thrombosis as we...

Combines serologic, genetic, and inflammation markers to help identify active celiac disease and stratify relative risk. . Test Code 6360

Detecting antibodies to Coccidioides immitis/posadasii This assay should not be used for monitoring response to therapy.

Coenzyme Q10 (CoQ10) is also referred to as ubiquinone because it can be found in almost all eukaryotic cells. CoQ10 is also a powerful lipid-soluble antioxidant protecting cell membranes and lipoproteins. CoQ10 is present in the plasma in both the reduced (ubiquinol) and oxidized (ubiquinone) forms.

Myelin Oligodendrocyte Glycoprotein (MOG) Antibody with Reflex to Titer, CSF - Neuromyelitis optica (NMO) is an inflammatory disorder predominantly affecting the optic nerves and spinal cord. Limited forms of disease including isolated optic neuritis, brainstem encephalitis and longitudinal extensive transverse myelitis (LETM) or acute dissemina...

Microorganisms play a major role in both acute and chronic eye conditions. To successfully recover offending organisms, it is necessary to know the clinical syndrome and site of infection. Not evaluated for Chlamydia. For Chlamydia Eye cultures- TEST ID: MCTGC on an Aptima collection device- Chlamydia trachomatis and Neisseria gonorrhoeae, Mi...

Testing for Bethesda Units is performed to quantify the degree of inhibition for an individual factor when specific factor inhibitor has been diagnosed, and to follow the patient with a factor inhibitor during therapy(most oftern fact VIII inhibitors).
Please indicate the specific factor inhibitor if factor assays have already been tested in ...

Provides evidence of an existing or past streptococcal infection

*** Test Has been Discontinued at All Reference Labs*** It is not available

Aid in diagnosing Coxsackie virus infection. Coxsackie B viruses cause a wide variety of illnesses, including  pleurodynia (Bornholm disease), meningitis, rash, pulmonary infection, and a generalized systemic infection.

Predict risk of dose-related toxicity to 5-FU therapy

Quantitative JCV DNA PCR can be used to detect JCV in CSF in the setting of CNS disease, and blood and urine in the setting of renal dysfunction. Quantitative DNA PCR can be used to track the course of infection as well as monitor response to treatment.
 

Aid in the diagnosis of non-acute (chronic phase) Chagas disease (T. cruzi).

This test provides a calculated likelihood (i.e., risk estimate) of identifying high-grade prostate cancer in men if a prostate biopsy were to be performed. It is intended to be utilized in men without a previous diagnosis of prostate cancer to determine the need for a prostate biopsy by their urologist. https://riskcalc.org/PBCG/ 

Confirm and quantify the presence of hepatitis E virus.

Distinguish between high T4 levels due to hyperthyroidism and due to increased binding by TBG in euthyroid individuals who have normal levels of free hormones; document cases of hereditary deficiency or increase of TBG; work-up of thyroid disease.

Measurement of vitamin B5 level

This assay uses indirect immunofluorescence to determine IgG titers to Coxsackie A serotypes A7, A9, A16, and A24. Recent infections of Coxsackie viruses are characterized by elevated titers of IgG and IgM.

The preferred method for detecting B miyamotoi is real-time polymerase chain reaction.

The advanced lipid profile provides a more comprehensive assessment of dyslipidemia and cardiovascular risk than standard  lipid panel measurements

This test is used to evaluate glucose 6-phosphate dehydrogenase (G6PD) deficiency. G6PD deficiency, an X-linked disorder, is the most common enzymatic disorder of red blood cells in humans, affecting more than 400 million people worldwide

Aiding in diagnosing adenovirus infections

Recommended for clinical situations in which increased sensitivity of E2 levels is appropriate, including postmenopausal women, men, and children and adolescents

NMR LDL-P is a management tool used in appropriate high-risk patients (type 2 diabetes mellitus, metabolic syndrome, CVD risk equivalent, statin-treated patients) to adjudicate response to treatment and guide adjustment in therapy. It is used in conjunction with other lipid measurements and clinical evaluation to aid in the management of lipopro...

Evaluating patients suspected of having systemic mastocytosis Identification of aspirin sensitivity in patient respiratory diagnoses

Hepatitis D Virus (HDV) infection occurs in association with HBV infection. A positive result for HDV IgM indicates recent HDV infection.

Monitoring tobacco use
 
Monitoring patients on nicotine-replacement therapy for concurrent use of tobacco products

Therapeutic Drug monitoring

Detection of antibodies to JCV in serum or plasma is a reliable indicator of exposure to JCV. The analytical performance characteristics were determined for multiple sclerosis patients.

As part of the diagnostic workup of suspected insulinoma As part of the diagnostic workup of patients with suspected prohormone convertase1/3 deficiency As part of the diagnostic workup of patients with suspected proinsulin variations

Evaluation of patients with suspected human monocytic ehrlichiosis, human granulocytic anaplasmosis, babesiosis, or Borrelia miyamotoi infection Evaluation of patients with a history of, or suspected, tick exposure who are presenting with fever, myalgia, headache, nausea, and other nonspecific symptoms Includes: Babesia species, PCR Ehrlichia/...

Evaluate the classical complement pathway
 
Levels are depressed in various immunodeficiency states including x-linked hypogammaglobulinemia and severe combined immunodeficiency (10% to 25% of normal levels). Genetic deficiencies of C1q have been described.

Aiding in the diagnosis of Histoplasma meningitis

Screen for the presence of circulating antibodies to platelets (not bound to the platelet surface), that may be associated with the destruction of platelets.
 

Aid in the diagnosis of rheumatoid arthritis (RA) Limitations Results of this panel should be used in conjunction with clinical findings and other laboratory tests.

Infection with Human Immunodeficiency Virus type 2 (HIV-2) is currently diagnosed by the presence of antibodies to HIV-2, the detection of specific HIV-2 antigens or the ability to culture HIV-2 from blood, fluid or tissue of infected persons. presentation and additional clinical tests.

Esterase inhibitor is decreased in hereditary angioneurotic edema. Functional level will be decreased when concentration of inhibitor is decreased or inhibitor is nonfunctional.

This test is intended to be used as an aid in the diagnosis of infections caused by varicella zoster virus (VZV).    Any lesion or tissue order on VTM media order HSV12 VZV PCR

Screening for and confirming the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) Monitoring patients with PNH

The assay is used as an aid in monitoring recurrence or progressive disease in patients with epithelial ovarian cancer. Serial testing for patient HE4 assay values should be used in conjunction with other clinical findings used for monitoring ovarian cancer.

Urine organic acid testing is useful in the diagnosis and monitoring of patients with inborn errors of organic acid metabolism, inborn errors of amino acid metabolism, urea cycle defects, and defects of the mitochondrial respiratory chain.

Clinical information, together with the physician’s assessment of cytology history, other risk factors, and professional guidelines, may be used to guide patient management.

Identification of the Ixodes tick species will result in reflex to Real-Time PCR for detection of Borrelia species in the tick. T

This test determines titers of neutralizing antibody against poliovirus 1 and 3, and is intended to be used in assessing immune status.

Study patients for IgD myeloma and hyperimmunoglobulinemia D syndrome (HIDS)

Allopurinol associated SCAR (severe cutaneous adverse drug reaction) including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) has been shown to be associated with the human leukocyte antigen (HLA) B*58:01 of the major histocompatibility complex (MHC). The MHC family of genes codes for a highly variable set of cell surface...

Monitoring adequacy of serum concentration during amikacin therapy

Use to evaluate malabsorption due to disaccharidase deficiency

Accurate measurement of serum thyroglobulin (Tg) in patients with known or suspected antithyroglobulin autoantibodies (TgAb) or heterophile antibodies (HAb) Reflex testing of samples with previously unknown TgAb status that prove TgAb positive during immunoassay testing Assisting in the differential diagnosis of early phase silent thyroi...

Identify drug resitance mutations in HIV-1 patients failing antiretroviral regimens containing RT, PR or Integrase inhibitors. Identify transmitted drug resistance mutations in the RT, PR or integrase genes in treatment-naive patients prior to initiation of antiretroviral therapy.

This assay measures the red-cell concentration of 6-MMP (formed from 6-MP by thiopurine methyltransferase) and also measures the concentration of the resulting 6-TG after removal of the mono-, di-, or tri-phosphates from the various 6-thioguanine nucleotides.

Laboratory diagnosis of mumps virus infection

Evaluate magnesium deficiency

This assay is used for the detection of nicotine and cotinine in serum and plasma to determine the tobacco exposure status of the individual. Nicotine has a short half-life of approximately forty minutes; its presence may indicate recent tobacco exposure. Cotinine, the major nicotine metabolite, has a half-life of 24 hours and is detectable for ...

Detect antibodies for P/Q type and N-type voltage-gated calcium channels. Aid in the evaluation of muscle weakness in the context neuromuscular junction disorder with or without cancer, or the diagnosis of paraneoplastic neurological syndromes. .

Sunrise Clinical Manager (SCM) order: Finronectin, Fetal
Allscripts (AEHR) Orerable: Fetal Fibronectin

Aid in the diagnosis of viral diseases (eg, conjunctivitis, congenital viral infections, keratitis, chickenpox, shingles, viral pneumonia, and diseases characterized by skin vesicles and rashes)

Dectection of anti-sulfatide antibodies.

This assay differentiates between previous exposure/infection and current infection. Serological testing is not recommended for diagnosis. Per current recommendations, culture of lower respiratory secretions and/or the Legionella urinary test should be used for diagnosis of infection with Legionella..

This test is used to determine the presence of BK and JC virus DNA in patient's specimens. han the host's reaction to the virus.

Monitoring trough levels of voriconazole is suggested in patients with impaired liver function, patients with pharmacogenomics polymorphisms associated with lower metabolism of voriconazole (e.g. genotypes CYP2C19*2 and CYP2C19*3), and in patients taking other medications that affect CYP2C19 activity.

AVISE Anti-CarP is a specialized lab test to help identify rheumatoid arthritis (RA) patients with an increased risk  for erosive joint damage. Classifying RA early may give the best chance of gaining and maintaining control over  the permanent and debilitating effects from RA.

Molecular confirmation of a clinical diagnosis in symptomatic patients Risk assessment of asymptomatic family members of a proband with cardiomyopathy and/or arrhythmia Differentiation of hereditary cardiomyopathy and/or arrhythmia from acquired (non-genetic) cardiomyopathy and/or arrhythmia Recurrence risk calculation

Discrimination between recent (primary) and past cytomegalovirus (CMV) infection can be an important tool in the clinical management of transplant recipients and pregnant women. 

Monitor exposure to copper

May aid in the diagnosis of toxocariasis caused by infection with Toxocara canis.

Molecular confirmation of a clinical diagnosis To assist with decisions about treatment and management of individuals with neuropathy Testing of at-risk relatives for specific known mutation(s) previously identified in an affected family member    Prenatal diagnosis for known familial mutation(s) in at-risk pregnancies

Mayo code FMMPP The MyoMarker Panel 3 Plus can be used to assist in the diagnosis of dermatomyositis, polymyositis and the anti-synthetase syndrome. Furthermore, it allows characterization of various subsets of these disorders and offers prognostic information.

DCP is intended for use as an aid in the risk assessment of patients with chronic liver disease for progression to hepatocellular carcinoma in conjunction with other laboratory findings, imaging studies, and clinical assessment.1
Limitations
It is recommended that this assay be used in conjunction with imaging studies for clinical diagno...

Aiding in the diagnosis of active histoplasmosis using serum specimens

Used in the diagnosis and monitoring of inherited disorders of fatty acid oxidation and organic acidurias. May be used as a follow-up test to some abnormal newborn screen results.

This test is intended for use as an aid in the diagnosis of HIV-1 infection, including acute or primary infection. Presence of HIV-1 RNA in the plasma of patients without antibodies to HIV-1 is indicative of acute or primary HIV-1 infection. This assay may also be used as an supplemental test for specimens that repeat negative results with appro...

Diagnosis of acute promyelocytic leukemia (APL) Detection of residual or recurrent APL Monitoring the level of promyelocytic leukemia/retinoic acid receptor alpha (PML/RARA) in APL patients

SensoriMotor Neuropathy Profile with Recombx®-Complete - Anti-MAG, anti-SGPG, anti-GM1, anti-GD1a, anti-GD1b, anti-asialo GM1, anti-sulfatide, anti-Hu, and IgM GALOP antibodies are found in patients with a peripheral neuropathy and mixed sensory and motor symptoms. This semi-quantitative assay may be useful in monitoring therapeutic responses in...

For the assessment of liver status following a diagnosis of HCV as well as post-treatment assessment of liver status six months after completion of antiviral therapy. For use in patients who are at risk of complications from a liver biopsy.

Detect the presence of prescribed, over-the-counter, and illicit drugs for the purpose of medical drug monitoring.

Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmun...

  **  Use only Quest 24-hour Urine Collection Kits specific for renal stone formation diagnosis.  ** This profile is for stone formers with a positive urine culture indicating urinary tract infection (UTI), also for recurrent stone formers or when  attending physician deems it medically necessary for the patient to have...

An aid in the detection and monitoring of neuroendocrine tumors (NETs), particularly those associatedwith small-cell lung cancer (SCLC)

An aid in the diagnosis of dengue virus infection
Detection of antibodies to dengue virus is suggestive of recent exposure and/or infection with dengue virus.
 
This test should be used for diagnostic purposes only.

The Fungitell ß-D Glucan assay is indicated for the presumptive diagnosis of invasive fungal disease through detection of elevated levels of (1,3)- ß-D-glucan in serum.

**  MUST DRAW CONTROL SAMPLE UNRELATED PATIENT **           Specimens accepted less than 24hours post collection, Monday -Thursday noon Diagnosis of chronic granulomatous disease (CGD), X-linked and autosomal recessive forms, complete myeloperoxidase (MPO) deficiency; monitoring chimerism and nicotinamide a...

Establish evidence of infection/exposure to Bordetella pertussis, the causative agent of whooping cough

Tumor marker

Only available for Northwell Hospital patients

As an adjunct in the diagnosis of trichinosis

Monitor immune complex disease (ie, lupus, glomerulonephritis, serum hepatitis, arthritis, vasculitis); monitor progress of some malignancies
 
Circulating immune complexes can be demonstrated in rheumatic, infectious, and neoplastic diseases, as well as most immunologically mediated illnesses (inflammatory bowel disease, thrombotic thro...

This test provides qualitative detection of human IgG and IgM antibodies against Brucella abortus in human serum. This test can be used to aid in the diagnosis of brucellosis in conjuction with other laboratory and clinical findings.

Insertion of a catheter into a blood vessel compromises the skin’s ability to exclude organisms that colonize the surface of the skin. Devices such as heparin locks, hemodialysis shunts, TPN catheters, and arterial catheter lines expose patients to increased risk of infections. If catheter associated septicemia is suspected, it is important to d...

5-HIAA is the end product of serotonin (5-hydroxytryptophan) and tyrptophan metabolism. Patients with carcinoid tumors of the midgut, e.g., ileum, produce high concentrations of 5-HIAA. Patients with carcinoid tumors of the foregut and hindgut may produce little or no 5-HIAA or do so intermittently..

Aids in the diagnosis of leptospirosis This is test is intended to be used as an aid for the diagnosis of acute or recent leptospirosis due to infection with Leptospira species. This is a qualitative immunodot test for detection of IgM-class antibodies to Leptospira species. A negative result by this assay does not exclude the possibility o...

This assay is intended to be used as an aid to the diagnosis of Bordetella pertussis (whooping cough) and Bordetella parapertussis (whooping cough-like syndrome).

Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular abnormalities, and cutaneous and visceral fibrosis.

For Pediatric patients only

Comprehensive thyroglobulin can be used to monitor recurrence of thyroid cancer. All specimens are tested for the presence of antithyroglobulin autoantibodies (anti-Tg). Specimens negative for the presence of anti-Tg are reflexed to thyroglobulin testing by ICMA, and specimens positive for the presence of anti-Tg are reflexed to thyroglobulin te...

Differentiate between Chlamydophila species (C. psittaci, C. pneumoniae). Differentiate early IgM response to infection from persistent low-level titer.  

 
Detect the presence of illicit drugs, including ethanol
 

Used as an aid in the diagnosis of systemic lupus erythematosus (SLE) in conjunction with other laboratory and clinical findings.

Simultaneously measures ustekinumab (UST) and antibodies to ustekinumab (UST) levels in serum at any time during therapy.
 
Quantify whether inflammatory bowel disease patients have antibodies and/or sufficient drug concentrations Measure antibodies in the presence of drugs (i.e., drug tolerant assay) Overcome many of the limitations of...

Assess patients with hereditary deficiency of this component or acquired decrease in its level which may be seen due to hypercatabolism in hereditary angioneurotic edema, or consumption or loss as in vasculitides, glomerulonephritides, immune complex diseases. C2 deficiency is the most common complement deficiency (1 in 10,000) and is associated...

Ethosuximide is an anticonvulsant used to treat seizures. Ethosuximide levels are monitored to assure adequate therapeutic levels are achieved and to avoid toxicity.

Paraneoplastic Syndrome involves non-metastatic systemic effects that accompany malignant disease. Antineuronal Nuclear Antibody (Anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Anti-Hu is associated with subacute syndrome of encephalomyeloradiculopathy, sensory neuropathy, and autoimmune neuropathy, predominantly ...

This test is being discontinued Please order ADALIMUMAB PROMETHEUS Anser ADA allows for the detection of both drug-free and drug-bound antidrug antibodies in a patient's serum.

Ordering Recommendation Not recommended for diagnosing congenital infections in newborns; tests should be selected individually to target the most likely infectious agents.

Monitoring adequacy of serum concentration during amikacin therapy

A positive urine alcohol is only indicative of recent use and cannot be used to determine impairment. This test should be restricted to monitoring patients in drug treatment programs where any alcohol use is prohibited.

This assay uses the microsomal fraction of adult S. mansoni worms (MAMA) as antigen, and is thus highly specific (99%) and sensitive (96%) for detection of infection caused by S. mansoni.

Monitor patients for prior and ongoing exposure to aluminum

Monitor industrial exposure. This test is not intended to monitor chromium levels in diabetic patients or in patients with suspected chromium deficiencies.

Mayo Test code FGQ1B

Monitor industrial exposure to cobalt
 

Aid in the diagnosis of urine concentration disorders, especially diabetes insipidus, syndrome of inappropriate ADH (SIADH), psychogenic water intoxication, and syndrome of ectopic ADH production.
 
ADH, produced in the supraoptic and paraventricular locations of the hypothalamus, acts on the collecting tubules of the kidney to cause inc...

5′ nucleotidase is used to investigate the origin of increased serum alkaline phosphatase. It is a liver-related enzyme used to work up cholestatic/biliary obstruction. It parallels the increases of alkaline phosphatase and leucine aminopeptidase in hepatobiliary diseases, but is not usually elevated in skeletal disorders such as Paget disease o...

The anti-PM/Scl-100 antibody is associated with younger age, calcinosis and has lower rates of gastrointestinal symptoms, ILD and pulmonary hypertension. There is also evidence of a possibly better survival compared to the presence of either anti-PM/Scl-75 or anti-Scl-70 antibodies.

Values above 10 mg/24 hours occur in carcinoid syndrome. Slight elevations also occur in nontropical sprue and after reserpine administration.

Low Factor XIII levels, i.e., <15%, may cause a bleeding disorder and levels <2% have been associated with spontaneous introcranial hemorrhage

The test can detect over 176 health conditions that can be passed unknowingly from parent to child plus Fragile X.

Preferred test to evaluate if etiology of hypoglycemia is sulfonylurea ingestion. Includes: Chlorpropamide, Glimepiride, Glipizide, Glyburide, Nateglinide, Pioglitazone, Repaglinide, Rosiglitazone, Tolazamide, Tolbutamide

Measure histamine that was released in vivo prior to collection of the specimen; evaluate possible systemic mastocytosisLimitationsResults for this test are for research purposes only by the assay's manufacturer. The performance characteristics of this product have not been established. Results should not be used as a diagnostic procedure withou...

Used for the diagnosis and prognosis of histoplasma infections.

Voltage-Gated Potassium Channel (VGKC) antibodies are associated with neuromuscular weakness as found in neuromyotonia (also known as Issacs syndrome) and Morvan syndrome. VGKC antibodies are also associated with paraneoplastic neurological syndromes and limbic encephalitis; however, VGKC antibody-associated limbic encephalitis may be associated...

Assessing T-cell function in patients on immunosuppressive therapy, including solid-organ transplant patients Evaluating patients suspected of having impairment in cellular immunity Evaluation of T-cell function in patients with primary immunodeficiencies, either cellular (DiGeorge syndrome, T-negative severe combined immunodeficiency: SCID, e...

Detects anti-LRP4 (low density lipoprotein receptor-related protein 4) in the sera of patients with Myasthenia Gravis (MG).

Initial screening test in the diagnosis of bullous pemphigoid and its variants Complementing the standard serum test of indirect immunofluorescence utilizing primate esophagus substrate and  primate salt-split skin substrate (CIFS / Cutaneous Immunofluorescence Antibodies [IgG], Serum)

Myositis-specific antibody

Monitoring adequacy of serum concentration during tobramycin therapy
 

This test is used to measure the level of vasoactive intestinal polypeptide (VIP) in plasma.

Assessment of tumor progression and prognosis
Limitations
Results of this test are labeled for research purposes only by the assay's manufacturer.

This test is used for measurement of Intact N-Terminal Propeptide of Type 1 Procollagen (PINP) levels in serum.

 1) To identify disease-causing mutations in individuals affected with beta-thalassemia. 2) To identify carriers in high-risk ethnic group or people with positive family history. 3) Prenatal diagnosis of beta-thalassemia.

Not recommended for evaluation of general hearing loss. The presence of HSP70 IgG antibodies may be useful in predicting corticosteroid responsiveness in a subset of patients with autoimmune inner ear disease (AIED) characterized by idiopathic rapidly progressive sensorineural hearing loss (SNHL). HSP70 IgG antibodies are also associated with a ...

Diagnosing infections due to Mycoplasma (Mycoplasmoides) pneumoniae Assessing macrolide susceptibility

Molecular confirmation of a clinical diagnosis Testing of patients suspected of having a mitochondrial disorder GeneDx code 615

The spectrum of illness due to Legionella spp. ranges from a mild, self-limited illness (Pontiac fever) to atypical pneumonia (Legionnaire’s disease), to serious disseminated disease. It is estimated to cause 2 to 15% of all sporadic community-acquired pneumonias requiring hospitalization. The bacterium is generally transmitted by inhalation of ...

Detection and quantitation of BK Virus (BKV) in urine stabilized in cobas® PCR Media can be used as an aid in the diagnosis and management of BK virus infections.

Clinically, the measurement ofcirculating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (pheochromocytomas, neuroblastomas, and gangliomas) and with the evaluation of orthostatic hypotension.

Neonates, who have been exposed to HSV, can develop disseminated infection and encephalitis; molecular amplification testing is useful in the diagnosis of HSV infection. Skin/mucosa, blood, and CSF molecular tests have been validated and are available at Northwell Health Laboratories.

This α1-antitrypsin ELISA test is intended for the quantitative determination of α1-antitrypsin in stool samples.

Confirmation of clinical diagnosis in symptomatic patients Risk assessment of asymptomatic family members of a proband with TAAD Differentiation between familial TAAD, Marfan syndrome, Loeys-Dietz syndrome and phenotypically related disorders.

The diagnosis of lyme disease is most often made by clinical examination combined with evidence of tick bite or exposure in endemic areas. Amplification of Borrelia genomic DNA from blood, fluids or tissues can support the diagnosis Order TICKID which will identify the insect and reflex to the LymeTick if required

Detection of Chikungunya virus antibodies is a reliable indicator of Chikungunya virus infection. IgM detection suggests infection within the previous 3 months.  
This test is for Outreach only

Confirming the autoimmune basis of a defect in neuromuscular transmission (eg, myasthenia gravis [MG], Lambert-Eaton myasthenic syndrome [LEMS]) Distinguishing LEMS from autoimmune forms of MG Providing a quantitative autoantibody baseline for future comparisons in monitoring a patient's clinical course and response to immunomodulatory treatment...

Screening for mast cell activation disorders including systemic mastocytosis using random urine specimens 2,3-Dinor-11beta-prostaglandin F2 alpha (2,3 BPG) is the most abundant metabolic product of prostaglandins released by activated mast cells. Systemic mastocytosis (SM) is a disease in which clonally derived mast cells accumulate in peripher...

Therapeutic drug management

Isoagglutinins are antibodies produced by an individual that cause agglutination of RBCs in other individuals. People possess isoagglutinins directed toward the A or B antigen absent from their own RBCs. For example, type B or O individuals will usually possess anti-A. The anti-A is formed in response to exposure to A-like antigenic structures f...

Detect fetal exposure to controlled substances Test Includes Amphetamines; Cocaine metabolite; Phencyclidine (PCP); Cannabinoids (THC metabolite); Opiates

Predicting potential for toxicity to thiopurine drugs

Aids in the diagnosis of paraneoplastic neurological autoimmune disorders related to carcinoma of lung, breast, ovary, thymoma, or Hodgkin lymphoma in spinal fluid specimens

Determining the presence of cerebrospinal fluid in body fluids The diagnosis of cerebrospinal fluid (CSF) rhinorrhea or otorrhea (leakage of CSF into the nose or ear canal, usually as a result of head trauma, tumor, congenital malformation, or surgery) is often difficult to confirm. Traditional chemical analyses (eg, glucose, protein, specific ...

This test is intended only for screening for Methicillin Resistant Staphylococcus aureus (MRSA) colonization and is not intended to diagnose MRSA infection or to guide or monitor treatment for infections. It is for infection control surveillance purposes only.

Assess risk of ovarian cancer in women who present with an adnexal mass.

Mayo code: NMOFC Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD) Diagnosis of autoimmune AQP4 channelopathy Distinguishing NMOSD from multiple sclerosis early in the course of disease When the results of this assay require further evaluation, NMOTC / Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (F...

Screening for exposure to Coxiella burnetii, the causative agent of Q fever This test should not be used as a screening procedure for the general population. If the Q fever serology result is reactive, then Q fever antibody confirmation by indirect immunofluorescence will be performed at an additional charge.

The culture uses a selective and differential chromogenic medium which is intended for the qualitative detection from stool specimens of: Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli, Klebsiella pneumoniae and Klebsiella oxytoca.

This test is intended to be used as an aid in the diagnosis of infections caused by Bartonella henselae or Bartonella quintana..

Behcet Disease (BD) is a rare, chronic, multisystem disease caused by vasculitis of blood vessels throughout the body. The disease course is marked by recurrent ulcers of the oral and genital regions, often with severe ocular inflammation that may lead to visual impairment or blindness. This disease is found most often in individuals that carry ...

Monitoring effectiveness of therapy in patients with hyperphenylalaninemia This test is not sufficient for follow-up for abnormal newborn screening results or for establishing a diagnosis of a specific cause of hyperphenylalaninemia.

Measurement of 21-hydroxylase autoantibodies aids in diagnosis and management of patients with adrenal insufficiency.

Amiodarone is a class III antiarrhythmic agent approved for the treatment of life-threatening ventricular tachyarrhythmias. Because of potential toxicity the serum level of this drug should be monitored.

Plasminogen levels can be decreased in disseminated intravascular coagulation (DIC), hepatitis, leukemia, and with thrombolytic therapy.
 
 

It can identify patients with Filarial infections caused by D. immitis, W. bancrofti, B. malayi and O. volvulus. Chronic infections manifesting as elephantiasis may not result in a significant IgG4 antibody response and cannot be ruled out by this test.

Evaluate hemolytic anemia, especially intravascular hemolysis. Plasma hemoglobin is increased with intravascular hemolysis, ABO incompatible transfusion, traumatic hemolysis, falciparum malaria, burns, and march hemoglobinuria. Increase may occur in some cases of extravascular hemolysis, delayed transfusion reaction, slight increase in sickle ce...

Order test when Allegen is not listed

Preferred screening test for detection of arsenic, cadmium, mercury, and lead in random urine specimens If the total arsenic concentration is 10 mcg/L or greater, then speciation will be performed at an additional charge.

Establish the diagnosis of infection due to Blastomyces dermatitidis

Prognostic marker for patients with CLL. Hypermutated IgVH is a favorable prognostic indicator in CLL.

The work-up of individuals having febrile, nonhemolytic transfusion reactions The detection of individuals with autoimmune neutropenia

Detect use of ethanol

Monitor exposure to iodine; evaluate for iodine deficiency disorders (IDDs), excessive iodine intake, or iodine in the workplace.

Detect circulating immune complexes (CIC)

Peanut allergen reflex to Peanut Component Panel

Evaluating patients with possible peroxisomal disorders, single-enzyme defects of peroxisomal metabolism such as X-linked adrenoleukodystrophy  or peroxisomal biogenesis disorders (Zellweger syndrome spectrum) using serum specimens Aiding in the assessment of peroxisomal function This test analyzes very long-chain fatty acids (VLCFA) as wel...

This test is used to: 1. Identify HBV genotype (A-H) for epidemiology or prognostic purposes. 2. Detect hepatitis B virus (HBV) mutations associated with resistance to antiviral agents.

Analyzes a patient’s genetic profile for disease risk stratification. Test code 6260

Detect Legionella species

Some parasites can be found in extraintestinal areas and require examination of other specimen types other than stool. These specimens include, duodenal aspirate, aspirates from various anatomical sites, bronchoscopy specimens, sputum, urogenital specimens, urine etc.

Preferred screening test for patients suspected to have an autoimmune blistering disorder of the skin or mucous membranes (pemphigus) Aiding in the diagnosis of pemphigus

Evaluate exposure to methanol

Recommended for differential evaluation of neuromuscular junction diseases including myasthenia gravis (MG).

This test number is not intended for workplace testing and does not comply with state regulatory workplace testing programs. Ethylene glycol is a colorless, odorless, sweet tasting compound used commercially in antifreeze. It has been utilized in suicide attempts, as a substitute for ethanol and in accidental poisonings in both children and dom...

Pediatric testing for the evaluation of hypertension; diagnose and follow up neuroblastoma, ganglioneuroma, and ganglioneuroblastoma. Most neuroblastoma patients excrete excess HVA in 24-hour collections. If VMA and HVA are both used in work-up, up to 80% of all cases will be detected.

Available for Hospital ED only

  Monitor recent or acute exposure to arsenic  

Evaluate toxicity; monitor therapeutic levels

The presence of mitochondrial antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of  primary biliary cirrhosis (PBC).

1. To identify disease-causing mutations in individuals affected with alpha-Thalassemia. 2. To identify carriers in high risk ethnic groups or people with a positive family history. 3. Prenatal diagnosis of alpha-Thalassemia.

Purkinje Cell (Yo) antibody is found in approximately half of the patients with paraneoplastic cerebellar degeneration and is associated with ovarian, uterine, and small cell lung carcinomas and Hodgkin’s lymphoma

Diagnosis of C5 deficiency Investigation of a patient with an absent total complement (CH50) level

Detect resistance of HIV-1 to protease, reverse transcriptase, and integrase inhibitors. Limitations This procedure may not be successful when the HIV viral load is <500 copies/mL plasma. If there is insufficient virus to produce results,

Evaluate parotitis and pancreatic disease. Amylase is primarily produced in the pancreas and salivary glands. Isoenzymes may be used to determine the source of an  elevated amylase concentration. Measurement of pancreatic amylase activity is of value in diagnosing pancreatitis and other pancreatic disorders that result in the elevation ...

Chlamydophila pneumoniae Antibodies (IgG, IgA, IgM) - Chlamydophila pneumoniae is a common cause of infantile and community-acquired pneumonia.

Measurement of pancreatic polypeptide in serum.

It is an advanced diagnostic test specifically designed to aid in the differential diagnosis of ANCA-associated vasculitis(AAV).

Serotonin measurement is used in conjunction with urinary 5-hydroxyindoleacetic acid (5-HIAA) and/or serum chromogranin A in the diagnosis of carcinoid syndrome.

Glucagon measurement is useful primarily when considering a glucagon-secreting tumor of the pancreas. Glucagon is also used to diagnose glucagon deficiency in patients with hypoglycemia

Plasma and serum are required for this test. CRYOGLOB “Cryoglobulin, Serum” must be ordered with this test

Differential diagnosis of leukemia. Present in association with some cases of myelogenous leukemia and in most cases of monocytic leukemia.  

Monitoring trough levels of posaconazole is suggested in patients with suboptimal nutritional intake (and therefore requiring food and liquid nutritional supplementation), or in patients with gastrointestinal disease such as mucositis, diarrhea, vomiting or GVHD.

Zika Virus Real-time RT-PCR test is a real-time RT-PCR test intended for the qualitative detection of RNA from Zika virus in human plasma, serum or urine (collected alongside a patient matched serum or plasma specimen).

Cryptococcus neoformans is a yeast-like organism found commonly in pigeon bird droppings. Cryptococcus is associated with subacute and chronic meningitis, pulmonary, skin, bone, and other lesions, especially in patients who are immunocompromised.

Measure the quantity of PAI-1 in plasma, which may be useful in the determination of PAI-1 deficiency

Evaluate renal disease; monitor certain types of malignancies and AIDS  

Screening for mast cell activation disorders including systemic mastocytosis using 24-hour urine specimens 2,3-Dinor-11beta-prostaglandin F2 alpha (2,3 BPG) is elevated in the urine of patients with systemic mastocytosis (SM). This test should be used as a screening test for SM. When 2,3 BPG is used in combination with urinary leukotriene E4 ...

For therapeutic drug monitoring, specimens should be drawn as trough levels.

Stony Brook as discontinued Western Blot testing for Lyme due to reagent supply issue. Tests will be cancelled.

Anti-cN-1A autoantibodies in idiopathic inflammatory myopathy (IIM) patients appear to be disease-specific for sporadic Inclusion Body Myositis (sIBM) and are rarely detected in other autoimmune conditions. Anti-cN-1A autoantibodies have a moderate sensitivity, but their high specificity for sIBM may be helpful in the diagnosis of this infrequen...

Elevated levels of chitotriosidase activity reflect excess lipid storage and may be useful in monitoring the treatment of Gaucher disease.

Quantitative JCV DNA PCR can be used to detect JCV blood in the setting of renal dysfunction. Quantitative DNA PCR can be used to track the course of infection as well as monitor response to treatment.

Diagnosing congenital alpha-2 plasmin inhibitor deficiencies (rare) Providing a more complete assessment of disseminated intravascular coagulation, intravascular coagulation and fibrinolysis, or hyperfibrinolysis (primary fibrinolysis), when measured in conjunction with fibrinogen, fibrin D-dimer, fibrin degradation products, soluble fibrin mono...

Primidone is used principally in generalized tonic-clonic and complex and simple partial seizures; some clinicians believe that the drug has specific usefulness for complex partial seizures.

It is a screening test for the presence of Vancomycin resistant Enterococcus (VRE). This test is intended for infection control surveillance purposes only.

Confirmation of a clinical diagnosis To assist in determining the most appropriate therapy, as the response to specific therapeutic modalities depends on the diagnosis Recurrence risk Carrier testing in at-risk family members Prenatal diagnosis

This is a screening test for the presence of CRE (Carbapenemase-Producing Enterobacterales) organisms Klebsiella pneumoniae and E.coli from rectal swabs. This test is intended only as a surveillance culture for infection control purposes. CRE organisms pose challenge for infection control in health-care facilities and also for treatment of infe...

To be usedfor Inhouse Northwell Patients undergoing treatment.

Measurement of Natural Killer (NK) Cells is useful in the diagnosis of retinoblastomas, medulloblastomas, astrocytomas, and neuroblastomas.
Avoid transport just before or during weekends, which can result in preassay delay
Stability 72 hours only drawn Monday - Thursday only

Mayo Code FFMI2

Quantitative HHV-6 DNA PCR can be used for early detection of a primary infection, for tracking the course of infection, and for monitoring response to treatment. Quantitative HHV-6 DNA PCR does not differentiate HHV-6 viremia from patients with chromosomally integrated HHV-6, a relatively uncommon congenital occurrence that has not been conclus...

The meningococcal vaccine response is best evaluated by testing pre-vaccination and post-vaccination samples in parallel.

Screen measures 176 conditions associated with serious and prevalent inherited conditions

Lidocaine levels are monitored to assure adequate therapeutic levels are achieved and to avoid toxicity.

Study of adrenocortical-renin-angiotensin system; adrenal cortical function test; evaluate renal hypertension; diagnose Conn syndrome (primary aldosteronism); evaluate hypokalemia with hypertension

Detection of Mycoplasma genitalium in cases of suspected infection This test is not intended for use in medico-legal applications.

This test should be used for screening for bile acid malabsorption, a condition in which excess bile acids are found in the stool that is one cause of chronic diarrhea. This test should be used for screening for bile acid malabsorption, a condition in which excess bile acids are found in the stool that is one cause of chronic diarrhea.

Monitor exposure to nickel

c-KIT is a proto-oncogene that encodes a type III transmembrane tyrosine kinase. c-KIT and its ligand stem cell factor have a key role in survival, proliferation, differentiamyeloid leukemia (AML), and approximately 20% high-grade myelodysplastic syndrome (MDS) and MDS-derived AML. c-KIT mutation in AML confers increased risk of relapse and...

Follow-up testing to identify variants in individuals with a clinical diagnosis of cystic fibrosis (CF) Identifying genetic variants in individuals with atypical presentations of CF (eg, congenital bilateral absence of the vas deferens or pancreatitis) Identifying genetic variants in individuals where detection rates by targeted variant anal...

Correlates levels of Phosphorylated-TAU protein, Total-TAU protein and AB42 peptide in CSF.

Carbamazepine and its metabolite (10,11- Carbamazepine epoxide) are widely used for control of generalized tonic-clonic, partial-onset, complex and mixed seizure disorders.

This assay enumerates the absolute count of CD34+ hematopoietic progenitor stem cells. Their viability is also assessed. Flow cytometric evaluation of CD34+ cell level is necessary for measuring quantitatively the hematopoietic progenitor cells in dose requirement protocols of stem cell transplantation. Quantification of CD34+ cells is also used...

This is a multiplex PCR which detects the following organisms/resistance genes in infected joint fluid: Anaerococcus prevotii/vaginalis, Clostridium perfringens,  Cutibacterium avidum/granulosum, Enterococcus faecalis (including VRE), Enterococcus faecium (including VRE), Finegoldia magna, Parvimonas micra, Peptoniphilus spp.,  Peptos...

Monitor drug levels for optimal therapy

Supporting, in conjunction with other tests, a diagnosis of Creutzfeldt-Jakob disease in patients with rapidly progressive dementia when other neurodegenerative conditions have been excluded

Zinc is an essential trace element. Subnormal levels are associated with alcoholic cirrhosis, cystic fibrosis, myocardial infarction, acute and chronic infections. High levels may be due to industrial exposure.

Collection time or time interval must be entered in the Ask at order Entry  AOE

May be useful as a secondary screen based on results of ANA test or if ANA IFA is negative and Sjögren syndrome, systemic lupus erythematosus (SLE), systemic sclerosis, or myositis is strongly suspected. SSA-52 (Ro52) and/or SSA-60 (Ro60) antibodies are associated with a diagnosis of Sjögren syndrome, systemic lupus erythematosus (SLE), and syst...

The mean urinary citrate excretion rate in patients with idiopathic calcium urolithiasis has been found to be significantly lower than that of control groups. Hypocitraturia is common in patients with urolithiasis resulting from renal tubular acidosis and in patients with enteric hyperoxaluria. Citrate excretion is low in renal insufficiency.

Investigating suspected Cushing syndrome (hypercortisolism), when a 24-hour collection is prohibitive (ie, pediatric patients). Assisting in diagnosing acquired or inherited abnormalities of 11-beta-hydroxy steroid dehydrogenase (cortisol to cortisone ratio) Diagnosis of pseudohyperaldosteronism due to excessive licorice consumption This t...

This assay is for in vitro diagnostic use under FDA Emergency Use Authorization only and is limited to qualified laboratories designated by CDC.

Carrier Screening

The direct detection of WNV is a valuable tool in determining whether a patient is infected with West Nile virus. PCR is able to detect WNV RNA directly and does not rely on antibody markers of WNV infection, which are produced after RNA is detectable in newly infected individuals.
 

Therapeutic Drug Management

The test identifies disease-causing mutations in individuals affected with Familial Mediterranean Fever (FMF). It can also be used in identifying carriers in high-risk ethnic groups and in prenatal diagnosis.

Preferred test when determining if hypoglycemia is from exposure to metformin. Serum or plasma is the preferred specimen for correlating drug use with hypoglycemia.

HHV-6 is a distinct herpes virus that typically causes a self-limiting illness in patients who are not immunocompromised. In some patients, especially if immumocompromised,

Diagnosis of C6 deficiency Investigation of a patient with an undetectable total complement (CH50) level

Establishing a molecular diagnosis for patients with amyloidosis Identifying variants within TTR known to be associated with amyloidosis, allowing for predictive testing of at-risk family members Identification of a disease-causing variant may assist with diagnosis, prognosis, clinical management, recurrence risk assessment, familial screenin...

Therapeutic drug management

Nortriptyline, the N-demethylated metabolite of amitriptyline, is as effective as imipramine in the treatment of depressive episodes of major depression and bipolar disorder. It may also be useful in dysthymic disorder and atypical depression.

Pinworm (Enterobius vermicularis) is a small thin white worm that lives in the colon and rectum of an infected person. The most common symptom of infection is anal itching, particularly at night, as worms migrate from the intestinal tract of the host and lay their eggs in the anal area. Optimal specimen collection is in the early-morning hours.

OmegaCheck® may be performed on individuals with hypercholesterolemia, hypertriglyceridemia,  hypertension, and/or those high metabolic or cardiovascular risk.

Monitoring treatment of patients with porphyria cutanea tarda

Twenty-four hour urine collections  for oxalate are indicated in patients with surgical loss of distal small intestine, especially those with Crohn's disease. The incidence of nephrolithiasis in patients who have inflammatory bowel disease is 2.6% to 10%.1

Diagnosis of C7 deficiency Investigation of a patient with an undetectable total complement (CH50) level

Detecting deficiencies in the alternative pathway that can cause atypical-hemolytic uremic syndrome, dense deposit disease, and C3 glomerulonephritis ORDERING GUIDANCE This test should be performed prior to treatment initiation and in the absence of therapy with complement inhibitors, such as eculizumab or ravulizumab. Complement inhibitors wi...

Diagnose pheochromocytoma, VMA is of value for evaluation of hypertension, diagnose and follow up neuroblastoma, ganglioneuroma, and ganglioneuroblastoma. Most neuroblastoma patients excrete excess HVA in 24-hour collections. If VMA and HVA are both used in work-up, up to 80% of all cases will be detected.
 

Diagnosis of C8 deficiency Investigation of a patient with an undetectable total hemolytic complement (CH50) level

This test is used for the measurement of Interleukin-2 (IL-2) levels.

Mayo code FFTYC

The current echovirus panel includes serotypes 4, 7, 9, 11, and 30. The echovirus serotypes used in this panel will vary depending upon current epidemiological data available from inhouse isolations CDC reports. Generally, the serotypes used are those most commonly associated with viral meningitis.

Detection of oxycodone and/or oxymorphone

Quantitative HHV-8 DNA PCR can be used to document the presence of the virus as well as track the course of infection.

Diagnosis of C9 deficiency Investigation of a patient with a low total (hemolytic) complement (CH50) level

Monitoring adequacy of serum concentration during amikacin therapy

Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions using 24-hour urine collection specimens Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation...

Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmun...

Diagnosing autoimmune lymphoproliferative syndrome, primarily in patients <45 years of age

Detect the presence of prescribed and illicit drugs for the purpose of medical drug monitoring

11-Deoxycortisol (Compound S) is useful in diagnosing patients with 11-beta-hydroxylase deficiency (second leading cause of congenital adrenal hyperplasia) and primary (adrenal failure) or secondary (hypothalamic-pituitary ACTH deficiency) adrenal insufficiency.

Aiding in the diagnosis of adenovirus infections Human adenoviruses cause a variety of diseases including pneumonia, cystitis, conjunctivitis, diarrhea, hepatitis, myocarditis, and encephalitis.

Aids in diagnosing enterovirus infections

Porphobilinogen levels in the urine should be measured during acute attacks of abdominal pain, extremity pain or paresthesias, tachycardia, nausea and vomiting, neurologic abnormalities, and to investigate characterized by urinary excretion of porphobilinogen and δ-aminolevulinic acid during acute attacks. Increased urinary excretion of por...

Detect use of oxycodone and/or oxymorphone, opioid analgesics

Aids in diagnosing enterovirus infections This test should not be used to screen asymptomatic patients

Adrenal venous sampling procedure is required.

This test is designed to detect heparin-dependent platelet antibodies in the serum from patients suspected of having Heparin-Induced Thrombocytopenia (HIT).

Quantitative results. For those who want to know their exact titer between the reportable range. RFFIT stands for Rapid Fluorescent Foci Inhibition Test. It is a serum neutralization (inhibition) test, which means it measures the ability of rabies specific antibodies to neutralize rabies virus and prevent the virus from infecting cells. The...

Aid in diagnosis of contactin associated protein 2 (CASPR2) antibody disorders associated with acquired neuromyotonia, limbic encephalitis, painful neuropathy, and Morvan syndrome. Use to manage antibody-positive (CASPR2) individual following immunotherapy and/or plasmapheresis.

Assessment of obesity, delayed puberty, and infertility

Measurement of vitamin B7 level

Evaluate industrial exposure

Knowledge of the level of nonesterified fatty acids (NEFA) in blood plasma can be helpful in the diagnosis and management of certain diseases and disorders of metabolism and in the evaluation of prospective causes of hyperlipoproteinemia. A disorder of disease that causes excessive release of a lipoactive hormone (epinephrine, ACTH, GH, etc) can...

Screening for congenital disorders of glycosylation

Evaluate exposure to cyanide

Panorama can detect chronicity of twin gestation. Panorama is a blood-based genetic, prenatal screening test of the pregnant person that screens for common chromosomal conditions that affect a baby’s health. Panorama uses SNP*-based technology to deliver highly accurate results and unique insights for both singleton and twin pregnancies. Panoram...

Plasma plasminogen activator inhibitor, PAI-1 is a major inhibitor of fibrinolysis. The 4G variant (AF386492.2:g.837del) in the PAI-1 (Serpine 1) gene promoter region is associated with an increase in the level of PAI-1 in plasma. Increased levels of PAI-1 in plasma may increase the risk for arterial and venous thrombosis, myocardial infarction...

Therapeutic drug management

Detect use of synthetic cannabinoid drugs

Cystinuria is an autosomal recessive disease in which dibasic amino acids, including cystine, are excreted in excess.

Detect the presence of Shiga-toxin-producing enterohemorrhagic E coli
 

Aid in diagnosis of leucine-rich glioma inactivated 1 protein (LGI1) antibody disorders associated with limbic encephalitis, hyponatremia, and myoclonic movements.  Disorders are rarely associated with tumors. Use to manage antibody-positive (LGI1) individual following immunotherapy and/or plasmapheresis   Leucine-rich, glioma-inacti...

Confirmation of biochemical diagnosis Carrier testing Prenatal diagnosis in at risk pregnancies

Vanillylmandelic acid (VMA) is the major urinary product resulting from the metabolic degradation of catecholamine, norepinephrine and epinephrine. Elevated concentrations of VMA are commonly found in cases of catecholamine secreting tumors such as pheochromocytoma, neuroblastoma, and ganglioneuroma.

Therapeutic Drug Management

·         CSF- Supportive evidence in the evaluation of suspected leptomeningeal carcinomatosis ·         Pancreatic- Supportive evidence in evaluation of pancreatic cystic lesions ·         Pericardial- Supportive evidence ...

This test is appropriate for patients to verify the genetic basis of cancer in families indicative or suggestive of hereditary breast and ovarian cancer syndrome. Results may help in determining treatment and management, as well as identification of at-risk family members.

Appropriate test to rule out acute intermittent porphyria (AIP) and other acute attack types of porphyrias associated with neurologic and/or psychiatric symptoms. Detect porphyrias and porphyrinurias.

First preferred test for screening for catecholamine-secreting tumors in a random urine specimen when requesting both homovanillic acid and vanillylmandelic acid Supporting a diagnosis of neuroblastoma Monitoring patients with a treated neuroblastoma

For the evaluation of patients with recurrent infection for the possibility of IgA deficiency (IgAD). Patients with IgA deficiency may develop antibodies against IgA that make them susceptible to adverse reactions to blood products including intravenous immunoglobulin.

Urinary measurements are appropriate for assessing ongoing exposure to inorganic mercury.

Specimen Source Is required only Oral and Buccal Swab

Adrenal venous sampling procedure is required

Lab orderable only based on reflex testing

In malabsorption syndromes, notably pancreatic insufficiency and Whipple disease, steatorrhea is a prominent feature. Fecal fats can be useful in diagnosis of cystic fibrosis, chronic pancreatitis, neoplasia, or stone obstruction. Also useful in regional enteritis, celiac disease, sprue, and the atrophy of malnutrition. Limitations C8 and...

Useful as a biomarker of various CNS pathologies and as a tumor marker for malignant melanoma.

This test is appropriate when the patient's differential diagnosis includes various hereditary cancer syndromes. The Comprehensive Cancer panel offers increased clinical sensitivity compared to testing for a few genes at a time since it tests for multiple syndromes at once across multiple cancer types. Molecular diagnosis may help in determ...

Quantitative CMV DNA PCR can be used for early detection of CMV reactivation, primary infections, and monitoring response to treatment.

Intended to be used as an aid in identifying species to human pathogenic Plasmodium sp (ie, P falciparum, P knowlesi, P malariae, P ovale, and P vivax)

Used to send to the NYS Department of Health

Evaluating patients with possible inborn errors of metabolism using random urine specimens May aid in evaluation of endocrine disorders, liver diseases, muscle diseases, neoplastic diseases, neurological disorders, nutritional disturbances, renal failure, and burns Includes quantitation of the following amino acids: phosphoserine, phosphoethanol...

Measurement of neopterin in serum

Diagnose cobalamin (vitamin B12) deficiency

Detects antibodies to Salmonella typhi, a common cause of gastroenteritis, diarrhea,  and dysentery.  Antibody results should be confirmed with stool or blood cultures.

Test Includes Coproporphyrins I and III; uroporphyrins; hepatocarboxylporphyrins; hexacarboxylporphyrins; pentacarboxylporphyrins Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute porphyrias, such as ac...

Measurement of factor X antigen concentration

Recommended for the evaluation of individuals with suspected primary biliary cholangitis (PBC) who test negative for anti-mitochondrial antibodies (AMA).

Futhan preservative must be added to samples immediately after collection

Evaluate preoperative patients for succinylcholine (suxamethonium) anesthetic sensitivity, genetic or secondary to insecticide exposure, in appropriate circumstances.

Evaluate toxicity; monitor therapeutic levels
Information
The drug is used in the treatment of petit mal variant (Lennox-Gastaut), akinetic seizures and myoclonic seizures. Serum peak levels occur approximately two hours after oral administration.

Monitoring blood levels of Toxoplasma gondii DNA correlates well with treatment.

Aiding in the diagnosis of Whipple disease, especially for identifying inconclusive or suspicious cases, using whole blood specimens

Insulin-like growth factor II (IGF-II) is a 7.5 kilodalton, 67 amino acid peptide which is thought to mediate some of the actions of growth hormone (GH). IGF-II peptide consists of the A, C, and B chains, and is structurally homologous to IGF-I and proinsulin. IGF-II is secreted by the liver and other tissue and is postulated to have mitogenic a...

Evaluate toxicity; monitor therapeutic levels
 
The drug is used in the treatment of obsessive-compulsive disorder (OCD) and in the treatment of depression and panic attacks.

Detects sequence variants in the NOTCH3 gene in patients with CADASIL (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)

Detect use of THC, a psychoactive drug

Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin fractionation of plasma is useful in diagnosing certain types of porphyrias and excluding porphyrias in patients with chronic renal failure suspected of having a porphyria.

Assessment of drug susceptibility by nucleic acid sequencing of a patient's hepatitis C virus (HCV) to the NS5A inhibitors. Assay should be used for patients with documented HCV genotype 1.

Molecular confirmation of a clinical diagnosis To assist with decisions about treatment and management of individuals with epilepsy Testing of at-risk relatives for specific known mutation(s) previously identified in an affected family member Prenatal diagnosis for known familial mutation(s) in at-risk pregnancies

Proper management is dependent upon early diagnosis; quantitative DNA PCR is a rapid and sensitive tool useful for detecting the virus, tracking the course of the infection, and monitoring response to treatment.

Monitoring the flecainide concentration is used to assure compliance and avoid toxicity of this cardiac drug used to treat ventricular tachcardia and premature cardiac contractions.

Detect Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma spp

  Not for Sputum samples order MTBPCR

Homovanillic acid (HVA) and other catecholamine metabolites (vanillylmandelic acid: VMA and dopamine) are typically elevated in patients with catecholamine-secreting tumors (eg, neuroblastoma, pheochromocytoma, and other neural crest tumors). HVA and VMA levels may also be useful in monitoring patients who have been treated as a result of the ab...

 Molecular confirmation of clinically suspected cases of Huntington disease (HD)   Presymptomatic testing for individuals with a family history of HD and a     documented expansion in the HTT gene

Aiding in the evaluation of patients at-risk for mast cell activation syndrome (eg, systemic mastocytosis, IgE-mediated allergies, or aspirin-exacerbated respiratory disease) using 24-hour urine collections

Mayo test code FGGMC

Establishing a biochemical diagnosis of erythropoietic protoporphyria and X-linked dominant protoporphyria This test is recommended for screening patients for possible erythropoietic protoporphyria and X-linked dominant protoporphyria. In addition, it can be used for evaluation of iron-deficiency anemia and chronic lead intoxication.

Second-order testing to aid in the distinction between a reactive cytosis and a myeloproliferative neoplasm, particularly when a diagnosis of  polycythemia is being considered, using blood specimens

Test has been Discontinued

This test is performed to detect induced chromosome breakage in cells from persons with suspected Fanconi anemia. Diepoxybutane (DEB)-induced chromosome breakage is significantly elevated in Fanconi anemia cells, compared to cells from unaffected individuals.

Primarily used for research and to support attempts to understand the pathogenesis of immune, infectious, allergic, or inflammatory disorders. Cytokine levels may demonstrate diurnal variation. For longitudinal comparison, it is recommended that cytokine levels be determined at the same time of day.

Monitoring Levels

This test is used for measurement of Tumor Necrosis Factor-α levels in serum.

Evaluate fetal distress and placental function in the management of patients facing complications such as preëclampsia, fetal growth retardation, diabetes, Rh immunization, choriocarcinoma, and hydatidiform mole. May be elevated in hydrops fetalis in the presence of a dying fetus. May be low in the presence of a living anencephalic fetus.

Confirmation of diagnosis in patients suspected of having either Prader-Willi syndrome (PWS) or Angelman syndrome (AS) based on clinical assessment or previous laboratory analysis Prenatal diagnosis in families at risk for PWS or AS

Use to detect circulating immune complexes

Measurement of active methotrexate (MTX) metabolites, methotrexate polyglutamates (MTXPGs

test to Esoterix Code 5006349 Estradiol Free, Equilibrium Dialysis, With Total Estradiol, HPLC/MS-MS

Used to send to the NYS Department of Health

PCR test intended for the qualitative detection of RNA from Zika virus in human plasma, serum or urine (collected alongside a patient matched serum or plasma specimen).

Evaluating the nutritional intake and intestinal absorption of essential fatty acids using serum specimens Identifying deficiency of essential and other nutritionally beneficial fatty acids Monitoring treatment of patients with essential fatty acid deficiencies who are receiving linoleic acid (C18:2w6) and alpha-linolenic acid (C18:3w3)

Assessment of drug susceptibility by nucleic acid sequencing of a patient's hepatitis C virus (HCV) to the NS5B inhibitors. Assay should be used for patients with documented HCV genotype 1.

Thiocyanate is used as a biomarker for exposure to cyanides or cyanide-containing chemicals.

The PLAC® test for Lp-PLA2 Activity is an enzyme assay for the in vitro quantitative determination of Lp-PLA2 (lipoprotein-associated phospholipase A2) activity in EDTA plasma and serum. Lp-PLA2 activity is to be used in conjunction with clinical evaluation and patient risk assessment as an aid in predicting risk of coronary heart disease (CHD) ...

Use to detect hemosiderinuria secondary to excess hemolysis.

Detection of Enterocytozoon bieneusi and Encephalitozoon species in fecal and urine specimens to support the clinical diagnosis of microsporidiosis This test is intended to be used for the detection of Enterocytozoon bieneusi and Encephalitozoon species DNA in fecal and urine specimens to support the clinical diagnosis of microsporidiosis. Other...

Zinc protoporphyrin (ZPP) accumulates in erythrocytes as a result of chronic lead absorption or iron deficiency anemia.

Functional testing of red blood cell sensitivity to osmotic stress. Do not use to distinguish between spherocytes  in hereditary spherocytosis and acquired autoimmune hemolytic anemia.

     ** Testing no longer available  **   Replacement test is  LYME 

Ovarian Antibody is found in patients with premature ovarian failure, Addison's disease, and polyendocrinopathy syndromes.

Detection of antiprothrombin antibodies to aid in the diagnosis of antiphospholipid syndrome and to confirm antiprothrombin antibody presence in patients with lupus anticoagulants and hypoprothrombinemia

Evaluate porphyrias, including those involving deficiencies of enzymes that are needed for heme synthesis and chemical porphyrias.

Identify the genetic basis of cancer for individuals who have features and/or a family history consistent with one of the hereditary cancer syndromes described above. Determine appropriate clinical management recommendations based on a molecular diagnosis. Identify family members at-risk to develop features associated with a specific hereditary...

Monitor thrombolytic therapy; evaluate ligneous tissue depositions such as conjunctivitis

Steroid Panel, Comprehensive - This panel identifies all major adrenal steroid hormones and facilitates the diagnosis of the four enzymatic defects associated with congenital adrenal hyperplasia (CAH). All steroids are determined in a single assay by LCMSMS using as little as 0.1 mL serum. Includes 11-Deoxycortisol 17-Hydroxyprogesterone 17-Hyd...

Monitor caffeine concentration in newborns receiving theophylline or caffeine.

Evaluate tuberculous peritonitis

Angiotensin Converting Enzyme (ACE) converts Angiotensin I to Angiotensin II. Angiotensin II exerts a negative feedback control of renin release. Angiotensin II, along with direct renin, is useful in the classification of patients with hypertension.  

The tricyclics are used to treat depression. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.

A timed 24-hour urine collection is the preferred specimen for measuring and interpreting this urinary analyte. Random collections normalized to urinary creatinine may be of some clinical use in patients who cannot collect a 24-hour specimen, typically small children.

Detecting arsenic, cadmium, mercury, and lead exposure and toxicity using 24-hour urine specimen

Pregabalin is commonly used for neuropathic pain and fibromyalgia. This test can be used by physicians to assess compliance and may be clinically useful in patients with renal failure who generally require lower dosages. Therapeutic and toxic ranges are not well defined.

Serum concentrations reflect the synthesis capacity of the liver and may indicate early malnutrition, acute and chronic hepatic disease, advanced chronic renal insufficiency, and cystic fibrosis. Assess nephritic syndrome and protein-losing enteropathy. Due to the short half-life of approximately 12 hours, RBP may be suitable for monitoring the ...

Cystinuria is an autosomal recessive disease in which dibasic amino acids, including cystine, are excreted in excess. Cystine kidney stones account for approximately 1-3% of all kidney stones. Age of onset is often younger than with other types of kidney stones and the recurrence is approximately one-third.

Detect fetal exposure to controlled substances

Evaluate central nervous system involvement of certain inflammatory or B-cell proliferative diseases. This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for...

Cytokines have emerged as molecules of importance in the regulation of many immunologic processes in the cell. The ability to accurately  measure quantitative and qualitative differences in cytokine production is becoming increasingly important to the understanding of normal  and pathological processes.

Horizon provides comprehensive screening using the latest technology, including next-generation sequencing. Horizon screens for genes associated with specific inherited genetic conditions. 274 genes and variants are tested

Use to optimize drug therapy and monitor patient adherence.

The PROMETHEUS® Monitr™ Crohn’s Disease Test is a laboratory-developed test that provides critical information to aid in: •Establishing a baseline measurement of disease activity at initial presentation •Tracking and assessing disease activity and response to therapeutic management •Optimizing treatment management decisions •Evaluating if treatm...

% Fetal Hemoglobin distribution in Hemoglobinopathy evaluation

Monitoring serum concentration during therapy Evaluating potential toxicity The test may also be useful to evaluate patient compliance

MMP-9 is a marker of inflammation, tissue remodeling, wound healing, and mobilization of tissue-bound growth factors and cytokines. Its expression correlates with abnormal collagen deposition accompanying pancreatic cancer, with lymph node metastasis in breast cancer and with regional vessel invasion by giant cell tumor or bone. MMP-9 contribute...

TEST IS DISCONTINUED Reticulin IgG Screen with Reflex to Titer - Anti-Reticulin IgG occurs most frequently in patients with gluten sensitive enteropathy, i.e. celiac disease and dermatitis herpetiformis.

Evaluation of nonspherocytic hemolytic anemia Evaluation of neonatal anemia or jaundice Evaluation of unexplained noninfectious hepatic failure Evaluation of unexplained iron overload Evaluation of unusually severe hemoglobin S trait Evaluation of unusually severe glucose 6-phosphate dehydrogenase deficiency Investigating families with pyru...

Detect use of amphetamine class drugs Test Includes Methamphetamine; Amphetamine; Methylenedioxymethamphetamine (MDMA, Ecstasy); Methylenedioxyamphetamine (MDA)

Tumor sequencing by NGS detecting mutations in 50 genes associated with myeloid malignancies. Mutations often have prognostic significance, may confer resistance to FDA approved therapies, or may qualify patients for late-stage clinical trials.

Molecular confirmation of a clinical diagnosis in symptomatic patients Risk assessment of asymptomatic family members of a proband with cardiomyopathy Differentiation of hereditary cardiomyopathy from acquired (non-genetic) cardiomyopathy Recurrence risk calculation

Assessment of iodine toxicity or recent exposure when a 24-hour urine cannot be collected Monitoring iodine excretion rate as index of replacement therapy when a 24-hour urine cannot be collected

Diagnosis of arsenic intoxication in random urine specimens

ECLT is useful in assessing the fibrinolytic system and monitoring patients on urokinase or streptokinase fibrinolytic therapy.

Isavuconazole is for the treatment of life threatening fungal infections, specifically invasive aspergillosis and invasive mucormycosis.

The CMV Resistance measures: Maribavir, Letermovir, Ganciclovir, Foscarnet, Cidofovir Human Cytomegalovirus (CMV) infections are a major cause of morbidity and mortality among immunocompromised patients. 

Measure histamine that was released in vivo prior to collection of the specimen; evaluate possible systemic mastocytosis.

Screening test for voltage-gated potassium channel (VGKC) antibody receptor complex-associated autoantibodies with test reflex to CASPR2 and LGI1 antibodies. Antibodies are associated with acquired neuromyotonia, limbic encephalitis, painful neuropathy, Morvan syndrome, and rare tumors (eg, thymoma, small-cell lung cancer).

Test is NY State approved.

Test includes: IgG (Dye Test), IgM ISAGA, IgA ELISA

Diagnosis of Fabry disease in male patients Verifying abnormal serum alpha-galactosidase results in male patients with a clinical presentation suggestive of Fabry disease This test is not useful for patients undergoing a work-up for a meat or meat-derived product allergy.

Quantitative HHV-6 DNA PCR can be used for early detection of a primary infection, tracking the course of infection, and monitoring response to treatment; however, quantitative HHV-6 DNA PCR does not differentiate HHV-6 viremia from patients with chromosomally integrated HHV-6, a relatively uncommon congenital occurence that has not been conclu...

Horizon provides comprehensive screening using the latest technology, including next-generation sequencing. Horizon screens for genes associated with specific inherited genetic conditions. 421 genes and variants are tested

Determination of a clinical diagnosis  Identification of gene implicated in genetic disease  Recurrence risk assessment XomeDxPlus includes whole exome sequencing as well as mitochondrial genome sequencing and deletion testing. For more information on the mitochondrial genome sequencing and deletion component of the XomeDxPlus testing...

Reduced or absent GHBP is found in GH insensitivity due to inactivating receptor binding mutations as typified by Laron dwarfism. The most clinically relevant use of GHBP measurements is to confirm suspected Laron dwarf GH insensitivity due to genetic GH receptor defect. Other forms of GH receptor insensitivity, however may have normal or high G...

Helicobacter pylori has been associated with peptic ulcer disease and cancers of the gastrointestinal tract. In 1994, the U.S. National Institute of Health Consensus Development Conference concluded that H. pylori infection represents the major cause of peptic ulcer disease and antimicrobial treatment is recommended for patients with the confirm...

Detect presence of clonazepam

Patients with chronic lymphocytic leukemia have variable outcome. Some live with their disease for more than 25 years and some die within a few years. ZAP70 can predict patients who have aggressive disease and need aggressive therapy.

Surgical treatment of hyperparathyroidism relies on the ability to accurately identify parathyroid tissue. The use of fine-needle aspirate (FNA) with measurement of intact parathyroid hormone (PTH) levels in suspected parathyroid cysts or adenomas is used to identify parathyroid tissue and has been proven to be a useful surgical adjunct in the ...

Pancreatic cancer diagnosed at an early age Multiple cancers in one person (such as pancreatic cancer and breast cancer) Multiple relatives diagnosed with pancreatic cancer and/or related cancers (including breast, colon, melanoma etc.) on the same side of the family and spanning multiple generations

XomeDx, or whole exome sequencing (WES), can be used to identify the underlying molecular basis of a genetic disorder in an affected individual. The XomeDx test is different from other types of genetic diagnostic tests in terms of the number of genes that are sequenced simultaneously. The XomeDx test targets the protein-coding regions of the hum...

Confirm presence of disease; not recommended for initial testing.

Cytochrome P450 2D6 (CYP2D6) is a drug-metabolizing enzyme involved in the metabolism of more than 65 clinically important drugs including some antidepressants, anti-psychotics, opioids, beta-blockers, antiemetics, atomoxetine and tamoxifen. Individuals with some variant CYP2D6 alleles may experience a reduced therapeutic response and may be at ...

Aiding the diagnosis of arboviral encephalitis (California [LaCrosse], St. Louis, Eastern equine, and Western equine encephalitis)

ALA is a precursor to uroporphyrin, coproporphyrin, and protoporphyrin. Concentrations of ALA are greatly increased in many patients with acute neurological forms of porphyrias and in some patients with chronic alcohol abuse.

Identify the genetic basis of breast cancer for individuals who have features and/or a family history consistent with one of the hereditary cancer syndromes  described above. To possibly help determine appropriate clinical management recommendations based on a molecular diagnosis. Identify family  members at-risk to develop features as...

Alpha-1-Acid Glycoprotein - Alpha-1-acid glycoprotein is an acute phase reactant found in a number of conditions. It migrates with the alpha-1 proteins on serum protein electrophoresis.

Acceptable test for determining chronic exposure to organophosphate insecticides. Erythrocyte cholinesterase is measured to diagnose organophosphate and carbamate toxicity and to detect atypical forms of the enzyme. Cholinesterase is irreversibly inhibited by organophosphate insecticides and reversibly inhibited by carbamate insecticides. Serum...

Homovanillic acid (HVA) measurement in urine is used for screening children for catecholamine-secreting tumors such as neuroblastoma, pheochromocytoma, and other neural crest tumors and monitoring those who have had treatment for these tumors. HVA measurement is also useful to diagnose children with disorders of catecholamine metabolism such as...

Diagnosing Pompe disease, when used in conjunction with acid alpha-glucosidase enzyme activity assays and molecular genetic analysis of the GAA gene Monitoring Pompe patients on enzyme replacement therapy May support the diagnosis and monitoring of other glycogen storage disorders; however, glucotetrasaccharide (Glc4) excretion appears to b...

Measurement of total and free testosterone is key in diagnosis of androgen excess or deficiency. Free testosterone is best measured by equilibrium dialysis, while total testosterone is measured by HPLC with tandem mass spectrometry.1-3 Free testosterone is estimated in this profile using these recommended techniques. Tritiated testosterone is a...

T3 measurements are used to diagnose hyperthyroidism. This test can also be used to clarify thyroid status in the presence of possible protein-binding abnormalities

Detect use of opiate and opioid class drugs Please note: this test includes both Buprenorphine(Suboxone) and Fentanyl

This is for Transplant only! send samples to Renal Transplant                             Att: Leandra Osborne                             400 Community Drive

Molecular confirmation of a clinical diagnosis in symptomatic individuals Risk assessment of asymptomatic family members of a proband with  arrhythmia Differentiation of hereditary arrhythmia from acquired (non-genetic) arrhythmia Recurrence risk calculation

Monitoring of compliance utilizing tramadol Detection and confirmation of the illicit use of tramadol

Molecular confirmation of a clinical diagnosis

An aid in the diagnosis of congenital herpes simplex virus (HSV) infection in patients younger than 35 days old through the recovery of HSV using viral culture (shell-vial)

Diagnosis of Smith-Lemli-Opitz syndrome (7-dehydrocholesterol reductase deficiency) Smith-Lemli-Opitz syndrome (SLO) is a multiple congenital anomaly disorder caused by defective cholesterol biosynthesis due to deficiency of the enzyme 7-dehydrocholesterol (7-DHC) reductase. Clinical variability even within families has been noted and severity...

Y. enterocolitica is associated with a wide spectrum of clinical manifestations, including enteritis, colitis, and reactive arthritis. Specific IgG and IgA antibodies are typically present following acute infection.

Assessing and adjusting dosage for optimal therapeutic level
 
Assessing toxicity

Detect use of benzodiazepine class drugs

Assessing achievement of optimal therapeutic concentrations
 
Assessing potential toxicity

Used to send to the NYS Department of Health

Cytochrome P450 2C19 (CYP2C19) is a drug-metabolizing enzyme involved in the metabolism of several clinically important drugs including the platelet aggregation inhibitor clopidogrel, the tricyclic antidepressants amitriptyline and nortriptyline, the selective serotonin reuptake inhibitors citalopram and sertraline, and some proton pump inhibito...

As the primary mediator of endogenous fibrinolysis, elevated tPA levels are strongly associated with an increased risk of arterial vascular disease and have been shown to indicate risk of future myocardial infarction.

Use to identify patients who may be at risk for developing Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) prior to treatment with carbamazepine (CBZ). This test has been recommended for patients of Asian descent who are being considered for carbamazepine therapy. The utility of this test for patients of other ethnic backgroun...

Differential diagnosis of hypercalcemia

Aiding in the diagnosis of neuroinvasive Lyme disease or neuroborreliosis due to Borrelia species associated  with Lyme disease (eg, Borrelia burgdorferi, Borrelia garinii, Borrelia afzelli) Requires CSF and Serum

Determines viral phenotype and genotype resistance to three classes of commonly prescribed antiretrovial drugs: nucleoside reverse transcriptase inhibitors(NRTI), nonnucleoside reverse transcriptase inhibitors (NNRTI), and protease inhibitors (PI). Viral replication capacity is also included.   This procedure should be used for patients w...

Fluoxetine may be indicated as initial therapy in patients with concurrent obsessive-compulsive disorder.

Detect the presence of illicit drugs

Aid in evaluation of patient with allergic signs and symptoms, such as anaphylaxis; may assist in diagnosing and monitoring of mast-cell activation disorders.

Assessment of liver fibrosis severity for HCV patients Aids in in the detection, staging, and monitoring of liver fibrosis. The simple blood test is noninvasive and provides a quantitative fibrosis score to help physicians risk stratify and monitor patients. •Differentiates between F0-F1 and F2-F4 liver fibrosis1 •Validated with samples from 348...

Biochemical diagnosis of inborn errors of mitochondrial fatty acid oxidation, including deficiencies of medium-chain acyl-Co-A dehydrogenase, long-chain 3-hydroxyacyl-Co-A dehydrogenase, very long-chain acyl-Co-A dehydrogenase, and glutaric acidemia type 2

Primarily for research and to support attempts to understand the pathogenesis of immune, infectious, allergic, or inflammatory disorders.

Detect Oxycodone Level

Urinary measurements are appropriate for assessing ongoing exposure to inorganic mercury.  

Arsenic is used in some pesticides and industrial applications.

This assay measures the absolute count and viability of CD3+ T-cells. It can be used in the following clinical scenarios. First, the CD3 absolute count is measured in stem cell transplant products when it is important that the number of CD3 T cells present is as low as possible (rare event testing), to prevent Graft versus Host disease. Second,...

Detect HIV-1 coreceptor tropism; determine eligibility for CCR5 antagonist therapy such as Selzentry™ (maraviroc).

Detect heroin metabolite
 
This assay is designed for pain management. It is not intended for workplace testing and does not comply with state regulatory workplace testing programs.

Aids in the Diagnosis of a disease or infestation may be achieved by recovery and identification of the intact arthropod/insect.

Monitoring serum concentration during therapy Evaluating potential toxicity The test may also be useful to evaluate patient compliance

An adjunct in the evaluation of possible prostatic malignancy and useful in monitoring therapeutic progress This test is not the same as Acid Phosphatase. Values obtained with different assays should not be used interchangeably in serial testing. It is recommended that only one assay method be used consistently to monitor each patient's cours...

Anti-Ri can be detected in patients with theparaneoplastic opsoclonus/myoclonus syndrome. Neoplasms most often associated with Anti-Ri include breast cancer, gynecological cancers, and small cell lung cancer

Therapeutic assessment typically includes measurement of both the parent drug (diazepam) and the active metabolite (nordiazepam).

Ruling out a diagnosis of narcolepsy.

Detect presence of flunitrazepam, a potent sedative-hypnotic with a reputation as a “date-rape” drug.

Detect MDMA (methylenedioxymethamphetamine) and related compounds in urine

Therapeutic drug management; detect presence of ketamine

Determining class I human leukocyte antigens (HLA) on specimens for those patients who have become refractory to platelet transfusions and identify potential disease association Human leukocyte antigens (HLA) are regulators of the immune response. HLA class I typing is used to identify HLA-matched platelets for alloimmunized refractory patien...

The concentration of both procainamide and NAPA levels are monitored to assure adequate therapeutic levels of procainamide are achieved and to avoid toxicity.

Primarily used for research and to support attempts to understand the pathogenesis of immune, infectious, allergic, or inflammatory disorders.

This test can be used to confirm a suspected diagnosis of Hereditary Spherocytosis (HS). HS is a common inherited hemolytic anemia characterized by the presence of spherical erythrocytes (spherocytes). HS is diagnosed based on family history and clinical features, along with clinical laboratory tests, including peripheral smear examination, osmo...

Isoagglutinins are antibodies produced by an individual that cause agglutination of RBCs in other individuals. People possess isoagglutinins directed toward the A or B antigen absent from their own RBCs. For example, type A or O individuals will usually possess anti-B. The anti-B is formed in response to exposure to B-like antigenic structures f...

Confirm and quantify the presence of hepatitis D virus.

Monitoring serum concentration during therapy..... Evaluating potential toxicity..... May be useful to evaluate patient compliance

For Immigtation Status

The assay is intended to help physicians identify patients experiencing “silent inactivation” and/or rapid clearance so as to ensure that adequate asparaginase activity is present during treatment.

Molecular confirmation of a clinical diagnosis

Monitoring its level is important to opitmize therapy, to avoid toxicity, and to assure compliance.

Therapeutic drug management

Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.
 

Detecting toxic thallium exposure in whole blood specimens

Determining class II human leukocyte antigens (HLA) antigens to identify potential disease association and as markers for drug hypersensitivity.

Molecular confirmation of a clinical diagnosis Identification of at-risk family members Recurrence risk Assist with management/treatment decisions

Evaluate exposure to titanium

Colorectal or endometrial cancer diagnosed under 50 years of age

Evaluating children with autoimmune central nervous system disorders using spinal fluid specimens.

Detect use of cocaine class drugs

Detect the presence of circulating pemphigus and bullous pemphigoid antibodies in sera.

Detection of alpha defensins 1-3, human host response proteins, in synovial fluid of adults with a total joint replacement who are being evaluated for revision surgery This test is not intended to be used to determine timing for reimplantation in 2-stage procedures.

Determines viral phenotype and genotype resistance to three classes of commonly prescribed antiretrovial drugs: nucleoside reverse transcriptase inhibitors(NRTI), nonnucleoside reverse transcriptase inhibitors (NNRTI), and protease inhibitors (PI). Viral replication capacity is also included.

Macroamylase is a laboratory, not a clinical entity. Amylase can complex with immunoglobulins or other high molecular weight proteins.

Includes quantitation of the following amino acids: phosphoserine, phosphoethanolamine, taurine, threonine, serine, hydroxyproline, asparagine, glutamic acid, 1-methylhistidine, 3-methylhistidine, argininosuccinic acid, carnosine, anserine, homocitrulline, alpha-aminoadipic acid, gamma-amino-n-butyric acid, beta-aminoisobutyric acid, alpha-amino...

To assist in distinguishing whether a positive urine THC test is exclusively the result of CBD use.

Detect the presence of ibuprofen, a nonsteroidal anti-inflammatory drug

An auxiliary test in the diagnosis of Creutzfeldt-Jakob disease

Detecting and identifying bacteria (including mycobacteria) from normally sterile sources, including synovial fluid; body fluids such as pleural, peritoneal, and pericardial fluids, cerebrospinal fluid; and both fresh and formalin-fixed paraffin-embedded tissues This test is not recommended as a test of cure because nucleic acids may persis...

This test is used to aid in the diagnosis and monitoring of patients with mucopolysacchariodoses (MPS) types I, II, III, IV, VI, and VII.

Urinary lead concentrations may be used to monitor detoxification therapy.

Disopyramide(Norpace) is useful in treating patients with cardiac arrhythmias and tachcardia. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.

Monitor manganese exposure

Molecular confirmation of a clinical diagnosis  Testing of patients suspected of having a mitochondrial disorder. 

Confirmation of a clinical diagnosis in symptomatic patients Risk assessment for asymptomatic family members of a proband with LQTS Differentiation of hereditary LQTS from acquired (non-genetic) causes of LQTS

Confirmation of a clinical diagnosis Carrier testing for individuals with a known familial TSC1 or TSC2 mutation Prenatal diagnosis in at-risk pregnancies

Assessment of adults with cognitive impairment being evaluated for Alzheimer disease (AD) and other causes of  cognitive impairment These assays should not be used to predict the development of dementia or other neurologic conditions or to monitor  response to therapies.

Use to diagnose Gaucher disease only; not indicated for carrier screening.

Futhan preservative must be added to samples immediately after collection.

Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis

Detect use of abused, prescribed, and over-the-counter drugs

Preferred test for the diagnosis of biotinidase deficiency Follow-up testing for certain organic acidurias

Therapeutic drug management

Candida auris has emerged as a significant fungal pathogen, especially in nosocomial settings. The ability of C. auris to colonize both the patient and environment, as well as common antifungal resistance, makes it an organism of particular concern from an infection control perspective. Screening of patients for the presence of C. auris can assi...

Therapeutic drug management

L265P mutation in the MYD88 gene is found in approximately 90% of WaldenstrÖm macroglobulinemia and IgM-expressing lymphoplasmacytic lymphoma (LPL). There is a low incidence of L265P MYD88 mutation in other systemic CD5-negative B-cell lymphoproliferative disorders including atypical chronic lymphocytic leukemia, nodal marginal zone lymphoma (M...

May be useful for exposure monitoring or investigation. Copper concentrations in red blood cells (RBCs) reflect the intracellular stores and general homeostasis of copper.

The diagnosis of chronic pancreatitis depends upon the demonstration of functional impairment of the pancreas. Impairment is determined by several means, two of which are: 1. Direct measurement of exocrine secretion into the duodenum after stimulation by a standard meal or after stimulation by intravenous secretin/pancreozymin; 2. The direct mea...

Molecular confirmation of a clinical diagnosis To assist with decisions about treatment and management of individuals with ataxia

Next-generation sequencing (NGS) identifies both the growth potential of clinically relevant microbes in a sample, and the relative abundance of those microbes. 

Detect use of cocaine, a stimulant drug

This test in only for Rapid Response Labs only   Not for Outpatients

Assessment of iodine toxicity or recent exposure in a 24-hour urine collection Monitoring iodine excretion rate as index of replacement therapy

Assessment of iodine toxicity or recent exposure in a 24-hour urine collection Monitoring iodine excretion rate as index of replacement therapy

Detect use of gabapentin, an anticonvulsant and neuromodulator

Rivaroxaban is an oral factor Xa inhibitor that is indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It is also indicated for the treatment, prophylaxis, or the reduction in the risk of reoccurrence of deep vein thrombosis (DVT) or pulmonary embolism (PE). Rivaroxaban does not need to ...

Detecting toxic thallium exposure in 24-hour urine specimens

Detection of myocardial Antibodies suggests that a patient's heart disease may have an immunologic component. Myocardial Antibodies are found in the serum of patients with various cardiomyopathies, especially idiopathic dilated cardiomyopahty, myocarditis, rheumatic fever, and Dressler's Syndrome.

Monitor inflammation caused by asthma. Optimize corticosteroid treatment in asthmatic patients.

Identification of Nocardia species by PCR will allow for a more rapid turnaround time enabling physicians to know to  treat specifically for Nocardia rather than another bacteria.

Primarily used for research and to support attempts to understand the pathogenesis of immune, infectious, allergic, or inflammatory disorders.

Detect presence of the kratom alkaloid mitragynine, a mood altering opioid receptor agonist, which has both stimulant and opioid effects.

The MaterniT Genome test provides comprehensive chromosome copy number analysis including unbalanced derivatives and, information about deletions or duplications of chromosome material 7 Mb or larger, as well as analysis of seven clinically relevant microdeletions less than 7 Mb in size.

Aid in evaluation of patient with allergic signs and symptoms, such as anaphylaxis. May assist when diagnosing and monitoring mast-cell activation disorders or when evaluating histamine production over a longer time frame.

Molecular confirmation of a clinical diagnosis To assist with decisions about treatment and management Testing of at-risk relatives for specific known variant(s) previously identified in an affected family member Prenatal diagnosis for known familial pathogenic variant(s) in at-risk pregnancies Genetic counseling, especially recurrence risk and ...

As a prognostic indicator in patients with newly diagnosed acute myelogenous leukemia with normal karyotype and no FLT3 variant and as a leukemia-specific marker of minimal residual disease. Testing Algorithm Both DNA and RNA are extracted. The assay is composed of 2 parts, an RNA-based, sensitive quantitative reverse transcription real-time pol...

   Inactive  do not order   Aid in the diagnosis of parainfluenza viral infections.   Limitations Complement fixation testing for this virus group is somewhat less sensitive than HI or neutralizaiton testing

Evaluating patients with chronic myelogenous leukemia and Philadelphia chromosome positive B-cell acute lymphoblastic leukemia receiving tyrosine kinase inhibitor (TKI) therapy, who are apparently failing treatment Preferred initial test to identify the presence of acquired BCR-ABL1 mutations associated with TKI-resistance.

Butalbital, short-acting barbiturate with hypnotic properties, is used in combination with other drugs such as acetaminophen, salicylate, caffeine, and codeine.

The Pseudocholinesterase phenotype can be determined by analysis of Pseudocholinesterase and the percent inhibition by Dibucaine.  

A circulating biomarker in myopathy-related mitochondrial disease as well as other conditions Investigation of patients suspected of having a mitochondrial myopathy This assay is not suitable for carrier detection.

Investigating the differential diagnosis for patients with water balance disorders, including diabetes insipidus, in  conjunction with osmolality and hydration status May aid in the evaluation of cardiovascular disease in conjunction with other cardiac markers

A positive titer (≥1:4) by anticomplement immunofluorescence (ACIF) indicates a history of past infection by Varicella-Zoster virus (VZV). This antibody is usually detectable within 2 days after the onset of rash and is, thereafter, detectable for life. Conversely, the absence of detectable antibody can be used as evidence of susceptibility to v...

Used as a confirmation test for Toxoplasma infections

Transforming Growth Factor (TGF) plays a crucial role in tissue regeneration, cell differentiation, embryonic development, and regulation of the immune system. Transforming growth factor beta is found in hematopoietic (blood-forming) tissue and initiates a signaling pathway that suppresses the early development of cancer cells. It enhances the ...

Confirmation of a clinical diagnosis in symptomatic patients Risk assessment of asymptomatic family members of a proband with Brugada syndrome Recurrence risk calculation Differentiation of hereditary BrS from other acquired or genetic heart conditions Prenatal diagnosis in families with a known mutation

Toxoplasma gondii is highly problematic when primary infection occurs during the first trimester of pregnancy, often leading to fetal death or when reactivation occurs in immunocompromised patients, leading to life-threatening disease including encephalitis and extracerebral toxoplasmosis. Onset of disease in most patients is preceded by an i...

Confirmation of clinical diagnosis Identification of at-risk family members Can assist with management/treatment decisions

Glutathione is a tripeptide and is the primary regulator of cellular redox states. Glutathione exists primarily in its reduced form (GSH), which upon oxidation forms the dimer, glutathione disulfide (GSSG). GSH can also form disulfide bridges with proteins as a result of oxidation or enzyme catalyzed reactions, giving rise to protein-bound gluta...

Parvovirus B19 manifests itself as an acute or chronic hematological disorde r in immunocompromised patients. It can cause persistent anemia, sometimes associated with leukopenia and thrombocytopenia. Pediatric transplant patients are at risk for chronic infections, which can be associated with lung and/or renal disorders. Quantitative DNA PC...

Detect use of zolpidem, a non-benzodiazepine sedative/hypnotic

Molecular confirmation of a clinical diagnosis To assist with decisions about treatment and management of individuals with epilepsy Testing of at-risk relatives for specific known variant(s) previously identified in an affected family member Prenatal diagnosis for known familial pathogenic variant(s) in at-risk pregnancies GeneDX code 921

Analysis of midtrimester amniotic fluid for detection of open neural tube defects and ventral wall defects Test Includes Detection of AChE. The reflex to fetal hemoglobin (Hb F) will be performed, if necessary, to ascertain false elevations of amniotic fluid AFP.

Therapeutic drug management

Molecular confirmation of a clinical diagnosis To assist with decisions about treatment and management of individuals with autism or intellectual disability Testing of at-risk relatives for specific known variant(s) previously identified in an affected family member Prenatal diagnosis for known familial pathogenic variant(s) in at-risk pregnancies

Diagnosis of chromosome abnormalities, including aneuploidy, structural abnormalities, and balanced rearrangements

Predicting responsiveness of genotype 1 hepatitis C viral infections to combined pegylated-interferon and ribavirin-based therapies. This test does not detect variants other than the rs12979860 single-nucleotide variant.

Possible use in evaluating patients with autoimmune encephalitis, stiff-person syndrome, autoimmune ataxia, autoimmune epilepsy, and other acquired central nervous system disorders affecting gabaminergic neurotransmission

Cancer at a young age, such as breast or colon cancer Multiple cancers in one person, either of the same origin (such as two separate colon cancers) or of different origins (such as breast cancer and ovarian cancer) Diagnosis of certain rare cancers, such as ovarian or male breast cancer Multiple relatives diagnosed with the same or related canc...

This test includes analysis for methanol, ethanol, isopropanol, and acetone. Detection and quantitation of acetone, methanol, isopropanol, and ethanol in serum Quantification of the concentration of ethanol in serum correlates with degree of intoxication Evaluation of toxicity to the measured volatile substances

Quantitative PCR can be used to detect the presence of the virus as well as track the course of infections and response to treatment.

Evaluation of patients with nephrotic syndrome and pancreatitis
Alpha-2-macroglobulin is a protease inhibitor and is one of the largest plasma proteins. It transports hormones and enzymes, exhibits effector and inhibitor functions in the development of the lymphatic system, and inhibits components of the complement system and hemostasis syste...

Preferred enzymatic test for detection of arylsulfatase A deficiency This test is not suitable for carrier detection.

Comprehensive serum antibody profile combines 5 serological markers (DGP IgA, DGP IgG, tTG IgA, EMA IgA, and total serum IgA) as an aid in the diagnosis of celiac disease.

Mayo Code: FGTIA

Test Includes Aldosterone, serum; corticosterone; deoxycorticosterone (DOC), serum; 18-hydroxycorticosterone, serum

Diagnosis of galactose-1-phosphate uridyltransferase deficiency, the most common cause of galactosemia Confirmation of abnormal state newborn screening results

Monitoring of pentobarbital therapy treatment

Therapeutic drug management

A personal and/or family history of one or more paragangliomas or pheochromocytomas A pattern of cancer in which individuals with similar or related cancers (see table below) are on one side of the family and spanning multiple generations GeneDx code B395-5

ADMA and SDMA may be measured in individuals with multiple risk factors for the development of cardiovascular disease.

Evaluate exposure to benzene

Adrenal venous sampling procedure is required.

Specimen Type (All Patients including Newborns / Infants): Blood obtained by capillary, (finger-stick for adult and pediatric patients; heel-stick for newborns and infants less than six months of age, children between 6 and 12 months of age, the decision to use the finger instead of the heel must be based on the child’s weight) venous, and arter...

Suspected deletion/duplication syndrome Family history of known or suspected chromosome imbalances Abnormal maternal serum screening Advanced maternal age The prenatal targeted CMA focuses on detection of CNVs in approximately 150 cytogenetically relevant regions, including common or novel microdeletion and microduplication syndromes. Deleti...

XomeDx, or whole exome sequencing (WES), can be used to identify the underlying molecular basis of a genetic disorder in an affected individual and is best suited for patients who have a genetic condition that routine genetic testing has not been able to identify. Determination of a clinical diagnosis Identification of gene implicated in genet...

Detect use of synthetic cathinone class drugs

A rapid screening test for potential sibling donors for blood & marrow transplant patients. The test must be ordered for the patient and each potential donor. Versiti Code 2380

Therapeutic drug monitoring.

The KCT is a sensitive screening test of lupus anticoagulants (LA) in patients with a history of thrombosis.

Detect use of buprenorphine, a semi-synthetic opioid medication

Detect use of barbiturate class drugs Cutoff = 100

Molecular confirmation of clinically suspected cases of sporadic or familial spinobulbar muscular atrophy (SBMA) Presymptomatic testing for individuals with a family history of SBMA and a documented expansion in the androgen receptor (AR) gene

In the context of normal cytogenetics AML patients with biallelic CEBPA mutations have a favorable prognosis. Risk adopted treatment strategies can be adopted for such patients.

Diagnosis of arsenic intoxication using 24 hour urine specimens. Total arsenic will be performed first. If the total arsenic concentration is 10 mcg/L or greater, then speciation will be performed and reported. If total arsenic is below 10 mcg/L, total arsenic will be reported as less than 10 mcg/L and speciation will not be performed.

Monitor industrial exposure to selenium

Zinc measurements are used to detect and monitor industrial, dietary, and accidental exposure to zinc. Also, zinc measurements may be used to evaluate health and monitor response to treatment.

Maternal serum AFP is a screening test for Open Neural Tube Defects (ONTD’S) such as Open Spina Bifida (OSB) and Anencephaly.  The test may also detect approximately 60% of Ventral Wall Defects (VWD). A positive result means that further diagnostic testing may be offered to the pregnant woman to determine if a structural defect is p...

2T Quad Screen is a second trimester screening test for the two most common fetal aneuploidies,trisomy 21 and trisomy 18.  The test also detects Open Neural Tube Defects (ONTD’S) such as Open Spina BifidaOSB) and Anencephaly (see 2T AFP). 2T Quad Screen incorporates the maternal serum markers AFP, free ßhCG, Inhibin A and uE3.

 High Grade (Gleason 7+) Prostate Cancer Risk Evaluation The 4K score should only be ordered when medically reasonable for consideration of biopsy after excluding benign    cause of PSA elevation.   Limitation an Exclusions for the 4Kscore Do not use this test for a patient:   1) With a previous diagnosis of prostate...

The aGVHD Post-Treatment Algorithm for use after systemic treatment for aGVHD has been initiated.

The aGVHD Pre-Symptomatic Algorithm for use post-transplant and before the patient shows onset of aGVHD symptoms.

The aGVHD Symptomatic Onset Algorithm for use post-transplant, and after the patient displays symptoms of aGVHD

Detect use of ethanol

Requires coordination with CareDx and communication with the local laboratory prior to collection. AlloMap Molecular Expression Testing (the AlloMap Test) is an In Vitro Diagnostic Multivariate Index Assay (IVDMIA) test service, performed in a single laboratory, assessing the gene expression profile of RNA isolated from peripheral blood mononucl...

Requires coordination with CareDx. AlloSure-Heart measures a biomarker in your blood called donor-derived cell-free DNA (dd-cfDNA). When dd-cfDNA increases, it provides an early warning sign that there could be an issue with the heart.

Measurement of mid-trimester amniotic AFP fluid for detection of open neural tube defects and ventral wall defects. Samples with AFP values >= 2.0 MoM will reflex to detection of acetylcholinesterase and fetal hemoglobin. 

This assay detects the presence of the following autoantibodies by multiplex flow immunoassay: • dsDNA Antibodies• Smith (Sm) Antibodies• Chromatin Antibodies• Jo-1 Antibodies• Ribosomal P Antibodies• RNP Antibodies• Sjogren's SSA-A (Ro)• Sjogren's SS-B (La)• Centromere B Antibodies• Scl-70 Antibodies

Leukemias and lymphomas are characterized by the presence of clonal B-or T-cell populations. Rearrangement of the antigen receptor genes occur during the ontogeny of B and T cell lymphocytes. The rearrangements are unique in length and sequence for each cell. Immunoglobulin heavy chain (IGH) and Kappa Light chain (IGK) gene rearra...

***NOTE: This is a time sensitive assay and must be in the lab within 24 hours of draw*** Assess B cell subsets of immunodeficiencies. Support the diagnosis of common variable immune deficiency (CVID) and assist in predicting the clinical phenotype. Assess B cell reconstitution after bone marrow or hematopoietic stem cell transplantation.

Support a diagnosis of congestive heart failure (CHF) B-type natriuretic peptide (BNP), also referred to as brain natriuretic peptide, is a member of a family of structurally similar peptide hormones that  includes atrial natriuretic peptide.1 BNP is a 32-amino-acid peptide that contains a 17-amino-acid ring structure that is formed as the ...

Is useful for establishing clonality of B-cell neoplasms and in the identification of minimal residual disease or early recurrence in patients with a previous diagnosis of a B-cell neoplasm. It can be used in association with the immunoglobulin kappa light chain

Partner Screening

Confirming a clinical diagnosis of Beckwith-Wiedemann syndrome (BWS) or Russell-Silver syndrome (RSS) Prenatal diagnosis if there is a high suspicion of BWS/RSS based on ultrasound findings or in families at risk for BWS/RSS. Genetics Information: This test detects deletions/duplications and determines methylation status in the BWS/RSS gene clus...

Blood culture bottles are incubated for five days. First time positive bottles (within a seven day period) will have molecular blood culture identification performed by multiplex PCR. This multiplex PCR assay detects the following organisms and antibiotic resistance genes: Acinetobacter calcoaceticus-baumannii complex, Bacteroides frag...

ASSAY DESCRIPTION: BRAF V600 mutations are associated with sensitivity to BRAF inhibitors while NRAS mutations have a prognostic value. The NRAS/BRAF Mutation assay, performed on the Biocartis Idylla™ System using exclusively FFPE samples (Slides), combines the detection of mutations in codons 12, 13, 59, 61, 117, 146 of the NRAS gene, and mutat...

ASSAY DESCRIPTION: Mutations in the BRAF gene have been associated with various cancers, including colorectal cancer, malignant melanoma, thyroid carcinoma, NSCL carcinoma, and adenocarcinoma of the lung. The most frequently reported BRAF mutation is an activating missense mutation in which the amino acid glutamic acid is substituted for valine ...

Diagnosis of C1 deficiency Investigation of a patient with an absent total complement level

Investigation of a patient with a low (absent) hemolytic complement

Diagnosis of C4 deficiency Investigation of a patient with an undetectable total complement level

Diagnosis of C5 deficiency Investigation of a patient with an undetectable total complement level

The most common mutation in patients with myeloproliferative neoplasms polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) is JAK2 V617F.  CALR somatic mutations are seen in a large subset of patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF) who lack JAK2 and MPL mutations. CALR m...

An indicator of chronic alcohol abuse This test is not appropriate for screening patients for congenital disorders of glycosylation

The determination of insulin in serum is primarily used for the diagnosis of glycemic disorders in diabetic and pre-diabetic patients in the assessment of insulin resistant syndromes. Insulin is synthesized by the pancreatic beta cell as a precursor,  proinsulin. Proinsulin is processed to insulin and C-peptide, a contiguous peptide between...

Therapeutic drug management

Evaluating for the risk of major adverse cardiovascular events within the next 1 to 5 years
MI-Heart Ceramides is a blood test that measures risk for adverse cardiovascular events and quantifies plasma ceramides. Plasma ceramides are predictors of adverse cardiovascular events resulting from unstable atherosclerotic plaque.

Chlorpromazine is a phenothiazine for treating psychosis and Tourett's syndrome. Monitoring it's level is important to optimize therapy, to avoid toxicity, and to assure compliance.

Detecting the presence and titer of a specific factor inhibitor directed againstcoagulation factor VIII for patients on emicizumab (Hemlibra) Detecting the presence and titer of an inhibitor directed against factor VIII This test is not useful for detecting the presence of inhibitors directed against other clotting facto...

Evaluation of oncology specimens for chromosomal abnormalities associated with hematologic malignancies for diagnostic and prognostic purposes.

The CMV inSIGHT™ T Cell Immunity Panel measures the strength of T cell responses to Cytomegalovirus (CMV) specific antigens. It evaluates and reports the activity of CD4 and CD8 T cell responses independently. Effective T cell immunity against CMV is a factor in controlling CMV viral latency. CMV can affect patients with weakened immune system...

Cryptosporidium and Giardia are two of the most frequent causes of parasitic intestinal diseases.  Both organisms are found throughout the world. Transmission is usually through the ingestion of  contaminated food or water. Giardiasis in humans is caused by the protozoan parasite Giardia duodenalis (also known as  Giardia intes...