HLA Class A-B-C Disease Association

HLA Class A-B-C Disease Asso.

Determining class I human leukocyte antigens (HLA) on specimens for those patients who have become refractory to platelet transfusions and identify potential disease association Human leukocyte antigens (HLA) are regulators of the immune response. HLA class I typing is used to identify HLA-matched platelets for alloimmunized refractory patients and identify presence of HLA antigens associated with a number of diseases or as drug hypersensitivity markers Class I HLA antigens include A, B, and C loci. This assay is designed to provide low-to-medium resolution for HLA class I typing (A, B, C). Low-to-medium resolution defines the typing at the antigen level (first field). This is in contrast to high-resolution typing, which defines typing at the allele (molecular) level (second field or higher).

Blood

Acd/Yellow

Container/Tube: Yellow top (ACD solution B) Specimen: 6 mL whole Blood ( 3 mL min) Transport Temperature: Room Temperature Instructions: Do not transfer blood to other containers. Additional Information: Specimen acceptability is based on extracted DNA concentration and not sample age

Room Temperature

Polymerase Chain Reaction (PCR)/Sequence-Specific Oligonucleotide Probes (SSO)

Mayo Medical Laboratories Mayo Code 1DIS

81372 (if all loci-A, B, C performed) 81373 (if appropriate for each loci if less than 3 performed) LONIC Code: 96629-1

2059436