HLA B27 Molecular Detection
Test Catalog Information
| Test Catalog Synonyms | |
| EPIC Synonyms |
Ankylosing Spondylitis HLA-B27 Antigen HLX HLA B27 Genotype Case HLA Antigen B27 |
| Cerner Primary Mnemonic | HLX HLA B27 Genotype Case |
| EPIC Display Name | HLA B27 Molecular Detection |
| Allscripts (AEHR) Order Name | HLA B27 Genotyping |
| Sunrise Clinical Manager (SCM) Order Name | HLA B27 Genotyping |
| EPIC Inpatient Orderable | Yes |
| EPIC Outpatient Orderable | Yes |
| Cerner Results | |
| Clinical Info |
Ankylosing spondylitis (AS) is a rheumatic inflammatory disease that belongs to the group of spondyloarthropathies. Human leukocyte antigen B27 (HLA-B27) is strongly associated with AS. There has been an increasing appreciation of HLA-B27 positivity in facilitating the diagnosis of an early stage of AS. About 90% of AS patients are HLA-B27 positive, compared to 5-10% of the general population. In addition, an increased prevalence of HLA-B27 has been reported in patients with Reiter's syndrome, anterior uveitis, psoriatic arthritis, and inflammatory bowel disease. As a result, tests of HLA-B27 are a valuable adjunct in the diagnosis of these diseases. Limitations: This test does not rule out the B*27:06 and 27:09 alleles, which are not associated with spondyloarthropathies. Certain rare alleles present in less than 1 percent of the population will not be detected. Other rare, or uncharacterized alleles may occur which may lead to false positive or false negative results. |
| Specimen Type |
Blood |
| Container |
Lavender Top Tube |
| Collection Instructions |
Container/Tube: Lavender Top EDTA tube Specimen: 1-3 mL peripheral blood Transport Temperature: Room Temperature Specimens should be accompanied by a test request form and a signed consent form stating that the patient agrees to be tested for HLA-B*5701 genotyping. The consent form should be signed by the patient or designee and the health care provider. |
| Transport Instructions |
Room temperature |
| Specimen Stability |
Specimens are stable for a week refrigerated. |
| Methodology |
Real Time Polymerase Chain Reaction (RT-PCR) |
| Days Performed |
Monday through Friday TAT: 8 Calendar days |
| Performing Laboratory |
Northwell Health Laboratories |
| CPT |
81374 |
| PDM |
238466 |
Desired Epic Build HLA B27 Molecular Detection
| Cerner Primary Mnemonic: | HLX HLA B27 Genotype Case |
| PDM | 238466 |
| Informatics - Workgroup | Molpath inhouse |
| Synonyms * | Ankylosing Spondylitis HLA-B27 Antigen HLX HLA B27 Genotype Case HLA Antigen B27 |
| Display Name * | HLA B27 Molecular Detection |
| Order Entry Specimen Sources * | |
| Order Entry Specimen Types |
Blood
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| Specimen Navigator Specimen Types | |
| Specimen Navigator Specimen Sources | |
| Specimen Navigator Short Name | |
| Ordering info (EPIC SmartText) | Ankylosing spondylitis (AS) is a rheumatic inflammatory disease that belongs to the group of spondyloarthropathies. Human leukocyte antigen B27 (HLA-B27) is strongly associated with AS. There has been an increasing appreciation of HLA-B27 positivity in facilitating the diagnosis of an early stage of AS. About 90% of AS patients are HLA-B27 positive, compared to 5-10% of the general population. In addition, an increased prevalence of HLA-B27 has been reported in patients with Reiter's syndrome, anterior uveitis, psoriatic arthritis, and inflammatory bowel disease. As a result, tests of HLA-B27 are a valuable adjunct in the diagnosis of these diseases. Limitations: This test does not rule out the B*27:06 and 27:09 alleles, which are not associated with spondyloarthropathies. Certain rare alleles present in less than 1 percent of the population will not be detected. Other rare, or uncharacterized alleles may occur which may lead to false positive or false negative results. |
| IP Orderable | Yes |
| OP Orderable | Yes |
|
AOEs * | |
| AP AOEs | |
| Special History | No |
| Build Comments | |
| Filter * | genetics |
| Procedure Category Change | |
| Cerner Results | |
Current Actual EPIC Build as of 10/28/2024
| Procedure Id | 115145 | ||||||||||||||||||||||||
| Pdm | 238466 | ||||||||||||||||||||||||
| Order Display Name | HLA B27 Molecular Detection | ||||||||||||||||||||||||
| Procedure Name | HLA B27 GENOTYPING | ||||||||||||||||||||||||
| Procedure Master Number | LAB11402 | ||||||||||||||||||||||||
| Short Procedure Name | HLA B27 GENOTYPING | ||||||||||||||||||||||||
| Category Code | 21.0 | ||||||||||||||||||||||||
| Category Code Record Name | LAB MOLECULAR DIAGNOSTICS ORDERABLES | ||||||||||||||||||||||||
| Synonyms | ANKYLOSING SPONDYLITIS HLA-B27 ANTIGEN HLX HLA B27 GENOTYPE CASE HLA ANTIGEN B27 | ||||||||||||||||||||||||
| Clinically Active | Yes | ||||||||||||||||||||||||
| Orderable | Yes | ||||||||||||||||||||||||
| Performable | Yes | ||||||||||||||||||||||||
| Filter Genomics | Generic Genomics Procedure | ||||||||||||||||||||||||
| Reference Link Url | https://labs.northwell.edu/epic/test/115145 | ||||||||||||||||||||||||
| Ordering Instructions |
Ankylosing spondylitis (AS) is a rheumatic inflammatory disease that belongs to the group of spondyloarthropathies. Human leukocyte antigen B27 (HLA-B27) is strongly associated with AS. There has been an increasing appreciati
on of HLA-B27 positivity in facilitating the diagnosis of an early stage of AS. About 90% of AS patients are HLA-B27 positive, compared to 5-10% of the general population. In addition, an increased prevalence of HLA-B27 has b
een reported in patients with Reiter's syndrome, anterior uveitis, psoriatic arthritis, and inflammatory bowel disease. As a result, tests of HLA-B27 are a valuable adjunct in the diagnosis of these diseases.
Limitations: This test does not rule out the B*27:06 and 27:09 alleles, which are not associated with spondyloarthropathies. Certain rare alleles present in less than 1 percent of the population will not be detected. Other ra re, or uncharacterized alleles may occur which may lead to false positive or false negative results. |
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| Default Specimen Type | Blood | ||||||||||||||||||||||||
| Specimen Type Pick List | Blood | ||||||||||||||||||||||||
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| Specimen Source Pick List | Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous | ||||||||||||||||||||||||
| Specimen Source Default - Male | Blood, Venous | ||||||||||||||||||||||||
| Specimen Source Default - Female | Blood, Venous | ||||||||||||||||||||||||
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| Ip Lab Test Components For Report | HLXB27 | ||||||||||||||||||||||||
| Op Lab Test Components For Report | HLXB27 | ||||||||||||||||||||||||
| Order Questions | ["3045300170", "3045300171", "3045300173"] | ||||||||||||||||||||||||
| Order Questions Record Name | NH IP HOME COLLECT DATE NH IP HOME COLLECT DAYS NH IP HOME COLLECT MEDICALLY NECESSARY | ||||||||||||||||||||||||
| Inpatient Order Questions | ["3048500000"] | ||||||||||||||||||||||||
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| Order Specific Question Override | Yes | ||||||||||||||||||||||||
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| Edp Amb Order Specific Questions Record Name | NH IP PATIENT COMPLETED CONSENT | ||||||||||||||||||||||||
| Edp Ip Order Specific Questions Record Name | NH IP PATIENT COMPLETED CONSENT | ||||||||||||||||||||||||
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| Ip Orderable | 1 | ||||||||||||||||||||||||
| Op Orderable | 1 | ||||||||||||||||||||||||
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