Inpatient and Outpatient Orderable

24 Hour Urine, 5-Hydroxyindoleacetic Acid (5-HIAA), Quantitative

Synonyms

  • 5 HIAA, URINE, QUANTITATIVE, 24 HOUR
  • 5HIAA W/CREATININE 24 HR UR
  • HYDROXYINDOLEACETIC ACID 24 HR
  • LAB352

Cerner Name

5HIAA w/Creatinine 24 hr UR

Clinical Info

5-HIAA is the end product of serotonin (5-hydroxytryptophan) and tyrptophan metabolism. Patients with carcinoid tumors of the midgut, e.g., ileum, produce high concentrations of 5-HIAA. Patients with carcinoid tumors of the foregut and hindgut may produce little or no 5-HIAA or do so intermittently..

Specimen Sources

Urine, Catheter Urine, Clean Catch

Specimen Types

Urine

Specimen Volume

Container

24hr Ur 25mL 6N HCl

Collection Instructions

Container/Tube: 24 hours urine container
Specimen:10 mL aliquot of a 24-hour urine collected with 25 mL of 6N HCl (5 mL min) please
indicate TV on cup
Urine without preservative is acceptable if pH is below 6.
Transport Temperature: Refrigerated
Stability: 7 Days Room Temperature
30 Days Refrigerated
Collection Instructions
Collect 24-hour urine with 25 mL 6N HCl to maintain a pH ≤ 3. If no preservative is used, specimen must be stored refrigerated during collection but shipped frozen and pH must be > 6.

Transport Instructions

Refrigerated

Specimen Stability

7 Days Room Temperature
               30 Days Refrigerated
 
 Keep urine refrigerated during collection if preservative is not used. Record 24-hour urine volume on t

Methodology

High Performance Liquid Chromatography (HPLC) • Electrochemical Detection

Days Performed

TAT: 2-5 Days

Performing Laboratory

Quest Diagnostics' Nichols Institute, Inc. - Chantilly

CPT

82570
83497

PDM

5901716

Only Orderable at Locations:

Orderable Everywhere

Results
Component Name Base Name Common Name External Name
5-HIAA, 24-HOUR URINE 5HYDROXY 5 HIAA 24H UR 5-HIAA, 24 Hour Urine
CREATININE, 24-HOUR URINE CREAT24HRUR CREATININE 24H UR Creatinine, 24-Hour Urine
TOTAL VOLUME URINETOTALV URINE TOTAL VOLUME Total Volume

Result Interpretation

2-10 years: 8.0 mg/24 hr or less
>10 years: 6.0 mg/24 hr or less
 
Limitations: Patients with renal disease may display falsely decreased results. Urinary 5-HIAA is increased in patients with malabsorption disorders who also display a larger concentration of urinary tryptophan metabolites. Urinary 5-HIAA is increased in patients with intestinal obstruction and with some noncarcinoid islet cell tumors. Carcinoid syndrome may not cause elevated results, especially if the patient does not have diarrhea. Requires accurate 24-hour urine collection.

Forms
LAB352 build edit