Random Urine, Vanillylmandelic Acid (VMA) and Homovanillic Acid (HVA)

Synonyms

  • LAB11061
  • RANDOM URINE, VANILLYLMANDELIC ACID (VMA) AND HOMOVANILLIC ACID (HVA)
  • VMA AND HVA, CHILD
  • VMAHVA

Cerner Name

VMA and HVA, Child

Clinical Info

First preferred test for screening for catecholamine-secreting tumors in a random urine specimen when requesting both homovanillic acid and vanillylmandelic acid
Supporting a diagnosis of neuroblastoma
Monitoring patients with a treated neuroblastoma

Specimen Sources

Bladder Kidney, Left Kidney, Right Ureter, Left Ureter, Right Urine, Catheter Urine, Clean Catch

Specimen Types

Urine

Specimen Volume

Container

Urine Cntr

Collection Instructions

Container/Tube: Sterile cup
Volume: 5 mL random urine (2 mL min)
Collection Instructions:
1. Collect a random urine specimen.
2. Adjust urine pH to 1 to 5 with 50% acetic or hydrochloric
acid.
Patient Preparation: Administration of L-dopa may falsely
increase homovanillic acid and vanillylmandelic acid results; it
should be discontinued 24 hours prior to and during collection of
specimen.

Transport Instructions

Refrigerated

Specimen Stability

28 days Refrigerated
180 Days Frozen

Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Days Performed

TAT: 4-6 Days

Performing Laboratories

Mayo Medical Laboratories

CPT

83150-HVA
84585-VMA
LOINC Code: 90250-2

PDM

5908565

Results
Component Name Base Name Common Name External Name
VANILLYLMANDELIC ACID, CHILD VANCH VANILLYLMANDELIC ACID, CHILD Vanillylmandelic Acid
HOMOVANILLIC ACID, CHILD HVAC HOMOVANILLIC ACID CHILD Homovanillic Acid
VMAHVA CD VMAHVA VMAHVA CD VMAHVA Collection Duration
VMAHVA VOL VMAHVA VMAHVA VOL VMAHVA Volume

Result Interpretation

VANILLYLMANDELIC ACID

<1 year: <25.0 mg/g creatinine

1 year: <22.5 mg/g creatinine

2-4 years: <16.0 mg/g creatinine

5-9 years: <12.0 mg/g creatinine

10-14 years: <8.0 mg/g creatinine

> or =15 years: <7.0 mg/g creatinine

 

HOMOVANILIC ACID

<1 year: <35.0 mg/g creatinine

1 year: <30.0 mg/g creatinine

2-4 years: <25.0 mg/g creatinine

5-9 years: <15.0 mg/g creatinine

10-14 years: <9.0 mg/g creatinine

> or =15 years: <8.0 mg/g creatinine

Forms
Endocrine LAB11061 build edit