CSF, ADmark Phospho-Tau/Total-Tau/A Beta42, Analysis and Interpretation (Symptomatic)

Synonyms

  • CSF, ADMARK PHOSPHO-TAU/TOTAL-TAU/A BETA42,ANALYSIS AND INTERPRETATION (SYMPTOMATIC)
  • LAB11024
  • TAUCSF

Cerner Name

ADmark Phospho-Tau/Total-TA

Clinical Info

Admark® Alzheimer's Evaluation, CSF (FDA Cleared) - Elecsys Beta Amyloid (1 42) CSF II, Phospho-Tau (181P) CSF and Elecsys Total Tau CSF are in vitro electrochemiluminescence immunoassays for the measurement of the Beta Amyloid (1 42) (Abeta42), PTau (181P) and Total Tau (tTau) protein concentration in cerebrospinal fluid (CSF) from adult patients aged 55 years and older being evaluated for Alzheimer's disease (AD) and other causes of cognitive impairment to generate a tTau/Abeta42 and pTau-181/Abeta42 ratios and values. A negative result, defined as tTau/Abeta42 and Phospho-Tau (181P) ratio values below cutoff or an Abeta42 value above the measuring range, are consistent with a negative amyloid positron emission tomography (PET) scan result. A negative result reduces the likelihood that a patient?s cognitive impairment is due to AD. A positive result, defined as tTau/Abeta42 and pTau181/Abeta42 ratio value above cutoff, is consistent with a positive amyloid PET scan result. A positive result does not establish a diagnosis of AD or other cognitive disorder. The tTau/Abeta42 and pTau181/Abeta42 ratio results are used as an adjunct to other clinical diagnostic evaluations.

Specimen Sources

CSF Reservoir Lumbar Puncture VP Shunt Aspirate

Specimen Types

Cerebrospinal Fluid

Specimen Volume

1 mL CSF ( 0.7 mL min)

Container

Sarstedt CSF Low protein-binding polypropylene Tube (Order number: 63.614.625)

Collection Instructions

Do not process the CSF sample before transport to the measuring site (i.e., no mixing/inverting, no tube transfers, no aliquoting, no freezing and normally no centrifugation) until measurement.
Specimen Reject Criteria:
1: CSF samples collected in non-polypropylene tubes
2: CSF specimens with gross hemolysis

Transport Instructions

Refrigerated

Specimen Stability

Room temperature: 5 days
Refrigerated: 14 days
Frozen: 56 days

Methodology

Electrochemiluminescence (ECLIA)

Days Performed

TAT: 3-5 Days

Performing Laboratories

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

CPT

84393
82234
84394

PDM

2159034

Results
Component Name Base Name Common Name External Name
ADMARK PHOSPHO-TAU/TOTAL-TA ADMARKPHOSTA ADMARK PHOSPHO TAU TOTAL TA ADmark Phospho-Tau/Total-TA
SUMMARY INTERPRETATION TAUCSF1 SUMMARY INTERPRETATION Summary Interpretation
BETA-AMYLOID (1-42) CSF TAUCSF2 BETA-AMYLOID (1-42) CSF Beta-Amyloid (1-42),CSF
TTAU,CSF TAUCSF3 TTAU,CSF tTau,CSF
PTAU181 CSF TAUCSF5 PTAU181 CSF pTau181,CSF
TTAU ABETA42 RATIO TAUCSF5 TTAU ABETA42 RATIO tTau/Abeta42 Ratio
TTAU ABETA42 INTERP TAUCSF6 TTAU ABETA42 INTERP tTau/Abeta42 Interp
PTAU181 ABETA 42 RATIO TAUCSF7 PTAU181 ABETA 42 RATIO pTau181/Abeta42 Ratio
PTAU181 ABETA42 INTERP TAUCSF8 PTAU181 ABETA42 INTERP pTau181/Abeta42 Interp
COMMENTS(TAU,CSF) TAUCSF9 COMMENTS(TAU,CSF) Comments (Tau,CSF)

Result Interpretation

See report

Forms
Chemistry LAB11024 build edit