Inpatient and Outpatient Orderable

Beta-Amyloid 42/40 Ratio

Synonyms

  • ABETA42/40
  • BETA-AMYLOID 42/40 RATIO
  • BETAAMYOID
  • LAB14288

Cerner Name

Beta-Amyloid 42/40 Ratio

Clinical Info

This LC-MS/MS assay measures beta-amyloid 40 (AB40) as well as AB42 in plasma, rather than AB42 alone. This permits the normalization of beta amyloid levels circulating in plasma in different patients. Using the ratio of beta-amyloid 42/beta-amyloid 40, improves sensitivity and specificity for detecting Alzheimer's disease.

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

1.2 mL plasma (0.6 mL min)

Container

Lavender Top Tube

Collection Instructions

Container/Tube:  Lavender Top Tube
Specimen; 1.2 mL plasma  (0.6 mL min)
Collection Instructions; Spin and separate plasma from cells within one hour of collection.

Transport Instructions

Frozen

Specimen Stability

Unacceptable  Room Temperature
3 Days Refrigerated
32 Days Frozen

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Days Performed

TAT: 5-7 Days

Performing Laboratory

Quest Diagnostics Nichols Institute San Juan Capistrano CA

CPT

82233
82234

PDM

245767

Only Orderable at Locations:

Orderable Everywhere

Results
Component Name Base Name Common Name External Name
ABETA 42 ABETA ABETA 42 ABeta 42
ABETA 40 ABETA ABETA 40 ABeta 40
ABETA 42/40 RATIO ABETA ABETA 42/40 RATIO ABeta 42/40 Ratio

Result Interpretation

ABeta 42 Not established pg/mL
ABeta 40 Not established pg/mL
ABeta 42/40 Ratio ≥0.170

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Forms
LAB14288 build edit