Inpatient and Outpatient Orderable

Lyme Antibodies - Central Nervous System Infection with Reflex to Index, Serum and CSF (Paired)

Synonyms

  • LAB12059
  • LYME DISEASE AB PAIR INDEX REFLEX
  • Lyme Disease AB Pair Index Reflex
  • LYMEPAIR

Cerner Name

Lyme Disease AB Pair Index Reflex

Clinical Info

Aiding in the diagnosis of neuroinvasive Lyme disease or neuroborreliosis due to Borrelia species associated 
with Lyme disease (eg, Borrelia burgdorferi, Borrelia garinii, Borrelia afzelli)
Requires CSF and Serum

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous CSF Reservoir Cerebrospinal Fluid, Ventricular Lumbar Puncture

Specimen Types

Blood Cerebrospinal Fluid

Specimen Volume

1.2 mL CSF and 1.2 mL Serum

Container

CSF Tube

Collection Instructions

Both spinal fluid (CSF) and serum are required for this test. CSF and serum must be collected
within 24 hours (maximum) of each other.
Container/Tube: Sterile Vial (CSF) Gold Top tube (serum)
Specimen: 1.2 mL CSF and 1.2 mL serum
Transport Temperature: Refrigerated

Transport Instructions

Refrigerated

Specimen Stability

CSF 11 days Refrigerated
35 days Frozen
Serum 11 days Refrigerated
35 days Frozen

Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)
Testing Algorithm:
This test begins with IgG screening of the spinal fluid specimen. If the screen is negative, no additional 
testing will be performed.
If the screen is positive, the paired CSF and serum specimens will be used to establish the antibody index. 
In order to establish the antibody index, the paired serum and CSF samples (collected within 24 hours of 
each other) are tested on the same run using quantitative assays to determine levels for the following analytes:
1. Anti-Borrelia species IgG levels in CSF and serum
2. Total IgG in CSF and serum
3. Albumin in CSF and serum
These additional tests are necessary in order to normalize the level of anti-Borrelia antibodies to total IgG 
and albumin in the CSF and establish the antibody index ratio of anti-Borrelia antibodies in CSF-to-serum. 
This testing is performed at an additional charge.

Days Performed

TAT: 2-5 Days

Performing Laboratory

Mayo Medical Laboratories

CPT

86618
86618 x2 - if applicable
82040 - if applicable
82042- if applicable
82784 x2 - if applicable
LOINC Code: 92815-0

PDM

235308

Only Orderable at Locations:

Orderable Everywhere

Results
Component Name Base Name Common Name External Name
LYME CNS INFECTION IGG, CSF LYMECNSCSF LYME CNS INFECTION IGG CSF Lyme CNS Infection IgG CSF
LYME CNS INFECTION IGG INTERP LYMECNSINT LYME CNS INFECTION IGG INTERP Lyme CNS Infection IgG Interpretation
LYME CNS INFECTION IGG, SERUM LYMECNSIGG LYME CNS INFECTION IGG SERUM Lyme CNS Infection IgG Serum

Result Interpretation

Negative

Forms
LAB12059 build edit