Lyme Disease AB Pair Index Reflex, Serum and CSF

Lyme Disease AB Pair Index with Reflex

Aiding in the diagnosis of neuroinvasive Lyme disease or neuroborreliosis due to Borrelia species associated  with Lyme disease (eg, Borrelia burgdorferi, Borrelia garinii, Borrelia afzelli) Requires CSF and Serum

Blood, CSF

CSF Tube

Both spinal fluid (CSF) and serum are required for this test. CSF and serum must be collected within 24 hours (maximum) of each other. Container/Tube: Sterile Vial (CSF) Gold Top tube (serum) Specimen: 1.2 mL CSF and 1.2 mL serum Transport Temperature: Refrigerated

Refrigerated

CSF 11 days Refrigerated 35 days Frozen Serum 11 days Refrigerated 35 days Frozen

Enzyme-Linked Immunosorbent Assay (ELISA) Testing Algorithm: This test begins with IgG screening of the spinal fluid specimen. If the screen is negative, no additional  testing will be performed. If the screen is positive, the paired CSF and serum specimens will be used to establish the antibody index.  In order to establish the antibody index, the paired serum and CSF samples (collected within 24 hours of  each other) are tested on the same run using quantitative assays to determine levels for the following analytes: 1. Anti-Borrelia species IgG levels in CSF and serum 2. Total IgG in CSF and serum 3. Albumin in CSF and serum These additional tests are necessary in order to normalize the level of anti-Borrelia antibodies to total IgG  and albumin in the CSF and establish the antibody index ratio of anti-Borrelia antibodies in CSF-to-serum.  This testing is performed at an additional charge.

TAT: 2-5 Days

Mayo Medical Laboratories

86618 86618 x2 - if applicable 82040 - if applicable 82042- if applicable 82784 x2 - if applicable LOINC Code: 92815-0

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