Creatine Kinase (CK), Total Plus Isoenzymes

Synonyms

• CK ISOENZYMES
• CKI
• CPK ISOENZYMES ELECTROPHORESIS
• CREATINE PHOSPHOKINASE
• LAB64

Cerner Name

Creatine Kinase (CK), Total Plus Isoenzymes

Clinical Info

High sensitivity Troponin testing is recommended for diagnosis and management of acute coronary syndrome including myocardial infarction (MI).
This test includes Total CK and relative percentage of BB (CK-1), MB (CK-2), and MM (CK-3); percentage of macro CK, if present.
Creatine Kinase Isoenzymes may aid in determining the etiology of elevated total creatine kinase.

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

2 mL serum ( 1.5 mL min)

Container

Gold Top Tube

Collection Instructions

Patient Preparation:
Collection of specimens at onset of symptoms to establish baseline values is needed. A patient at onset of AMI will have normal results, but some patients reach medical attention at or beyond CK peak. To support the diagnosis of AMI, three CK isoenzyme determinations have classically been recommended, one on admission, a second 12 hours after admission, a third 24 hours after admission. Another at 48 hours may be needed. CK-MB usually peaks between 15 and 20 hours after the onset of a myocardial infarction.
Causes for Rejection:
Moderate or excessive hemolysis

Transport Instructions

Frozen serum in plastic vial.

Specimen Stability

Refrigerate up to 48 hours.
Freeze (-20°C) up to two weeks

Methodology

Total: kinetic
Isoenzymes: agarose gel electrophoresis with densitometry

Days Performed

TAT: 4 to 7 Days

Performing Laboratories

LabCorp Burlington

CPT

82550 - CPK
82552 - isoenzymes

PDM

5300175

Results

Result Interpretation

Forms