C4B Binding Protein

Synonyms

  • C4B BINDING PROTEIN
  • C4BP
  • LAB11074

Cerner Name

C4B Binding Protein

Clinical Info

Confirmation and characterization of protein S (PS) deficiency: C4b-binding protein elevates as an acute phase protein that may lead to enhanced protein S binding and decreased free protein S levels.

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

1 mL plasma (0.5mL min)

Container

ESR

Collection Instructions

Container/Tube:  Light blue-top (3.2% sodium citrate) tube
Specimen:   1 mL plasma (0.5mL min)
 
Collection: Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples, except when using a winged blood collection device (ie, "butterfly"), in which case a discard tube should be used. When non citrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. Deliver to a plastic transport tube, cap, and recentrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube.

Transport Instructions

Frozen plasma

Specimen Stability

8 Hours Room Temperature
14 Days Frozen

Methodology

Enzyme-linked immunosorbent assay (ELISA)

Days Performed

TAT: 5-9 Days

Performing Laboratories

Esoterix Endocrinology

CPT

83520

PDM

5601085

Results
Component Name Base Name Common Name External Name
C4B BINDING PROTEIN C4B C4B BINDING PROTEIN C4B Binding Protein

Result Interpretation

60 - 130 %
Adult levels of C4bBP are generally reached at six months of age. Levels are generally undetectable in the neonate.
 
 
Turnaround time: 2 - 7 days

Forms
Hematology LAB11074 build edit