Thiopurine Metabolites Build info

Synonyms

• THIOPURINE METABOLITES
• 6MP
• LAB10027

Short Name

THIOPURINE METABOLITES

Procedure Master Number

LAB10027

Procedure ID

169871

Clinical Info

This assay measures the red-cell concentration of 6-MMP (formed from 6-MP by thiopurine methyltransferase) and also measures the concentration of the resulting 6-TG after removal of the mono-, di-, or tri-phosphates from the various 6-thioguanine nucleotides.

Specimen Type

Blood

Container

Lavender Top Tube

Collection Instructions

Container/Tube: EDTA Lavender top tube
Specimen: 3 mL EDTA whole blood (1 mL min)
Transport Temperature: Refrigerate
Stability: 14 Days Refrigerated
                Unstable Frozen
Note: Send specimen within14 days of collection.

Transport Instructions

Refrigerate

Specimen Stability

14 Days Refrigerated
                Unstable Frozen
Note: Send specimen within14 days of collection.

Methodology

Whole blood washing and red blood cell harvesting/counting. Liquid chromatography/tandem mass spectrometry (LC/MS-MS) after acidic hydrolysis.

Days Performed

TAT: 7-13 Days
Limitations
This test should only be performed for patients currently on thiopurine therapy. This therapy includes administration of azathioprine or mercaptopurine. This test may not be useful in patients with autoimmune hepatitis.

Performing Laboratory

LabCorp of America

CPT

80375
LOINC Code: 82869-9

PDM

5911041

Results