Felbamate Level

Synonyms

  • AED
  • ANTI-CONVULSANT
  • ANTI-EPILEPTIC
  • ANTICONVULSANT
  • ANTIEPILEPTIC
  • DRUG
  • FELBAMATE LEVEL
  • FELBATOL
  • LAB686

Cerner Name

Felbamate

Clinical Info

Evaluate toxicity; monitor therapeutic levels

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

2 mL serum ( 0.6 mL min)

Container

Red Top Tube

Collection Instructions

Container/Tube: Red Top Tube (Gold not acceptable)
Specimen: 2 mL serum ( 0.6 mL min)

Transport Instructions

Refrigerated

Specimen Stability

14 Days Room Temperature, Refrigerated or Frozen

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Days Performed

TAT: 3- 5 Days

Performing Laboratories

LabCorp

CPT

80167
 
LOINC Code: 6899-9
 
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

PDM

5900620

Results
Component Name Base Name Common Name External Name
FELBAMATE FELBAMATE FELBAMATE Felbamate

Result Interpretation

Therapeutic: 25−104 μg/mL; steady-state trough levels are dose proportional in adults. Multiple daily doses of 1200, 2400, and 3600 mg/day gave trough levels of 25−35, 47−63, and 62−104 μg/mL, respectively. Steady-state peak concentrations are dose proportional in children ages 4 to 12 years over a range of 15, 30, 45 mg/kg/day. The dose proportional peak concentrations were reported as 17, 32, and 49 μg/mL, respectively at two to six hours postdose. Co-administration of carbamazepine, phenytoin, phenobarbital, or primidone can cause a decrease in felbamate plasma concentrations; conversely, valproic acid can increase concentrations.1 In children, a similar effect was found with carbamazepine and phenytoin decreasing levels and an opposite effect with valproic acid.2
1. Bourgeois BF. Pharmacokinetic properties of current antiepileptic drugs: What improvements are needed? Neurology. 2000; 55(Suppl 3):S11-S16. PubMed 11147563
2. Kelley MT, Walson PD, Cox S, Dusci LJ. Population pharmacokinetics of felbamate in children. Ther Drug Monit. 1997 Feb; 19(1):29-36. PubMed 9029743

Forms
Tox/TDM LAB686 build edit