Inpatient and Outpatient Orderable

T Cell Gene Rearrangement (TCR) Molecular Detection Build info

Synonyms

  • MOLECULAR GENETICS - TCR
  • MG TCR
  • TCRG
  • T CELL GAMMA
  • T-CELL RECEPTOR GAMMA REARRANGEMENT
  • HLX TCR BY PCR CASE
  • LAB11405

Short Name

T Cell Rearrangement

Procedure Master Number

LAB11405

Procedure ID

115151

Clinical Info

Leukemias and lymphomas are characterized by the presence of clonal B-or T-cell populations. Rearrangement of the antigen receptor genes occur during the ontogeny of B and T cell lymphocytes. The rearrangements are unique in length and sequence for each cell. The T-cell receptor genes in T-cells are composed of 4 different chains α, β, γ and δ. Each one is the product of rearrangement of the Variable, Diversity, Constant and Joining regions of the respective genes. Each B- and T-cell has a single productive V-J rearrangement that is unique in both length and sequence. 

Specimen Sources

 Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous Bone Marrow

Specimen Types

 Aspirate Blood

Container

Lavender Top Tube

Collection Instructions

Container/Tube: Lavender Top Tube or Sterile Container
Specimen: 1-3 mL of Peripheral Blood or Bone Marrow Aspirate collected in lavender top (EDTA) tube, transport at room temperature or 4°C.
Pleural Fluid (thoracentesis fluid) and fine needle aspirate (FNA) specimens collected in a sterile tube, transport at 4°C, submit at least 0.5 x 10^7 cells.
Formalin fixed paraffin embedded(FFPE) tissue, specimens should be representative of the tumor (contain neoplastic cells) as determined per pathologist.
5-10 Sections, 10 um thick. FFPE tissue can be stored indefinitely at room temperature.
Transport Temperature: Blood or Bone marrow: Room temperature or Refrigerated. Do Not Freeze.        FFPE: Room temperature, FNA and Pleural Fluid: Refrigerated

Transport Instructions

room temperature or 4°C

Specimen Stability

Blood or Bone marrow; 7 Days Refrigerated. Do Not Freeze
FFPE Indefinitely at room temperature
FNA and Pleural Fluid 7 Days Refrigerated

Methodology

Multiplex Polymerase Chain Reaction (PCR) Amplification followed by Capillary Electrophoresis Analysis

Days Performed

Monday through Friday
TAT: 8 Calendar days

Performing Laboratory

Northwell Health Laboratories

CPT

81342

PDM

 5160176

Only Orderable at Locations:

 Orderable Everywhere

Results