Phosphatidylserine Antibodies (IgA, IgG, IgM)

Synonyms

  • LAB1180
  • PHOSPHATIDYLSERINE ANTIBODIES

Cerner Name

Phosphatidyl Serine Antibodies

Clinical Info

Not a recommended panel for the diagnosis of antiphospholipid syndrome (APS). The combined IgG and IgM Phosphatidylserine test is the preferred second-line testing in seronegative APS.

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

0.5 mL serum (Min: 0.25 mL)

Container

Gold Top Tube

Collection Instructions

Container/Tube:  Gold-top tube
Specimen: 0.5 mL serum (Min: 0.25 mL)
Transport Temperature:  Refrigerate

Transport Instructions

Refrigerate

Specimen Stability


Room Temperature: 2 Days
Refrigerated: 2 weeks 
Frozen: 1 month

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Days Performed

TAT: 2-7 Days

Performing Laboratories

ARUP Laboratory

CPT

86148 x 3

PDM

5909092

Results
Component Name Base Name Common Name External Name
PHOSPHATIDYL SERINE ANTIBODY IGM PHOSPHSERIGM PHOSPHATIDYL SERINE ANTIBODY IGM Antiphosphatidylserine IgM
PHOSPHATIDYL SERINE ANTIBODY IGA PHOSPHSERIGA PHOSPHATIDYL SERINE ANTIBODY IGA Antiphosphatidylserine IgA
PHOSPHATIDYL SERINE ANTIBODY IGG PHOSPHSERIGG PHOSPHATIDYL SERINE ANTIBODY IGG Antiphosphatidylserine IgG

Result Interpretation

 

Interpretive Data
IgG and/or IgM antibodies to phosphatidylserine (aPS) may be associated with a positive test for anti-cardiolipin autoantibodies (aCL) and risk for obstetric antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies.

Isolated presence of IgM or IgG antibodies to aPS may have questionable clinical significance for APS and/or SLE.

If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.

Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.

 

Forms
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Workgroup: Immunology
Procedure Master Number: LAB1180
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