Inpatient and Outpatient Orderable

Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG CBA-IFA with Reflex to Titer, Serum Build info

Synonyms

  • LGI1 AB IGG BY CBA-IFA W/RFLX TO TITER
  • LGI1AB
  • LGI1 AB IGG CBA-IFA WITH REFELX TO TITER
  • LAB11055

Procedure Name

LGI1 AB IGG BY CBA-IFA W/RFLX TO TITER

Procedure Master Number

LAB11055

Procedure ID

114514

Clinical Info

Aid in diagnosis of leucine-rich glioma inactivated 1 protein (LGI1) antibody disorders associated with limbic encephalitis, hyponatremia, and myoclonic movements. 
Disorders are rarely associated with tumors. Use to manage antibody-positive (LGI1) individual following immunotherapy and/or plasmapheresis
 
Leucine-rich, glioma-inactivated 1 protein (LGI1) IgG antibody may occur as part of the voltage-gated potassium channel (VGKC) complex antibodies. 
 The presence of LGI1 IgG antibody is mainly associated with limbic encephalitis, hyponatremia and myoclonic movements. LGI1 IgG antibody is rarely 
associated with tumors but may occur infrequently in Morvan syndrome, neuromyotonia and idiopathic epilepsy. The full-spectrum of clinical disorders 
associated with the LGI1 IgG antibody continues to be defined. Results should be interpreted in correlation with the patient's clinical history and other 
laboratory findings. This indirect fluorescent antibody assay utilizes leucine-rich, glioma-inactivated 1 protein (LGI1) transfected cell lines for the detection 
and semi-quantification of the LGI1 IgG antibody.  

Specimen Sources

 Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

 Blood

Container

Gold Top Tube

Collection Instructions

Container/Tube: Gold top tube
Specimen: 1 mL serum ( 0.2 mL min)
Transport Temperature: Refrigerated
Note: Separate serum from cells within 2 hours of collection

Specimen Volume

1 mL serum ( 0.2 mL min) Separate serum from cells within 2 hours of collection

Transport Instructions

Refrigerated

Specimen Stability

2 Days Room Temperature
14 Days Refrigerated
Year Frozen

Methodology

Semi-Quantitative Indirect Fluorescent Antibody

Days Performed

TAT: 2-9 Days

Performing Laboratory

ARUP Laboratories

CPT

86255
Reflex titer  86256
 
LOINC Code:  82978-8

PDM

 1859768

Only Orderable at Locations:

 Orderable Everywhere

Results
Component Name Base Name Common Name External Name
LGI1 AB IGG SCREEN BY IFA LG1ABIGGSC LGI1 AB IGG SCREEN BY IFA LGI1 Ab IgG Screen by IFA
LGI1 AB IGG TITER BY IFA LG1ABIGGT LGI1 AB IGG TITER BY IFA LGI1 Ab IgG Titer by IFA

Result Interpretation

Less than 1:10
If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. Additional charges apply
 

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