Inpatient and Outpatient Orderable
Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG CBA-IFA with Reflex to Titer, Serum
Synonyms
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- LAB11055
- LGI1 AB IGG CBA-IFA WITH REFELX TO TITER
- LGI1 AB IGG BY CBA-IFA W/RFLX TO TITER
- LGI1AB
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Cerner Name
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LGI1 Ab IGG CBA-IFA with Refelx to Titer
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Clinical Info
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Aid in diagnosis of leucine-rich glioma inactivated 1 protein (LGI1) antibody disorders associated with limbic encephalitis, hyponatremia, and myoclonic movements.
Disorders are rarely associated with tumors. Use to manage antibody-positive (LGI1) individual following immunotherapy and/or plasmapheresis
Leucine-rich, glioma-inactivated 1 protein (LGI1) IgG antibody may occur as part of the voltage-gated potassium channel (VGKC) complex antibodies.
The presence of LGI1 IgG antibody is mainly associated with limbic encephalitis, hyponatremia and myoclonic movements. LGI1 IgG antibody is rarely
associated with tumors but may occur infrequently in Morvan syndrome, neuromyotonia and idiopathic epilepsy. The full-spectrum of clinical disorders
associated with the LGI1 IgG antibody continues to be defined. Results should be interpreted in correlation with the patient's clinical history and other
laboratory findings. This indirect fluorescent antibody assay utilizes leucine-rich, glioma-inactivated 1 protein (LGI1) transfected cell lines for the detection
and semi-quantification of the LGI1 IgG antibody.
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Specimen Sources
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Blood, Arterial
Blood, Capillary
Blood, Central Line
Blood, Venous
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Specimen Types
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Blood
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Container
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Gold Top Tube
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Collection Instructions
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Container/Tube: Gold top tube
Specimen: 1 mL serum ( 0.2 mL min)
Transport Temperature: Refrigerated
Note: Separate serum from cells within 2 hours of collection
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Specimen Volume
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1 mL serum ( 0.2 mL min) Separate serum from cells within 2 hours of collection
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Transport Instructions
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Refrigerated
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Specimen Stability
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2 Days Room Temperature
14 Days Refrigerated
Year Frozen
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Methodology
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Semi-Quantitative Indirect Fluorescent Antibody
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Days Performed
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TAT: 2-9 Days
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Performing Laboratory
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ARUP Laboratories
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CPT
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86255
Reflex titer 86256
LOINC Code: 82978-8
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PDM
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1859768
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Only Orderable at Locations:
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Orderable Everywhere
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Results
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| Component Name |
Base Name |
Common Name |
External Name |
| LGI1 AB IGG SCREEN BY IFA |
LG1ABIGGSC |
LGI1 AB IGG SCREEN BY IFA |
LGI1 Ab IgG Screen by IFA |
| LGI1 AB IGG TITER BY IFA |
LG1ABIGGT |
LGI1 AB IGG TITER BY IFA |
LGI1 Ab IgG Titer by IFA |
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Result Interpretation
Less than 1:10
If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. Additional charges apply
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Forms
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LAB11055
