Random Urine, 2,3-Dinor 11 Beta-Prostaglandin F2 Alpha Build info

Synonyms

  • 2,3-DINOR 11 BETA-PROSTAGLANDIN F2 ALPHA, RANDOM, URINE
  • 2,3-Dinor-11b-Prostaglandin F2a, RU
  • 23BPR
  • LAB11410

Short Name

2,3-DINOR 11 BETA-PROSTAGLANDIN F2 ALPHA, RANDOM, URINE

Procedure Master Number

LAB11410

Procedure ID

NWH_685729557

Clinical Info

Screening for mast cell activation disorders including systemic mastocytosis using random urine specimens
2,3-Dinor-11beta-prostaglandin F2 alpha (2,3 BPG) is the most abundant metabolic product of prostaglandins released by activated mast cells. Systemic mastocytosis (SM) is a disease in which clonally derived mast cells accumulate in peripheral tissues. Degranulation of these mast cells releases large amounts of histamines, prostaglandins, leukotrienes, and tryptase.

World Health Organization diagnostic criteria for SM require the presence of elevated mast cell counts on a bone marrow biopsy and 1 of the following minor criteria: abnormal mast cell morphology, KIT Asp816Val variant, CD25-positive mast cells, or serum tryptase greater than 20 ng/mL. Alternatively, SM diagnosis can be made with the presence of 3 minor criteria in the absence of abnormal bone marrow studies.
Measurement of mast cell mediators in blood or urine is less invasive and is advised for the initial evaluation of suspected cases. Elevated levels of serum tryptase, urinary N-methylhistamine, 2,3 BPG, or leukotriene E4 are consistent with the diagnosis of systemic mast cell disease.

Specimen Type

Urine

Container

Urine Cup

Collection Instructions

Container/Tube: Urine Container
Specimen: 5 mL Random Urine (4 mL min)
Transport Temperature: Refrigerated
Stability: 8 Hours Room Temperature
14 Days Refrigerated
30 Days Frozen

Transport Instructions

Refrigerated

Specimen Stability

8 Hours Room Temperature
14 Days Refrigerated
30 Days Frozen

Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Creatinine: Enzymatic Colorimetric Assay

Days Performed

TAT: 3-7 Days

Performing Laboratory

Mayo Medical Laboratories

CPT

84150
82570
LOINC Code: 97658-9

PDM

2159269, 23BPR

Results

Component Name Base Name Common Name External Name
2,3-DINOR-11B-PROSTAGLANDIN F2A, RANDOM UR 23DINORRU 2, 3 DINOR 11B PROSTAGLANDIN F2A RANDOM UR
CREATININE RANDOM URINE CREATU CREATININE RANDOM URINE Creatinine, Random Ur