Plasminogen Activator Inhibitor

PAI-1 Activity

Plasminogen levels can be decreased in disseminated intravascular coagulation (DIC), hepatitis, leukemia, and with thrombolytic therapy.
 
 

Blood

Blue Top Tube

Container/Tube:  Blue-top (sodium citrate) tube
Specimen: 2 mL citrated plasma (1mL min)
Transport Temperature: Frozen plasma
 
Patient Preparation Ideally, the patient should not be on anticoagulant therapy. Avoid warfarin (Coumadin®) therapy for two weeks prior to the test and heparin, direct Xa, and thrombin inhibitor therapies for about three days prior to testing. Do not draw from an arm with a heparin lock or heparinized catheter.
 
Collection
 
1. Draw blood in a light blue-top (citrate) tube(s). Spin down, remove plasma, spin plasma again, and place 1 mL (minimum volume:  0.3 mL) of citrate platelet-poor plasma in plastic vial. (Glass vial is not acceptable.)
Note:  Double-centrifuged specimens are critical for accurate results as platelet contamination may cause spurious results.
2. Freeze specimen immediately at ?-40° C, if possible.
3. Send specimen frozen.
Note:  Each coagulation assay requested should have its own vial.

Frozen plasma

Streptokinase (SK) as mixed with the patient sample and the resulting plasminogen-SK complex converts a chromogenic substrate to produce color.

Labcorp

85420             

5910017