Plasminogen Activator Inhibitor 1 (PAI-1) Activity Build info

Synonyms

• PAI-1 ACTIVITY
• LAB10973

Short Name

PAI-1 ACTIVITY

Procedure Master Number

LAB10973

Procedure ID

114384

Clinical Info

Plasminogen levels can be decreased in disseminated intravascular coagulation (DIC), hepatitis, leukemia, and with thrombolytic therapy.
 
 

Specimen Type

Blood

Container

Blue Top Tube

Collection Instructions

Container/Tube:  Blue-top (sodium citrate) tube
Specimen: 2 mL citrated plasma (1mL min)
Transport Temperature: Frozen plasma
 
Patient Preparation Ideally, the patient should not be on anticoagulant therapy. Avoid warfarin (Coumadin®) therapy for two weeks prior to the test and heparin, direct Xa, and thrombin inhibitor therapies for about three days prior to testing. Do not draw from an arm with a heparin lock or heparinized catheter.
 
Collection
 
1. Draw blood in a light blue-top (citrate) tube(s). Spin down, remove plasma, spin plasma again, and place 1 mL (minimum volume:  0.3 mL) of citrate platelet-poor plasma in plastic vial. (Glass vial is not acceptable.)
Note:  Double-centrifuged specimens are critical for accurate results as platelet contamination may cause spurious results.
2. Freeze specimen immediately at ?-40° C, if possible.
3. Send specimen frozen.
Note:  Each coagulation assay requested should have its own vial.

Transport Instructions

Frozen plasma

Specimen Stability

Methodology

Streptokinase (SK) as mixed with the patient sample and the resulting plasminogen-SK complex converts a chromogenic substrate to produce color.

Days Performed

Performing Laboratory

Labcorp

CPT

85420             

PDM

5910017

Results