HLA B*15:02, Carbamazepine Sensitivity

Synonyms

  • HLA B*15:2, CARBAMAZEPINE SENSITIVITY
  • HLAB15
  • LAB11148

Cerner Name

HLA B*15:02, Carbamazepine Sensitivity

Clinical Info

Use to identify patients who may be at risk for developing Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) prior to treatment with carbamazepine (CBZ). This test has been recommended for patients of Asian descent who are being considered for carbamazepine therapy. The utility of this test for patients of other ethnic backgrounds has not been established. 

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous Buccal

Specimen Types

Blood Swab

Specimen Volume

7 mL whole blood or 4 buccal swabs

Container

Whole blood or buccal swabs

Collection Instructions

Container/Tube: Collect 7 mL whole blood (2 Lavender Top Tubes) or 4 buccal swabs
Transport Temperature: Maintain whole blood at room temperature or refrigerate. Keep buccal swabs dry and at room temperature

Transport Instructions

Maintain whole blood at room temperature or refrigerate. Keep buccal swabs dry and at room temperature

Specimen Stability

Room Temperature or Refrigerated

Methodology

Sequence-based typing (SBT), sequence-specific oligonucleotide probes (SSOP), and/or sequence-specific primers (SSP) as needed to obtain the required resolution.

Days Performed

TAT: 4-8 Days

Performing Laboratories

LabCorp

CPT

81381

PDM

225706

Results
Component Name Base Name Common Name External Name
HLA-B CARBAMAZEPINE SENSITIVITY ALLELE 1 HLABCARALL1 HLA B CARBAMAZEPINE SENSITIVITY ALLELE 1 HLA-B Carbamazepine Sensitivity Allele 1
HLA-B CARBAMAZEPINE SENSITIVITY ALLELE 2 HLABCARALL2 HLA B CARBAMAZEPINE SENSITIVITY ALLELE 2 HLA-B Carbamazepine Sensitivity Allele 2
HLA METHODOLOGY HLAMETH HLA METHODOLOGY HLA Methodology

Result Interpretation

See Report

Forms
Molecular-send outs LAB11148 build edit