Sirolimus Level

Synonyms

  • FYARRO
  • HYFTOR
  • LAB875
  • MTOR INHIBITOR
  • RAPAMUNE
  • SIROLIMUS LEVEL

Cerner Name

Sirolimus(Rapamycin)

Clinical Info

Monitoring whole blood sirolimus concentration during therapy, particularly in individuals coadministered CYP3A4 substrates, inhibitors, or inducers
 
Adjusting dose to optimize immunosuppression while minimizing toxicity
 
Evaluating patient compliance

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

3 mL of EDTA whole blood

Container

Lavender Top Tube

Collection Instructions

Container/Tube:  Lavender-top (EDTA) tube(s)
Specimen:  3 mL of EDTA whole blood (0.5 mL min)
Transport Temperature:  Refrigerate
Collection Instructions:  Do not centrifuge.

Transport Instructions

Refrigerate

Specimen Stability

7 days Refrigerated

Methodology

Chemilumescent Micropartiical Immunoassay(MIA)

Days Performed

Monday through Sunday
7 am- 11 pm
 
TAT 1 Day

Performing Laboratories

Northwell Health Laboratories

CPT

80195

PDM

5950700

Results
Component Name Base Name Common Name External Name
SIROLIMUS (RAPAMYCIN) SIROLIMS SIROLIMUS RAPAMYCIN Sirolimus (Rapamycin)

Result Interpretation

4.5 - 14.0 ng/mL
 
Sirolimus Always Message:
Sirolimus target steady-state trough concentrations vary depending on the
type of transplant, concomitant immunosuppression, clinical/
institutional protocols, and time post-transplant. Results should
be interpreted in conjunction with this clinical information and any
physical signs/symptoms of rejection/toxicity. Testing performed
by Chemiluminescent Microparticle Immunoassay

Forms
Tox/TDM LAB875 build edit