Intrinsic Factor Blocking Antibodies Build info
Synonyms |
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Procedure Name |
INTRINSIC FACTOR |
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Procedure Master Number |
LAB1037 |
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Procedure ID |
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Clinical Info |
Intrinsic factor is a glycoprotein (produced by the parietal cells of the stomach) that is required for the absorption of vitamin B12 from the diet.1 During digestion, stomach acids dissociate B12 from food and intrinsic factor binds to it and allows it to be absorbed in the small intestine. Conditions that impair intrinsic factor production lead to B12 malabsorption and deficiency. Laboratory findings for B12 deficiency include decreased serum B12 levels, increased methylmalonic acid and megaloblastic anemia.2-6 Impaired hemoglobin synthesis associated with B12 deficiency is characterized by abnormal maturation of erythrocyte precursors in the bone marrow, which results in the presence of megaloblasts with hypersegmented neutrophils and decreased erythrocyte survival.4 Vitamin B12 deficiency is also associated with neurological abnormalities.5,6 |
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Specimen Sources |
Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous | ||||||||
Specimen Types |
Blood | ||||||||
Container |
Gold Top Tube |
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Collection Instructions |
Container/Tube: Gold Top Tube |
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Specimen Volume |
2 mL serum (1 mL min) |
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Transport Instructions |
Refrigerated |
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Specimen Stability |
14 Days Room Temperature, Refrigerated, Frozen |
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Methodology |
Immunochemiluminometric assay (ICMA) |
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Days Performed |
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Performing Laboratory |
LabCorp |
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CPT |
86340 |
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PDM |
5900870 | ||||||||
Only Orderable at Locations: |
Orderable Everywhere | ||||||||
Results |
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Forms |
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