BRAF and NRAS Mutation Analysis Build info

Synonyms

  • BRAF AND NRAS MUTATION ANALYSIS
  • NRAS
  • BRAF
  • LAB14286

Short Name

BRAF AND NRAS MUTATION ANALYSIS

Procedure Master Number

LAB14286

Procedure ID

184816

Clinical Info

ASSAY
DESCRIPTION: BRAF V600 mutations are associated with sensitivity to BRAF inhibitors while NRAS mutations have a prognostic
value. The NRAS/BRAF Mutation assay, performed on the Biocartis Idylla™ System using exclusively FFPE samples (Slides), combines the detection of mutations in codons 12, 13, 59, 61, 117, 146
of the NRAS gene, and mutations in codon 600 (V600E/D/K/R) of the BRAF gene.
LIMITATIONS: This assay is qualitative and is not intended to detect minimal residual disease. The assay does not distinguish between some variants for NRAS G13 (G13R/V), NRAS G12 (G12 A/V) and NRAS
A146 (A146T/V). While the assay detects BRAF V600E, V600K, V600R and V600D mutations it does not distinguish between the different variant occurring on the same nucleotide, i.e. the V600E/D or V600K/R mutations. Mutations
present below the limit of detection of the assay (5%) might not be detected 

Specimen Type

Other

Container

FFPE-Slides

Collection Instructions

Transport Instructions

Specimen Stability

Methodology

Days Performed

Performing Laboratory

CPT

PDM

Results