Celiac HLA DQ Association Build info

Synonyms

• CELIAC HLA DQ ASSOCIATION
• HLADQ
• LAB10810

Short Name

CELIAC HLA DQ ASSOCIATION

Procedure Master Number

LAB10810

Procedure ID

114140

Clinical Info

Aids in the diagnosis of celiac disease. The HLA DQ Association test provides genotyping for detection of HLA-DQ2 (DQA1*05:01 or 05:05 and DQB1*02:01 or 02:02) and HLA-DQ8 (DQB1*03:02). Patients with DQ2, half DQ2 and/or DQ8 are predisposed to celiac disease. A negative result essentially rules out celiac disease. In addition to DQ2 and DQ8 status, the report also includes complete DQA and DQB genotypes, homozygosity for DQB1*02, and genetic risk assessment.
 

Specimen Sources

Specimen Types

Container

Lavender Top Tube

Collection Instructions

Container/Tube: Lavender EDTA tube
Specimen: 7 mL whole Blood (3mL min)
Transport Temperature: Room Temperature  Protect from extreme heat or cold.
 
Limitations The HLA DQ Association test detects celiac disease-associated alleles that predispose to the disorder but is not diagnostic of celiac disease. More than 95% of celiac disease patients are positive for DQ2, half DQ2, or DQ8, but many individuals with these genetic results do not develop celiac disease. Even with appropriate precautions, an occasional specimen may not be satisfactory for testing. In such cases, fresh specimens should be collected for retesting.
 

Transport Instructions

Room Temperature  Protect from extreme heat or cold.

Specimen Stability

Methodology

Polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (Luminex®)
This is a class II antigen level and an allele level test.

Days Performed

TAT 4- 8 Days

Performing Laboratory

LabCorp of America

CPT

81377 x 2  

PDM

Only Orderable at Locations:

Results