Synonyms
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- LAB11549
- UGT1A1, FULL GENE SEQUENCING
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Cerner Name
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UGT1A1, Full Gene Sequencing
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Clinical Info
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Identifying individuals who are at increased risk of adverse drug reactions with drugs that are metabolized by UGT1A1; especially irinotecan but also atazanavir, nilotinib, pazopanib, and belinostat
Identifying individuals with Gilbert syndrome due to the presence of homozygous UGT1A1*6 (c.211G>A, based on NM_000463.2) allele, TA7, homozygous TA8, or compound heterozygous *6, TA7 or TA8
Identifying individuals who are carriers of Gilbert syndrome due to the presence of heterozygous TA7 or TA8
This test is not useful for assessment of Crigler-Najjar syndrome.
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Specimen Sources
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Blood, Arterial
Blood, Capillary
Blood, Central Line
Blood, Venous
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Specimen Types
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Blood
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Specimen Volume
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Container
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Lavender Top Tube
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Collection Instructions
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Submit only 1 of the following specimens:
Specimen Type: Whole blood
Container/Tube: Adults: Lavender top (EDTA)
Pediatrics: Purple microtube
Specimen Adults: 3 mL( 0.45 mL min)
Pediatrics: 1 mL
Collection Instructions:
1. Invert several times to mix blood.
2. Send specimen in original tube. Do not aliquot.
Specimen Stability Information: Ambient (preferred) 9 days/Refrigerated 30 days
Specimen Type: Saliva
Patient Preparation: Patient should not eat, drink, smoke, or chew gum 30 minutes prior to collection.
Container/Tube: Saliva Swab Collection Kit
Volume: One swab
Collection Instructions: Collect and send specimen per kit instructions.
Specimen Stability Information: Ambient 30 days
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Transport Instructions
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Room Temperature
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Specimen Stability
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Whole Blood
9 Days Room Temperature
30 Days Refrigerated
Saliva
30 Days Room Temperature
Extracted DNA Frozen/Room Temperature/Refrigerated
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Methodology
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Polymerase Chain Reaction (PCR) followed by DNA Sequence Analysis
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Days Performed
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TAT 8-15 Days.
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Performing Laboratories
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Mayo Medical Laboratories
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CPT
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81404
LOINC Code 93844-9
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PDM
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1759385
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Results
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| Component Name |
Base Name |
Common Name |
External Name |
| TA REPEAT RESULT |
TAREPT |
TA REPEAT RESULT |
TA Repeat Result |
| FULL GENE SEQUENCE RESULT |
FULLGENSEQ |
FULL GENE SEQUENCE RESULT |
Full Gene Sequence Result |
| PDGFRB INTERPRETATION |
PDGFRBINT |
PDGFRB INTERPRETATION |
Interpretation |
| ADDITIONAL INFORMATION |
ADDINFO |
ADDITIONAL INFORMATION |
Additional Information |
| METHOD |
METHOD |
METHOD |
Method |
| PDGFRB DISCLAIMER |
DISCLAIM |
PDGFRB DISCLAIMER |
Disclaimer |
| REVIEWEDBY |
UGT1A1REVBY |
REVIEWEDBY |
Reviewed By |
| RESULT SUMMARY |
RESULTSUMM |
RESULTSUMM, SUMMARY |
Result Summary |
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Result Interpretation
An interpretive report will be provided.
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Forms
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