Nucleophosmin (NPM1) Mutation Analysis
Test Catalog Information
| Test Catalog Synonyms | |
| EPIC Synonyms |
NPM1Q Nucleophosmin Mutation Analysis |
| Cerner Primary Mnemonic | NPM1 Mutation Analysis |
| EPIC Display Name | Nucleophosmin (NPM1) Mutation Analysis |
| Allscripts (AEHR) Order Name | NPM1 Mutation Analysis |
| Sunrise Clinical Manager (SCM) Order Name | NPM1 Mutation Analysis |
| EPIC Inpatient Orderable | Yes |
| EPIC Outpatient Orderable | Yes |
| Cerner Results |
Signing Pathologist - NPM1Q Interpretation - NPM1Q Specimen Type - NPM1Q |
| Clinical Info |
As a prognostic indicator in patients with newly diagnosed acute myelogenous leukemia with normal karyotype and no FLT3 variant and as a leukemia-specific marker of minimal residual disease. Testing Algorithm Both DNA and RNA are extracted. The assay is composed of 2 parts, an RNA-based, sensitive quantitative reverse transcription real-time polymerase chain reaction (RT-PCR) that detects and quantifies the most common altered NPM1 messenger RNA transcripts (A, B, D forms) in acute myeloid leukemia (AML), and a DNA-based qualitative NPM1 exon 12 variant screening by fragment analysis that detects essentially all altered forms reported in AML, including the rare non-A, B, D forms (with lower sensitivity at the DNA level). |
| Specimen Type |
Blood, Bone Marrow |
| Container |
Lavender Top Tube |
| Collection Instructions |
Container/Tube: Lavender Top (EDTA) Tube or Yellow ACD-B tube Specimen: 10 mL Whole Blood ( 8 mL min) or 4 mL Bone Marrow ( 2 mL min) Transport Temperature: Refrigerated |
| Transport Instructions |
Refrigerated |
| Specimen Stability |
3 Days Room Temperature 5 Days Refrigerated |
| Methodology |
RNA: Reverse-Transcription Quantitative PCR (RT-qPCR) DNA: Polymerase Chain Reaction (PCR) with Fragment Analysis by Capillary Gel Electrophoresis |
| Days Performed |
Monday - Friday |
| Performing Laboratory |
Mayo Medical Laboratories |
| CPT |
81310 |
| PDM |
235439 |
Desired Epic Build Nucleophosmin (NPM1) Mutation Analysis
| Cerner Primary Mnemonic: | NPM1 Mutation Analysis | ||||||||||||
| PDM | 235439 | ||||||||||||
| Informatics - Workgroup | Molecular-send outs | ||||||||||||
| Synonyms * | NPM1Q Nucleophosmin Mutation Analysis | ||||||||||||
| Display Name * | Nucleophosmin (NPM1) Mutation Analysis | ||||||||||||
| Order Entry Specimen Sources * | |||||||||||||
| Order Entry Specimen Types |
Blood
Bone Marrow
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| Ordering info (EPIC SmartText) | As a prognostic indicator in patients with newly diagnosed acute myelogenous leukemia with normal karyotype and no FLT3 variant and as a leukemia-specific marker of minimal residual disease. Testing Algorithm Both DNA and RNA are extracted. The assay is composed of 2 parts, an RNA-based, sensitive quantitative reverse transcription real-time polymerase chain reaction (RT-PCR) that detects and quantifies the most common altered NPM1 messenger RNA transcripts (A, B, D forms) in acute myeloid leukemia (AML), and a DNA-based qualitative NPM1 exon 12 variant screening by fragment analysis that detects essentially all altered forms reported in AML, including the rare non-A, B, D forms (with lower sensitivity at the DNA level). | ||||||||||||
| IP Orderable | Yes | ||||||||||||
| OP Orderable | Yes | ||||||||||||
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AOEs * | |||||||||||||
| AP AOEs | |||||||||||||
| Special History | No | ||||||||||||
| Build Comments | |||||||||||||
| Filter * | genetics | ||||||||||||
| Procedure Category Change | |||||||||||||
Cerner Results
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Current Actual EPIC Build as of 10/28/2024
| Procedure Id | 135356 | ||||||||||||||||||||||||
| Pdm | 235439 | ||||||||||||||||||||||||
| Order Display Name | Nucleophosmin (NPM1) Mutation Analysis | ||||||||||||||||||||||||
| Procedure Name | NPM1 MUTATION ANALYSIS | ||||||||||||||||||||||||
| Procedure Master Number | LAB12061 | ||||||||||||||||||||||||
| Short Procedure Name | NPM1 MUTATION ANALYSIS | ||||||||||||||||||||||||
| Category Code | 1.0 | ||||||||||||||||||||||||
| Category Code Record Name | LAB BLOOD ORDERABLES | ||||||||||||||||||||||||
| Synonyms | NPM1Q Nucleophosmin Mutation Analysis | ||||||||||||||||||||||||
| Clinically Active | Yes | ||||||||||||||||||||||||
| Orderable | Yes | ||||||||||||||||||||||||
| Performable | Yes | ||||||||||||||||||||||||
| Filter Genomics | Generic Genomics Procedure | ||||||||||||||||||||||||
| Reference Link Url | https://labs.northwell.edu/epic/test/135356 | ||||||||||||||||||||||||
| Ordering Instructions | |||||||||||||||||||||||||
| Default Specimen Type | Blood | ||||||||||||||||||||||||
| Specimen Type Pick List | Bone Marrow Blood | ||||||||||||||||||||||||
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| Specimen Source Pick List | Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous Bone Marrow Aspirate | ||||||||||||||||||||||||
| Specimen Source Default - Male | Blood, Venous | ||||||||||||||||||||||||
| Specimen Source Default - Female | Blood, Venous | ||||||||||||||||||||||||
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| Ip Lab Test Components For Report | |||||||||||||||||||||||||
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| Edp Ip Specimen Source | Blood, Venous Blood, Central Line Blood, Arterial Blood, Capillary | ||||||||||||||||||||||||
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| Edp Ip Specimen Type | Blood | ||||||||||||||||||||||||
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| Derived Edp Ip Buttons S | Blood, Central Line Blood, Venous Blood, Capillary Blood, Arterial | ||||||||||||||||||||||||
| Derived Edp Ip Buttons T | Blood | ||||||||||||||||||||||||
| Derived Edp Op Buttons S | |||||||||||||||||||||||||
| Derived Edp Op Buttons T | |||||||||||||||||||||||||
| Ip Orderable | 1 | ||||||||||||||||||||||||
| Op Orderable | 1 | ||||||||||||||||||||||||
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EPIC Components (results)
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