MYD88 Mutation Analysis

Synonyms

• LAB11613
• MYD88 MUTATION

Cerner Name

zzMYD88 Mutation Analysis

Clinical Info

L265P mutation in the MYD88 gene is found in approximately 90% of WaldenstrÖm macroglobulinemia and IgM-expressing lymphoplasmacytic lymphoma (LPL). There is a low incidence of L265P MYD88 mutation in other systemic CD5-negative B-cell lymphoproliferative disorders including atypical chronic lymphocytic leukemia, nodal marginal zone lymphoma (MZL), splenic MZL and mucosa-associated lymphoid tissue (MALT)-type MZL.

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous Bone Marrow Bone Marrow Aspirate

Specimen Types

Aspirate Blood Bone Marrow

Specimen Volume

Container

Lavender Top Tube

Collection Instructions

Specimen: 5 mL whole blood in EDTA lavender top (2mL min)
or
2 mL Bone Marrow in EDTA Lavender top ( 0.5 mL min)

Transport Instructions

Specimen Stability

Room temperature: 7 Days
Refrigerated: 7 Days
Frozen: Unacceptable

Methodology

Next Generation Sequencing

Days Performed

TAT: 6 Days

Performing Laboratories

Quest Diagnostics Nichols Institute

CPT

81305
Loinc code; Pending assignment

PDM

225202

Results

Result Interpretation

Forms