The Verifi Prenatal Test with Microdeletions is a non-invasive screening option for chromosomes 13, 18, and 21, and fetal sex chromosome aneuploidies in both singleton and twin pregnancies. It is a non-invasive screening option for standard chromosome aneuploidies, certain microdeletions, and all autosomes. Expanded panels (microdeletions or all autosomes) are optional add-ons for singleton pregnancies.
Specimen Type
Blood
Container
Collection Instructions
Container/Tube: One to Two Streck BCT tube(s) Specimen: 10 ml whole blood (7 ml min) Transport Temperature: Room Temperature
Note: Illumina request form completely filled out is required.
The following information is required with each specimen: 1. Reason for referral 2. Maternal age 3. Number of fetuses 4. Gestation age (weeks and days) 5. Method of determining gestational age 6. Maternal height (inches) 7. Maternal weight (pounds) The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be delayed or compromised. Check off for Sex Chromosome aneuploids
Transport Instructions
Room Temperature
Specimen Stability
Methodology
Nucleic Acid extraction, DNA sequencing, and analysis of sequencing to determine fetal aneuploidy.
Days Performed
Microdeletion syndromes 1p36 deletion 4p- (Wolf-Hirschhorn syndrome) 5p- (cri-du-chat syndrome) 15q11 (Prader-Willi syndrome/Angelman syndrome) 22q11 deletion (DiGeorge) Testing Indications: Advanced maternal age (> 35 years) Positive serum screen Abnormal ultrasound History suggestive of increased risk for the specified chromosome aneuploidies Low risk/maternal anxiety Screens for: Trisomy 21 (Down syndrome) Trisomy 18 (Edwards syndrome) Trisomy 13 (Patau syndrome) Fetal sex aneuploidies
