Aid in the diagnosis of urine concentration disorders, especially diabetes insipidus, syndrome of inappropriate ADH (SIADH), psychogenic water intoxication, and syndrome of ectopic ADH production.
ADH, produced in the supraoptic and paraventricular locations of the hypothalamus, acts on the collecting tubules of the kidney to cause increase in permeability to water and urea. ADH release is triggered by a number of both osmotic and nonosmotic stimuli. Measurement of ADH is useful in separating central diabetes insipidus, which is marked by polydipsia and polyuria and is caused by inadequate ADH production from nephrogenic diabetes insipidus caused by the inability of renal tubules to respond to ADH. In SIADH, release of ADH is disproportionate to a low serum osmolality. SIADH results due to a number of conditions such as pulmonary disease, head trauma, and cancer. Please submit separate Lavender top tube for this test- Cannot be shared
Specimen Type
Blood
Container
Lavender Top Tube
Collection Instructions
Container/Tube: Lavender (EDTA) tube Specimen: 2 mL plasma (1.2 ml min) Transport Temperature: Frozen Stability: Room Temperature: 2 Hours Refrigerated; Unacceptable Frozen: 30 Days Collection: Separate plasma from cells ASAP or within 2 hours of collection Patient Preparation No isotopes administered within 24 hours prior to venipuncture.
Transport Instructions
Frozen
Specimen Stability
Room Temperature: 2 Hours Refrigerated; Unaceptable Frozen: 30 Days Collection: Separate plasma from cells ASAP or within 2 hours of collection
