Librium (Chlordiazepoxide) Level

Synonyms

  • CHLORDIAZEPOXIDE
  • CHLORDIAZEPOXIDE LEVEL, SERUM
  • LAB11355

Cerner Name

Librium (Chlodiazepoxide)

Clinical Info

Use to optimize dosing and monitor patient adherence.
Includes: Librium (Chlordiazepide)and Nordiazepam

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

2 mL serum or plasma (1 mL min)

Container

Red Top Tube

Collection Instructions

Container/Tube: Red Top Tube or Gray Top Tube
Specimen: 2 mL Serum or Plasma (1 mL min)
Transport Temperature: Refrigerated
Centrifuge and aliquot serum into vial within 2 hours of collection.
Patient Preparation More information
Timing of specimen collection: Predose (trough) draw at steady state concentration.

Transport Instructions

Specimen Stability

1 Week Room Temperature
2 Weeks Refrigerated (preferred)
3 years Frozen

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Days Performed

TAT: 2 - 8 Days

Performing Laboratories

ARUP Laboratories

CPT

80346
(Atl Code; G0480)

PDM

5915200

Results
Component Name Base Name Common Name External Name
CHLORDIAZEPOXIDE LEVEL, SERUM CHLORDIAZ CHLORDIAZEPOXIDE LEVEL, SERUM Librium
D METHYL CHLORDIAZEPOXIDE DMETHYCHLO D METHYL CHLORDIAZEPOXIDE D Methyl Chlordiazepoxide
CHLORDIAZEPOXIDE TOTAL CHLORDIAZ CHLORDIAZEPOXIDE TOTAL Chlordiazepoxide Total
NORDIAZEPAM RESULT NORDIAZEPAM NORDIAZ, RESULT Nordiazepam

Result Interpretation

Therapeutic concentration:

Chlordiazepoxide: 500-3,000 ng/mL-Dose (afult): 5-100 mg)

               Toxic: Greater than 5000 ng/mL

Nordiazepam: 100-500 ng/mL- Based ib normal doses

           Toxic: Greater than 2500 ng/mL

Forms
Tox/TDM LAB11355 build edit