HLA B*58:01, Allopurinol Hypersensitivity Build info

Synonyms

  • HLA B*58:01
  • HLAB58
  • LAB11554

Short Name

HLA B*58:01

Procedure Master Number

LAB11554

Procedure ID

115423

Clinical Info


Allopurinol associated SCAR (severe cutaneous adverse drug reaction) including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) has been shown to be associated with the human leukocyte antigen (HLA) B*58:01 of the major histocompatibility complex (MHC). The MHC family of genes codes for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T-cell receptors to elicit an immune response. The presence of the HLA B*58:01 allele increases the susceptibility to allopurinol SCAR in several populations studied.

Specimen Type

Blood

Container

Lavender Top Tube

Collection Instructions

Container/Tube: Lavender Top tube
Specimen: 7 mL whole Blood ( 7 mL min)
Transport Temperature: Room Temperature
Stability: Maintain at Room Temperature or Refrigerated

Transport Instructions

Room Temperature

Specimen Stability

Maintain at Room Temperature or Refrigerated

Methodology

Sequence-based typing (SBT), sequence-specific oligonucleotide probes (SSOP), and/or sequence-specific primers (SSP) as needed to obtain the required resolution

Days Performed

TAT: 4-8 Days

Performing Laboratory

LabCorp

CPT

81381
LOINC Code: 13299-3

PDM

225201

Results
Component Name Base Name Common Name External Name
HLA METHODOLOGY HLAMETH HLA METHODOLOGY Hla Methodology
HLA-B HLAB HLA B Hla-B
HLAB RESULTS HLABRES HLAB RESULTS Hlab Results