This test is not orderable.

HLA B*58:01, Allopurinol Hypersensitivity

Synonyms

  • HLA B*58:01
  • HLAB58
  • LAB11554

Cerner Name

HLA B*58:01

Clinical Info


Allopurinol associated SCAR (severe cutaneous adverse drug reaction) including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) has been shown to be associated with the human leukocyte antigen (HLA) B*58:01 of the major histocompatibility complex (MHC). The MHC family of genes codes for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T-cell receptors to elicit an immune response. The presence of the HLA B*58:01 allele increases the susceptibility to allopurinol SCAR in several populations studied.

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Container

Lavender Top Tube

Collection Instructions

Container/Tube: Lavender Top tube
Specimen: 7 mL whole Blood ( 7 mL min)
Transport Temperature: Room Temperature
Stability: Maintain at Room Temperature or Refrigerated

Specimen Volume

7 mL whole Blood ( 7 mL min)

Transport Instructions

Room Temperature

Specimen Stability

Maintain at Room Temperature or Refrigerated

Methodology

Sequence-based typing (SBT), sequence-specific oligonucleotide probes (SSOP), and/or sequence-specific primers (SSP) as needed to obtain the required resolution

Days Performed

TAT: 4-8 Days

Performing Laboratory

LabCorp

CPT

81381
LOINC Code: 13299-3

PDM

225201

Only Orderable at Locations:

Orderable Everywhere

Results
Component Name Base Name Common Name External Name
HLA-B HLAB HLA B HLA-B
HLAB RESULTS HLABRES HLAB RESULTS HLA-B Results
HLA METHODOLOGY HLAMETH HLA METHODOLOGY HLA Methodology

Result Interpretation

Reference Range: See Report

Forms
LAB11554 build edit