c-KIT Mutation Analysis in Tumors of Hematopoietic Tissue

Synonyms

  • C-KIT MUTATION ANALYSIS
  • KITB
  • LAB11023

Cerner Name

c-KIT Mutation analysis

Clinical Info

c-KIT is a proto-oncogene that encodes a type III transmembrane tyrosine kinase. c-KIT and its ligand stem cell factor have a key role in survival, proliferation, differentiamyeloid leukemia (AML), and approximately 20% high-grade myelodysplastic syndrome (MDS) and MDS-derived AML. c-KIT mutation in AML confers increased risk of relapse and decreased overall survival. 
 

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

3 - 5 mL Whole Blood or 2 mL Bone Marrow (3 mL blood and 1 mL Bone Marrow min)

Container

Lavender Top Tube

Collection Instructions

Container/Tube: Lavender EDTA tube or Green Sodium Heparin tube
Specimen: 3 - 5 mL Whole Blood or 2 mL Bone Marrow (3 mL blood and 1 mL Bone Marrow min)
Transport Temperature: Room Temperature
Stability: 3 Days Room Temperature
7 Days Refrigerated

Transport Instructions

Room Temperature

Specimen Stability

3 Days Room Temperature
7 Days Refrigerated

Methodology

Polymerase chain reaction (PCR) and DNA sequencing

Days Performed

LabCorp Test code 480940
TAT: 11-15 Days

Performing Laboratories

LabCorp

CPT

81272

PDM

2059793

Results
Component Name Base Name Common Name External Name
C-KIT MA ANALYSIS RESULT CKITMARES C KIT MA ANALYSIS RESULT c-KIT Mutation Analysis Result
C-KIT AMINO ACID CHANGE CKITAA C KIT AMINO ACID CHANGE c-KIT Amino Acid Change
C-KIT NUCLEOTIDE CHANGE CKITNC C KIT NUCLEOTIDE CHANGE c-KIT Nucleotide Change
C-KIT BACKGROUND CKITBG C KIT BACKGROUND c-KIT Background
C-KIT REFERENCE CKITREF C KIT REFERENCE c-KIT Reference
C-KIT METHODOLOGY CKITMETHOD C KIT METHODOLOGY c-KIT Methodology
C-KIT DISCLAIMER CKITDISC C KIT DISCLAIMER c-KIT Disclaimer
C-KIT DIRECTOR CKITDIR C KIT DIRECTOR c-KIT Director Review

Result Interpretation

See Report
 
TAT: 11- 15 Days

Forms
Molecular-send outs LAB11023 build edit