Serotonin Blood

Synonyms

LAB11004
SEROTONIN, BLOOD

Cerner Name

Clinical Info

Useful For
In conjunction with, or as an alternative to, first-order tests in the differential diagnosis of isolated symptoms suggestive of carcinoid syndrome,
in particular flushing (5-hydroxyindoleacetic acid or serum chromogranin A measurements are first-line tests)

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

Specimen Volume: 2.5 mL

Container

Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Serotonin tube containing ascorbic acid

Collection Instructions

Container/Tube: Serotonin Tube
Collection Instructions:
1. Immediately after collection, transfer approximately 2.5 mL of whole blood to the serotonin tube and mix well
(any volume of whole blood from 1.5-3 mL is acceptable).
2. Immediately freeze specimen (necessary to lyse the red blood cells).

Transport Instructions

Frozen Temperature

Specimen Stability

Whole Blood EDTA Frozen 90 days in SEROTONIN TUBE

Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Days Performed

TAT 6-9 Days

Performing Laboratories

Mayo Medical Laboratories

CPT

84260
LOINC Code: 2939-7

PDM

5901780

Results

Component Name	Base Name	Common Name	External Name
SEROTONIN BLOOD	SEROTONIN	SEROTONIN BLOOD	Serotonin Blood

Result Interpretation

Reference Values: < or =330 ng/mL

Patient Preparation: Patient should not take medications that may elevate serotonin levels, including lithium,
monoamine oxidase inhibitors, methyldopa, morphine, and reserpine, or selective serotonin reuptake inhibitors (SSRI, eg, PROZAC)
which can lead to depletion of platelet serotonin levels and result in false-negative serotonin results for a minimum
of 72 hours before specimen collection. Some drugs with longer half-lives (i.e. fluoxetine) can require months
after discontinuation for serotonin levels to return to baseline.

Forms

Endocrine LAB11004

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