CYP2C19 Genotyping

Synonyms

• CYP2C19 GENOTYPING
• CYTOCHROME P450 2C19 GENOTYPE
• LAB1999

Cerner Name

CYP2C19 Genotype

Clinical Info

Cytochrome P450 2C19 (CYP2C19) is a drug-metabolizing enzyme involved in the metabolism of several clinically important drugs including the 
platelet aggregation inhibitor clopidogrel, the tricyclic antidepressants amitriptyline and nortriptyline, the selective serotonin reuptake inhibitors 
citalopram and sertraline, and some proton pump inhibitors including omeprazole and pantoprazole.

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

2 ml whole blood or one Buccal Swab

Container

Lavender Top Tube

Collection Instructions

Container/Tube: Lavender top or Yellow ACD Tube or Buccal Swab
Specimen; 3 mL Whole Blood (1.0 mL min)
                   4 Buccal Swabs (2 Swabs min)
Causes
for Rejection:
Quantity not sufficient for analysis; buccal swab;
buccal swabs without outer collection envelope;
severely damaged buccal swab envelope; buccal swab
envelope received open; frozen glass tube

Transport Instructions

Room Temperature

Specimen Stability

Room Temperature Whole Blood: 28 days
                              Swabs: 2 Months
Refrigerated
                             Whole Blood: 28 days
                             Swabs: Unstable
Frozen
                           Whole  Blood 2 Years
                           Swab  Unacceptable

Methodology

DNA analysis is performed by allele-specific real-time polymerase chain reactions (RT-PCR) to detect single-nucleotide polymorphisms (SNPs) 
within the CYP2C19 gene and to assign variant CYP2C19 *2, *3, *4, *5, *6, *7, *8, *9, *10, *17 and *35 alleles. *1 denotes detection of the reference 
(wild-type) sequence at the assessed alleles. No other variants in this gene are detected by this assay.

Days Performed

TAT: 8-11 Days

Performing Laboratories

Monogram Biosciences Inc
345 Oyster Point Blvd, S San Francisco, CA

CPT

81225
LOINC Code: 57132-3

PDM

5906087

Results

Result Interpretation

Forms