Cytochrome p450 2C19 Genotype

Cytochrome P450 2C19 Genotype

Cytochrome P450 2C19 (CYP2C19) is a drug-metabolizing enzyme involved in the metabolism of several clinically important drugs including the  platelet aggregation inhibitor clopidogrel, the tricyclic antidepressants amitriptyline and nortriptyline, the selective serotonin reuptake inhibitors  citalopram and sertraline, and some proton pump inhibitors including omeprazole and pantoprazole.

Blood, Other

Lavender Top Tube

Container/Tube: Lavender top or Yellow ACD Tube or Buccal Swab Specimen; 3 mL Whole Blood (1.0 mL min)                    4 Buccal Swabs (2 Swabs min) Causes for Rejection: Quantity not sufficient for analysis; buccal swab; buccal swabs without outer collection envelope; severely damaged buccal swab envelope; buccal swab envelope received open; frozen glass tube

Room Temperature

Room Temperature Whole Blood: 28 days                               Swabs: 2 Months Refrigerated                              Whole Blood: 28 days                              Swabs: Unstable Frozen                            Whole  Blood 2 Years                            Swab  Unacceptable

DNA analysis is performed by allele-specific real-time polymerase chain reactions (RT-PCR) to detect single-nucleotide polymorphisms (SNPs)  within the CYP2C19 gene and to assign variant CYP2C19 *2, *3, *4, *5, *6, *7, *8, *9, *10, *17 and *35 alleles. *1 denotes detection of the reference  (wild-type) sequence at the assessed alleles. No other variants in this gene are detected by this assay.

TAT: 8-11 Days

Monogram Biosciences Inc 345 Oyster Point Blvd, S San Francisco, CA

81225 LOINC Code: 57132-3

5906087