MPL Mutation Molecular Detection
Test Catalog Information
| Test Catalog Synonyms | |
| EPIC Synonyms |
HLX MPL Mutation Analysis Case MPL Mutation Analysis JAK-2 negative MPN diagnosis, JAK2 V617 negative testing MPLMUT |
| Cerner Primary Mnemonic | HLX MPL Mutation Analysis Case |
| EPIC Display Name | MPL Mutation Molecular Detection |
| Allscripts (AEHR) Order Name | MPL Mutation Analysis Case |
| Sunrise Clinical Manager (SCM) Order Name | MPL Mutation Analysis |
| EPIC Inpatient Orderable | Yes |
| EPIC Outpatient Orderable | Yes |
| Cerner Results | |
| Clinical Info |
The MPL gene is located on chromosome 1p34, it contains 12 exons. MPL mutations lead to a gain of function and receptor activation in the absence of thrombopoietin binding with constitutional activation of the JAK-STAT signaling pathway. The mutations can occur in Essential Thrombcythemia (ET) and Primary Myelofibrosis (PMF) and have not been reported in Polycythemia Vera (PV). The most common pathological variants causing gain of function in the MPL gene are located in exon 10: W515L, W515K, W515A and S505N. |
| Specimen Type |
Blood, Bone Marrow |
| Container |
Lavender Top Tube |
| Collection Instructions |
Container/Tube: Lavender top (EDTA) tube Specimen: 1-3 mL of bone marrow or peripheral blood Transport Temperature: room temperature or at 4C with ice cold packs |
| Transport Instructions |
room temperature or at 4C with ice cold packs |
| Specimen Stability |
Specimens are stable for a week refrigerated. |
| Methodology |
Polymerase Chain Reaction (PCR) with capillary electrophoresis |
| Days Performed |
Monday through Friday TAT: 8 Calendar days |
| Performing Laboratory |
Northwell Health Laboratories - Manhasset |
| CPT |
81338 LOINC Code: 62947-7 |
| PDM |
1559701 |
Desired Epic Build MPL Mutation Molecular Detection
| Cerner Primary Mnemonic: | HLX MPL Mutation Analysis Case |
| PDM | 1559701 |
| Informatics - Workgroup | Molpath inhouse |
| Synonyms * | HLX MPL Mutation Analysis Case MPL Mutation Analysis JAK-2 negative MPN diagnosis, JAK2 V617 negative testing MPLMUT |
| Display Name * | MPL Mutation Molecular Detection |
| Order Entry Specimen Sources * | |
| Order Entry Specimen Types |
Aspirate
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| Specimen Navigator Specimen Types | |
| Specimen Navigator Specimen Sources | |
| Specimen Navigator Short Name | |
| Ordering info (EPIC SmartText) | The MPL gene is located on chromosome 1p34, it contains 12 exons. MPL mutations lead to a gain of function and receptor activation in the absence of thrombopoietin binding with constitutional activation of the JAK-STAT signaling pathway. The mutations can occur in Essential Thrombcythemia (ET) and Primary Myelofibrosis (PMF) and have not been reported in Polycythemia Vera (PV). The most common pathological variants causing gain of function in the MPL gene are located in exon 10: W515L, W515K, W515A and S505N. |
| IP Orderable | Yes |
| OP Orderable | Yes |
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AOEs * | |
| AP AOEs | |
| Special History | Yes |
| Build Comments | |
| Filter * | genetics |
| Procedure Category Change | |
| Cerner Results | |
Current Actual EPIC Build as of 10/28/2024
| Procedure Id | 115149 | ||||||||||||||||||||||||
| Pdm | 1559701 | ||||||||||||||||||||||||
| Order Display Name | MPL Mutation Molecular Detection | ||||||||||||||||||||||||
| Procedure Name | MPL MUTATION ANALYSIS | ||||||||||||||||||||||||
| Procedure Master Number | LAB11404 | ||||||||||||||||||||||||
| Short Procedure Name | MPL MUTATION ANALYSIS | ||||||||||||||||||||||||
| Category Code | 21.0 | ||||||||||||||||||||||||
| Category Code Record Name | LAB MOLECULAR DIAGNOSTICS ORDERABLES | ||||||||||||||||||||||||
| Synonyms | HLX MPL MUTATION ANALYSIS CASE MPL MUTATION ANALYSIS JAK-2 NEGATIVE MPN DIAGNOSIS, JAK2 V617 NEGATIVE TESTING MPLMUT | ||||||||||||||||||||||||
| Clinically Active | Yes | ||||||||||||||||||||||||
| Orderable | Yes | ||||||||||||||||||||||||
| Performable | Yes | ||||||||||||||||||||||||
| Filter Genomics | Generic Genomics Procedure | ||||||||||||||||||||||||
| Reference Link Url | https://labs.northwell.edu/epic/test/115149 | ||||||||||||||||||||||||
| Ordering Instructions | |||||||||||||||||||||||||
| Default Specimen Type | Blood | ||||||||||||||||||||||||
| Specimen Type Pick List | Bone Marrow Blood | ||||||||||||||||||||||||
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| Specimen Source Pick List | Bone Marrow Aspirate Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous | ||||||||||||||||||||||||
| Specimen Source Default - Male | Blood, Venous | ||||||||||||||||||||||||
| Specimen Source Default - Female | Blood, Venous | ||||||||||||||||||||||||
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| Ip Lab Test Components For Report | HLXMPLFR:10 | ||||||||||||||||||||||||
| Op Lab Test Components For Report | HLXMPLFR:10 | ||||||||||||||||||||||||
| Order Questions | ["3045300170", "3045300171", "3045300173"] | ||||||||||||||||||||||||
| Order Questions Record Name | NH IP HOME COLLECT DATE NH IP HOME COLLECT DAYS NH IP HOME COLLECT MEDICALLY NECESSARY | ||||||||||||||||||||||||
| Inpatient Order Questions | ["3048500000"] | ||||||||||||||||||||||||
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| Order Specific Question Override | Yes | ||||||||||||||||||||||||
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| Edp Amb Order Specific Questions Record Name | NH IP PATIENT COMPLETED CONSENT | ||||||||||||||||||||||||
| Edp Ip Order Specific Questions Record Name | NH IP PATIENT COMPLETED CONSENT | ||||||||||||||||||||||||
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| Ip Orderable | 1 | ||||||||||||||||||||||||
| Op Orderable | 1 | ||||||||||||||||||||||||
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