Inpatient and Outpatient Orderable

Paraneoplastic Autoantibody Evaluation, Serum Build info

Synonyms

  • PARANEOPLASTIC EVALUATION
  • PARANEOPLASTIC NEUROLOGICAL AUTOIMMUNITY
  • LAB10818

Procedure Name

PARANEOPLASTIC EVALUATION

Procedure Master Number

LAB10818

Procedure ID

114154

Clinical Info

Serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, 
especially those with known risk factors for cancer
Directing a focused search for cancer
Investigating neurological symptoms that appear during, or after, cancer therapy and are not explainable by metastasis
Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy
Monitoring the immune response of seropositive patients during cancer therapy
Detecting early evidence of cancer recurrence in previously seropositive patients

Specimen Sources

 Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

 Blood

Container

Gold Top Tube

Collection Instructions

Container/Tube: Red top tube or Gold Top Tube
Specimen : 4 mL serum (2 mL min)
Transport Temperature: Refrigerated
Patient Preparation:
1. For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication 
or intravenous immunoglobulin treatment.
2. This test should not be requested for patients who have recently received radioisotopes, therapeutically or diagnostically, 
because of potential assay interference.
 The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the 
clearance rate in the individual patient. 
Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 
1 week and assayed if sufficiently decayed or canceled if radioactivity remains.

Specimen Volume

4 mL serum (2 mL min)

Transport Instructions

Refrigerated

Specimen Stability

3 days Room Temperature
28 Days Refrigerated or Frozen

Methodology

Indirect Immunofluorescence Assay (IFA)
Radioimmunoassay (RIA)
Western Blot (WB)
Immunoblot (IB)
Cell-Binding Assay (CBA)

Days Performed

TAT: 11-18 Days

Performing Laboratory

Mayo Medical Laboratories

CPT

83516
86596
86255 x 9
LOINC Code: 43104-9

PDM

 5910633

Only Orderable at Locations:

 Orderable Everywhere

Results
Component Name Base Name Common Name External Name
AMPHIPHYSIN AB, S AMPHIPABS AMPHIP AB S Amphiphysin Ab, S
AGNA-1, S AGNA1S AGNA 1 S AGNA-1, S
ANNA-1, S ANNA1S ANNA 1 S ANNA-1, S
ANNA-2, S ANNA2S ANNA 2 S ANNA-2, S
ANNA-3, S ANNA3S ANNA 3 S ANNA-3, S
CRMP-5-IGG WESTERN BLOT CR5IGWESBLOT CR 5 IGG WES BLOT CRMP-5-IgG, S
NEURONAL (V-G) K+ CHANNEL AB, S VGKCHANAB NEURONAL VOLTAGE GATED K CHANNEL AB Neuronal (V-G) K+ Channel Ab, S
P/Q-TYPE ANTIBODY PQTYPEANTI P Q TYPE ANTIBODY P/Q-Type Calcium Channel Ab
PCA-1, S PCA1S PCA 1 S PCA-1, S
PCA-2, S PCA2S PCA 2 S PCA-2, S
PCA-TR, S PCATRS PCA TR S PCA-Tr, S
INTERPRETIVE COMMENTS PARANEOPLINT INTERPRETIVE COMMENTS Interpretive Comments
IFA NOTES IFANOTES IFA NOTES IFA Notes

Result Interpretation

Test ID

Reporting name

Methodology*

Reference value

PAINT

Interpretive Comments

Medical interpretation

Not applicable

AMPHS

Amphiphysin Ab, S

IFA

Negative

AGN1S

Anti-Glial Nuclear Ab, Type 1

IFA

Negative

ANN1S

Anti-Neuronal Nuclear Ab, Type 1

IFA

Negative

ANN2S

Anti-Neuronal Nuclear Ab, Type 2

IFA

Negative

ANN3S

Anti-Neuronal Nuclear Ab, Type 3

IFA

Negative

CRMS

CRMP-5-IgG, S

IFA

Negative

VGKC

Neuronal (V-G) K+ Channel Ab, S

RIA

< or =0.02 nmol/L

CCPQ

P/Q-Type Calcium Channel Ab

RIA

< or =0.02 nmol/L

PCABP

Purkinje Cell Cytoplasmic Ab Type 1

IFA

Negative

PCAB2

Purkinje Cell Cytoplasmic Ab Type 2

IFA

Negative

PCATR

Purkinje Cell Cytoplasmic Ab Type Tr

IFA

Negative

Reflex Tests:

Test ID

Reporting name

Methodology*

Reference value

AGNBS

AGNA-1 Immunoblot, S

IB

Negative

AGNTS

AGNA-1 Titer, S

IFA

<1:240

AMIBS

Amphiphysin Immunoblot, S

IB

Negative

AN1BS

ANNA-1 Immunoblot, S

IB

Negative

AN1TS

ANNA-1 Titer, S

IFA

<1:240

AN2BS

ANNA-2 Immunoblot, S

IB

Negative

AN2TS

ANNA-2 Titer, S

IFA

<1:240

AN3TS

ANNA-3 Titer, S

IFA

<1:240

APHTS

Amphiphysin Ab Titer, S

IFA

<1:240

CRMTS

CRMP-5-IgG Titer, S

IFA

<1:240

CS2CS

CASPR2-IgG CBA, S

CBA

Negative

CRMWS

CRMP-5-IgG Western Blot, S

WB

Negative

LG1CS

LGI1-IgG CBA, S

CBA

Negative

PC1BS

PCA-1 Immunoblot, S

IB

Negative

PC1TS

PCA-1 Titer, S

IFA

<1:240

PC2TS

PCA-2 Titer, S

IFA

<1:240

PCTBS

PCA-Tr Immunoblot, S

IB

Negative

PCTTS

PCA-Tr Titer, S

IFA

<1:240

Forms
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