Calreticulin (CALR) Mutation Molecular Detection
Test Catalog Information
| Test Catalog Synonyms | |
| EPIC Synonyms |
JAK2-negative myeloproliferative neoplasm Myeloproliferative disorders |
| Cerner Primary Mnemonic | HLX CALR CASE |
| EPIC Display Name | Calreticulin (CALR) Mutation Molecular Detection |
| Allscripts (AEHR) Order Name | HLX Calreticulin Case (HLX CALR CASE) |
| Sunrise Clinical Manager (SCM) Order Name | Calreticulin Gene Mutation Analysis |
| EPIC Inpatient Orderable | Yes |
| EPIC Outpatient Orderable | Yes |
| Cerner Results | |
| Clinical Info |
The most common mutation in patients with myeloproliferative neoplasms polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) is JAK2 V617F. CALR somatic mutations are seen in a large subset of patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF) who lack JAK2 and MPL mutations. CALR mutations are not found in patients with PV. Patients with a mutated CALR have a higher level of platelets, lower hemoglobin, a lower rate of thrombosis and overall better outcome than patients with a JAK2 or MPL mutation. |
| Specimen Type |
Blood, Bone Marrow |
| Container |
Lavender Top Tube |
| Collection Instructions |
Peripheral Blood or Bone marrow Container/Tube: Lavender-top (EDTA) tube Specimen: 1-3 mL peripheral blood or Bone marrow |
| Transport Instructions |
room temperature or at 4C with ice cold packs |
| Specimen Stability |
Specimens are stable for a week refrigerated. |
| Methodology |
Polymerase Chain Reaction (PCR) Amplification/Capillary Electrophoresis |
| Days Performed |
Monday through Friday TAT: 8 Calendar days |
| Performing Laboratory |
Northwell Health Laboratories |
| CPT |
83891 - DNA extract-purify 81219 |
| PDM |
1763033 |
Desired Epic Build Calreticulin (CALR) Mutation Molecular Detection
| Cerner Primary Mnemonic: | HLX CALR CASE |
| PDM | 1763033 |
| Informatics - Workgroup | Molpath inhouse |
| Synonyms * | JAK2-negative myeloproliferative neoplasm Myeloproliferative disorders |
| Display Name * | Calreticulin (CALR) Mutation Molecular Detection |
| Order Entry Specimen Sources * | |
| Order Entry Specimen Types |
Aspirate
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| Specimen Navigator Specimen Types | |
| Specimen Navigator Specimen Sources | |
| Specimen Navigator Short Name | |
| Ordering info (EPIC SmartText) | The most common mutation in patients with myeloproliferative neoplasms polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) is JAK2 V617F. CALR somatic mutations are seen in a large subset of patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF) who lack JAK2 and MPL mutations. CALR mutations are not found in patients with PV. Patients with a mutated CALR have a higher level of platelets, lower hemoglobin, a lower rate of thrombosis and overall better outcome than patients with a JAK2 or MPL mutation. |
| IP Orderable | Yes |
| OP Orderable | Yes |
|
AOEs * | |
| AP AOEs | |
| Special History | Yes |
| Build Comments | |
| Filter * | genetics |
| Procedure Category Change | |
| Cerner Results | |
Current Actual EPIC Build as of 10/28/2024
| Procedure Id | 115607 | ||||||||||||||||||||||||
| Pdm | 1763033 | ||||||||||||||||||||||||
| Order Display Name | Calreticulin (CALR) Mutation Molecular Detection | ||||||||||||||||||||||||
| Procedure Name | CALRETICULIN GENE MUTATION ANALYSIS | ||||||||||||||||||||||||
| Procedure Master Number | LAB11646 | ||||||||||||||||||||||||
| Short Procedure Name | CALRETICULIN GENE MUTATION ANALYSIS | ||||||||||||||||||||||||
| Category Code | 21.0 | ||||||||||||||||||||||||
| Category Code Record Name | LAB MOLECULAR DIAGNOSTICS ORDERABLES | ||||||||||||||||||||||||
| Synonyms | JAK2-NEGATIVE MYELOPROLIFERATIVE NEOPLASM MYELOPROLIFERATIVE DISORDERS | ||||||||||||||||||||||||
| Clinically Active | Yes | ||||||||||||||||||||||||
| Orderable | Yes | ||||||||||||||||||||||||
| Performable | Yes | ||||||||||||||||||||||||
| Filter Genomics | Generic Genomics Procedure | ||||||||||||||||||||||||
| Reference Link Url | https://labs.northwell.edu/epic/test/115607 | ||||||||||||||||||||||||
| Ordering Instructions | |||||||||||||||||||||||||
| Default Specimen Type | Blood | ||||||||||||||||||||||||
| Specimen Type Pick List | Bone Marrow Blood | ||||||||||||||||||||||||
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| Op Specimen Type List | |||||||||||||||||||||||||
| Specimen Source Pick List | Bone Marrow Aspirate Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous | ||||||||||||||||||||||||
| Specimen Source Default - Male | Blood, Venous | ||||||||||||||||||||||||
| Specimen Source Default - Female | Blood, Venous | ||||||||||||||||||||||||
| Specimen Source List | |||||||||||||||||||||||||
| Op Specimen Source List | |||||||||||||||||||||||||
| Ip Lab Test Components For Report | HLXCALR:10 | ||||||||||||||||||||||||
| Op Lab Test Components For Report | HLXCALR:10 | ||||||||||||||||||||||||
| Order Questions | ["3045300170", "3045300171", "3045300173"] | ||||||||||||||||||||||||
| Order Questions Record Name | NH IP HOME COLLECT DATE NH IP HOME COLLECT DAYS NH IP HOME COLLECT MEDICALLY NECESSARY | ||||||||||||||||||||||||
| Inpatient Order Questions | ["3048500000"] | ||||||||||||||||||||||||
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| Order Specific Question Override | Yes | ||||||||||||||||||||||||
| Inpatient Question Override | |||||||||||||||||||||||||
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| Location Restrict List Includes Op | |||||||||||||||||||||||||
| Edp Amb Order Specific Questions Record Name | NH IP PATIENT COMPLETED CONSENT | ||||||||||||||||||||||||
| Edp Ip Order Specific Questions Record Name | NH IP PATIENT COMPLETED CONSENT | ||||||||||||||||||||||||
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| Derived Edp Ip Buttons S | |||||||||||||||||||||||||
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| Derived Edp Op Buttons S | |||||||||||||||||||||||||
| Derived Edp Op Buttons T | |||||||||||||||||||||||||
| Ip Orderable | 1 | ||||||||||||||||||||||||
| Op Orderable | 1 | ||||||||||||||||||||||||
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