CXCR4 C1013G Mutation Molecular Detection

Synonyms	CXCR4 C1013G MUTATION ANALYSIS LAB14273
Cerner Name	HLX CXCR4 C1013G Case
Clinical Info	CXCR4 C1013G Mutation Analysis CXCR4 C1013G mutation has been described as the most frequent recurrent CXCR4 mutation identified in WM patients. Most of these cases with CXCR4 mutations have concurrent MYD88 L265P mutations. This patient may be eligible for treatment with ibrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor. CXCR4 mutations are associated with resistance to ibrutinib in patients with WM.
Specimen Sources	Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous Bone Marrow
Specimen Types	Blood Bone Marrow
Specimen Volume	1-3 mL Whole blood or Bone Marrow
Container	Lavender Top Tube
Collection Instructions	Container/Tube: Lavender Top Tube Specimen 1 - 3 mL Whole Blood or Bone Marrow
Transport Instructions	Room Temperature
Specimen Stability	Specimens are stable for a week refrigerated
Methodology	Allele Specific Real Time Polymerase Chain Reaction (RT-PCR)
Days Performed	Monday through Friday TAT: 8 Calendar days
Performing Laboratories	Northwell Health Laboratories
CPT	81479
PDM	248466
Results
Result Interpretation Detected (mutation is present) Not detected (mutation is absent)
Forms	Molecular test Requisition Form Heme/Onc Requisition

Molpath Inhouse LAB14273

Synonyms