Inpatient and Outpatient Orderable

Voltage-Gated Potassium Channel (VGKC) Antibody with Reflex to LGI1 and CASPR2 Screen and Titer

Synonyms

  • LAB11122
  • LGKC AB W/REFLEX TO LGI1 & CASPR2
  • VGKC AB WITH REFLEX TO LGI1 AND CASPR2 SCREEN AND TITER
  • VGKCRFX

Cerner Name

VGKC Ab with Reflex to LGI1 and CASPR2 Screen and Titer

Clinical Info

Screening test for voltage-gated potassium channel (VGKC) antibody receptor complex-associated autoantibodies with test reflex to CASPR2 and LGI1 antibodies. Antibodies are associated with acquired neuromyotonia, limbic encephalitis, painful neuropathy, Morvan syndrome, and rare tumors (eg, thymoma, small-cell lung cancer).

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

4 mL serum ( 0.5 mL min)

Container

Gold Top Tube

Collection Instructions

Container/Tube: Gold To[ Tube
Specimen: 4 mL serum ( 0.5 mL min)
Transport Temperature: Refrigerated
Separate serum from cells within 1 hour.

Transport Instructions

Refrigerated

Specimen Stability

3 Days Room Temperature
Refrigerated : 2 weeks
Frozen: 1 Month

Methodology

Quantitative Radioimmunoassay/Semi-Quantitative Indirect Fluorescent Antibody
 
If VGKC is Indeterminate or Positive, LGI1 Antibody IgG and CASPR2 Antibody IgG will be added. If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.

Days Performed

TAT 2 - 9 days Set up Tuesdays

Performing Laboratory

ARUP Laboratories

CPT

83519
LOINC Code: 41871-5

PDM

1759386

Only Orderable at Locations:

Orderable Everywhere

Results
Component Name Base Name Common Name External Name
VOLTAGE-GATED K CHANNEL AB VGKCHANAB VOLTAGE GATED K CHANNEL AB Voltage-Gated K Channel Ab
CASPR2 AB IGG SCREEN BY IFA CASPR2 CASPR2 AB IGG SCREEN BY IFA CASPR2 Ab IgG Screen by IFA
CASPR2 AB IGG TITER BY IFA CASPR2 CASPR2 AB IGG TITER BY IFA CASPR2 Ab IgG Titer by IFA
LGI1 AB IGG SCREEN BY IFA LG1ABIGGSC LGI1 AB IGG SCREEN BY IFA LGI1 Ab IgG Screen by IFA
LGI1 AB IGG TITER BY IFA LG1ABIGGT LGI1 AB IGG TITER BY IFA LGI1 Ab IgG Titer by IFA

Result Interpretation

Voltage-Gated Potassium Channel (VGKC) Antibody 
                 Negative           31 pmol or less
                Indeterminate    32 - 87 pmol/L
                Positive              88 pmol/L or greater
Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to Titer
               Less than 1:10
Contactin-Associated Protein-2 Antibody, IgG with Reflex to Titer
             Less than 1:10

Forms
LAB11122 build edit