Urine Free Light Chains (Kappa and Lambda) with Ratio
Test Catalog Information
| Test Catalog Synonyms | |
| EPIC Synonyms |
Free Kappa and Lambda Light Chains, Urine BENCE - JONES PROTEINS Free Kappa/Lambda Urine FLC |
| Cerner Primary Mnemonic | Free Kappa/Lambda Urine |
| EPIC Display Name | Urine Free Light Chains (Kappa and Lambda) with Ratio |
| Allscripts (AEHR) Order Name | Free Kappa/Lambda Urine |
| Sunrise Clinical Manager (SCM) Order Name | Free Kappa and Lambda Light Chains, Urine |
| EPIC Inpatient Orderable | Yes |
| EPIC Outpatient Orderable | Yes |
| Cerner Results |
Kappa/Lambda Ratio Urine Free Lambda Urine Free Kappa Urine |
| Clinical Info |
This test is a latex-enhanced, immunoassay that provides ultrasensitive detection and quantitation of free light chains (FLCs) in serum or urine earlier than electrophoresis. It is an aid in the diagnosis and treatment of multiple myeloma, lymphocytic neoplasms, Waldenstroms macroglobulinemia, and connective tissue diseases, such as systemic lupus erythematosus. Approximately 15% of all cases of multiple myeloma produce only free kappa or lambda light chains in excess. These patients frequently show no abnormality on serum protein electrophoresis. Quite often urine is tested for the presence of these light chains, which are also called Bence Jones Proteins. However, the FLCs entering the urine are strongly influenced by renal tubular function. When clonal proliferation of plasma cells starts to develop, the FLC concentration increases in serum. Since these small particles are rapidly cleared by the renal tubules, urine tests for FLCs remain negative until the tumor mass expands, and the FLCs in serum exceed the resorptive capacity of the renal tubules. Therefore, the measurement of FLCs in serum is an alternative to less sensitive urine testing. Changing concentrations of FLCs in serum relate better to changing tumor load than to concentrations in urine. |
| Specimen Type |
Urine |
| Container |
Urine Transport |
| Collection Instructions |
Container/Tube: Plastic, leakproof container Specimen: 2 mL Urine from Random or 24 Hour collection (1.5 mL min) Transport Temperature: Refrigerated |
| Transport Instructions |
Refrigerated |
| Specimen Stability | |
| Methodology |
Turbidimetric |
| Days Performed |
Monday - Saturday |
| Performing Laboratory |
Northwell Health Laboratories |
| CPT |
83883 x 2 |
| PDM |
5905920 |
Desired Epic Build Urine Free Light Chains (Kappa and Lambda) with Ratio
| Cerner Primary Mnemonic: | Free Kappa/Lambda Urine | ||||||||||||
| PDM | 5905920 | ||||||||||||
| Informatics - Workgroup | Chemistry | ||||||||||||
| Synonyms * | Free Kappa and Lambda Light Chains, Urine BENCE - JONES PROTEINS Free Kappa/Lambda Urine FLC | ||||||||||||
| Display Name * | Urine Free Light Chains (Kappa and Lambda) with Ratio | ||||||||||||
| Order Entry Specimen Sources * | |||||||||||||
| Order Entry Specimen Types |
Urine
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| Ordering info (EPIC SmartText) | This test is a latex-enhanced, immunoassay that provides ultrasensitive detection and quantitation of free light chains (FLCs) in serum or urine earlier than electrophoresis. It is an aid in the diagnosis and treatment of multiple myeloma, lymphocytic neoplasms, Waldenstroms macroglobulinemia, and connective tissue diseases, such as systemic lupus erythematosus. Approximately 15% of all cases of multiple myeloma produce only free kappa or lambda light chains in excess. These patients frequently show no abnormality on serum protein electrophoresis. Quite often urine is tested for the presence of these light chains, which are also called Bence Jones Proteins. However, the FLCs entering the urine are strongly influenced by renal tubular function. When clonal proliferation of plasma cells starts to develop, the FLC concentration increases in serum. Since these small particles are rapidly cleared by the renal tubules, urine tests for FLCs remain negative until the tumor mass expands, and the FLCs in serum exceed the resorptive capacity of the renal tubules. Therefore, the measurement of FLCs in serum is an alternative to less sensitive urine testing. Changing concentrations of FLCs in serum relate better to changing tumor load than to concentrations in urine. | ||||||||||||
| IP Orderable | Yes | ||||||||||||
| OP Orderable | Yes | ||||||||||||
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AOEs * | |||||||||||||
| AP AOEs | |||||||||||||
| Special History | No | ||||||||||||
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| Procedure Category Change | |||||||||||||
Cerner Results
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Actual Epic build
| Procedure Id | 64634 | ||||||||||||||||||||||||
| Pdm | 5905920 | ||||||||||||||||||||||||
| Order Display Name | Urine Free Light Chains (Kappa and Lambda) with Ratio | ||||||||||||||||||||||||
| Procedure Name | KAPPA / LAMBDA LIGHT CHAINS, URINE, 24 HOUR | ||||||||||||||||||||||||
| Procedure Master Number | LAB734 | ||||||||||||||||||||||||
| Short Procedure Name | KAPPA/LAMBDA LIGHT CHAIN | ||||||||||||||||||||||||
| Category Code | 6.0 | ||||||||||||||||||||||||
| Category Code Record Name | LAB URINE ORDERABLES | ||||||||||||||||||||||||
| Synonyms | FREE KAPPA AND LAMBDA LIGHT CHAINS, URINE BENCE - JONES PROTEINS FREE KAPPA/LAMBDA URINE FLC | ||||||||||||||||||||||||
| Clinically Active | Yes | ||||||||||||||||||||||||
| Orderable | Yes | ||||||||||||||||||||||||
| Performable | Yes | ||||||||||||||||||||||||
| Filter Genomics | |||||||||||||||||||||||||
| Reference Link Url | https://labs.northwell.edu/epic/test/64634 | ||||||||||||||||||||||||
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| Default Specimen Type | Urine | ||||||||||||||||||||||||
| Specimen Type Pick List | Urine | ||||||||||||||||||||||||
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| Specimen Source Pick List | Urine, Clean Catch Urine, Catheter | ||||||||||||||||||||||||
| Specimen Source Default - Male | Urine, Clean Catch | ||||||||||||||||||||||||
| Specimen Source Default - Female | Urine, Clean Catch | ||||||||||||||||||||||||
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| Edp Ip Specimen Source | Urine, Clean Catch Catheter | ||||||||||||||||||||||||
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| Edp Op Specimen Type | Urine | ||||||||||||||||||||||||
| Derived Edp Ip Buttons S | Urine, Clean Catch | ||||||||||||||||||||||||
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| Ip Orderable | 1 | ||||||||||||||||||||||||
| Op Orderable | 1 | ||||||||||||||||||||||||
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EPIC Components (results)
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