Intended for symptomatic patients, or patients with risk factors, suspected of urinary tract infection.

MUST submit 2 separate urine specimens (one BD yellow-top urinalysis collection tube and one BD gray-top urine culture tube) For Northwell Core Lab, specimen will reflex to a routine urine culture if any one of the following criteria is present: 1. Positive nitrite 2. Positive leukocyte esterase 3. Bacteria >= Moderate 4. > 5 WBC/hpf Fo...

An important test for identifying early kidney disease in patients with diabetes or other risk factors (eg, hypertension).

Testing performed at Northwell Rapid Response Laboratories

Nipple Discharge slides should be immediately fixed in a 70% alcohol vial. All other specimens should be submitted in a ThinPrep CytoLyt vial. Exact specimen source and laterality where applicable must be selected/specified. For more specific collection instructions see the Test Compendium. Specimen vials should be labeled with patient demogra...

For use as an adjunct to culture for the presumptive diagnosis of past or current Legionella infection. This test only detects antigen from Legionella pneumophila serogroup 1. For culture, order "Legionella Culture" on a lower respiratory specimen.

This test is intended to aid in the diagnosis of both pneumococcal meningitis and pneumococcal pneumonia in conjunction with culture. This test should not be used as a test of cure. The clinical utility of this test in pediatric patients has not been determined.

Test Includes Amphetamine; barbiturate; benzodiazepines; cocaine; methadone; opiates; oxycodone/oxymorphone; phencyclidine (PCP); fentanyl; marijuana (THC) metabolite.

Northeast Regional Respiratory Allergen profile.

This test is a latex-enhanced, immunoassay that provides ultrasensitive detection and quantitation of free light chains (FLCs) in serum or urine earlier than electrophoresis. It is an aid in the diagnosis and treatment of multiple myeloma, lymphocytic neoplasms, Waldenstroms macroglobulinemia, and connective tissue diseases, such as systemic lup...

Preferred screening test for Cushing syndrome Diagnosis of pseudo-hyperaldosteronism due to excessive licorice consumption Test may not be useful in the evaluation of adrenal insufficiency

Determination of TPMT levels that may be associated with toxicity of anticancer and anti-inflammatory drugs

Detect Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma spp

Evaluation of osteoporosis and assessment of antiresorptive therapy

Aiding in detecting  in urine from patients with disseminated histoplasmosis. 

This test is intended for the in vitro qualitative detection of cytomegalovirus (CMV) DNA from urine . Results of this assay should be used in conjunction with the results of other clinical findings as an aid in the diagnosis of congenital CMV infection.

Order PDM # 5300520

Diagnosis and monitoring of inherited aminoacidurias, organic acidurias, and urea cycle defects. May be used as a follow-up confirmatory test to some abnormal newborn screen results.
Limitations

Confirming the presence of a myopathy associated with any 1 of the following disorders
-Hereditary myoglobinuria
-Phosphorylase deficiency
-Sporadic myoglobinuria
-Exertional myoglobinuria in untrained individuals
-Crush syndrome
-Myocardial infarction
-Myoglobinuria of progressive muscle disease
-Heat injury
...

Evaluation of catecholamine-secreting tumors of the adrenal medulla (pheochromocytomas) and extra-adrenal sympathetic and parasympathetic paragangliomas.

Diagnose the presence of a pheochromocytoma, neuroblastoma, and ganglioneuroblastoma

Evaluating patients suspected of having systemic mastocytosis Identification of aspirin sensitivity in patient respiratory diagnoses

Monitoring tobacco use
 
Monitoring patients on nicotine-replacement therapy for concurrent use of tobacco products

Urine organic acid testing is useful in the diagnosis and monitoring of patients with inborn errors of organic acid metabolism, inborn errors of amino acid metabolism, urea cycle defects, and defects of the mitochondrial respiratory chain.

This assay measures the red-cell concentration of 6-MMP (formed from 6-MP by thiopurine methyltransferase) and also measures the concentration of the resulting 6-TG after removal of the mono-, di-, or tri-phosphates from the various 6-thioguanine nucleotides.

Monitor exposure to copper

Detect the presence of prescribed, over-the-counter, and illicit drugs for the purpose of medical drug monitoring.

  **  Use only Quest 24-hour Urine Collection Kits specific for renal stone formation diagnosis.  ** This profile is for stone formers with a positive urine culture indicating urinary tract infection (UTI), also for recurrent stone formers or when  attending physician deems it medically necessary for the patient to have...

5-HIAA is the end product of serotonin (5-hydroxytryptophan) and tyrptophan metabolism. Patients with carcinoid tumors of the midgut, e.g., ileum, produce high concentrations of 5-HIAA. Patients with carcinoid tumors of the foregut and hindgut may produce little or no 5-HIAA or do so intermittently..

 
Detect the presence of illicit drugs, including ethanol
 

A positive urine alcohol is only indicative of recent use and cannot be used to determine impairment. This test should be restricted to monitoring patients in drug treatment programs where any alcohol use is prohibited.

Values above 10 mg/24 hours occur in carcinoid syndrome. Slight elevations also occur in nontropical sprue and after reserpine administration.

The test can detect over 176 health conditions that can be passed unknowingly from parent to child plus Fragile X.

Detection and quantitation of BK Virus (BKV) in urine stabilized in cobas® PCR Media can be used as an aid in the diagnosis and management of BK virus infections.

Clinically, the measurement ofcirculating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (pheochromocytomas, neuroblastomas, and gangliomas) and with the evaluation of orthostatic hypotension.

Screening for mast cell activation disorders including systemic mastocytosis using random urine specimens 2,3-Dinor-11beta-prostaglandin F2 alpha (2,3 BPG) is the most abundant metabolic product of prostaglandins released by activated mast cells. Systemic mastocytosis (SM) is a disease in which clonally derived mast cells accumulate in peripher...

Predicting potential for toxicity to thiopurine drugs

Preferred screening test for detection of arsenic, cadmium, mercury, and lead in random urine specimens If the total arsenic concentration is 10 mcg/L or greater, then speciation will be performed at an additional charge.

Detect use of ethanol

Pediatric testing for the evaluation of hypertension; diagnose and follow up neuroblastoma, ganglioneuroma, and ganglioneuroblastoma. Most neuroblastoma patients excrete excess HVA in 24-hour collections. If VMA and HVA are both used in work-up, up to 80% of all cases will be detected.

Available for Hospital ED only

Evaluate renal disease; monitor certain types of malignancies and AIDS  

Screening for mast cell activation disorders including systemic mastocytosis using 24-hour urine specimens 2,3-Dinor-11beta-prostaglandin F2 alpha (2,3 BPG) is elevated in the urine of patients with systemic mastocytosis (SM). This test should be used as a screening test for SM. When 2,3 BPG is used in combination with urinary leukotriene E4 ...

Screen measures 176 conditions associated with serious and prevalent inherited conditions

Study of adrenocortical-renin-angiotensin system; adrenal cortical function test; evaluate renal hypertension; diagnose Conn syndrome (primary aldosteronism); evaluate hypokalemia with hypertension

The mean urinary citrate excretion rate in patients with idiopathic calcium urolithiasis has been found to be significantly lower than that of control groups. Hypocitraturia is common in patients with urolithiasis resulting from renal tubular acidosis and in patients with enteric hyperoxaluria. Citrate excretion is low in renal insufficiency.

Investigating suspected Cushing syndrome (hypercortisolism), when a 24-hour collection is prohibitive (ie, pediatric patients). Assisting in diagnosing acquired or inherited abnormalities of 11-beta-hydroxy steroid dehydrogenase (cortisol to cortisone ratio) Diagnosis of pseudohyperaldosteronism due to excessive licorice consumption This t...

Twenty-four hour urine collections  for oxalate are indicated in patients with surgical loss of distal small intestine, especially those with Crohn's disease. The incidence of nephrolithiasis in patients who have inflammatory bowel disease is 2.6% to 10%.1

Diagnose pheochromocytoma, VMA is of value for evaluation of hypertension, diagnose and follow up neuroblastoma, ganglioneuroma, and ganglioneuroblastoma. Most neuroblastoma patients excrete excess HVA in 24-hour collections. If VMA and HVA are both used in work-up, up to 80% of all cases will be detected.
 

Detection of oxycodone and/or oxymorphone

Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions using 24-hour urine collection specimens Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation...

Detect the presence of prescribed and illicit drugs for the purpose of medical drug monitoring

Porphobilinogen levels in the urine should be measured during acute attacks of abdominal pain, extremity pain or paresthesias, tachycardia, nausea and vomiting, neurologic abnormalities, and to investigate characterized by urinary excretion of porphobilinogen and δ-aminolevulinic acid during acute attacks. Increased urinary excretion of por...

Detect use of oxycodone and/or oxymorphone, opioid analgesics

Cystinuria is an autosomal recessive disease in which dibasic amino acids, including cystine, are excreted in excess.

Vanillylmandelic acid (VMA) is the major urinary product resulting from the metabolic degradation of catecholamine, norepinephrine and epinephrine. Elevated concentrations of VMA are commonly found in cases of catecholamine secreting tumors such as pheochromocytoma, neuroblastoma, and ganglioneuroma.

Appropriate test to rule out acute intermittent porphyria (AIP) and other acute attack types of porphyrias associated with neurologic and/or psychiatric symptoms. Detect porphyrias and porphyrinurias.

First preferred test for screening for catecholamine-secreting tumors in a random urine specimen when requesting both homovanillic acid and vanillylmandelic acid Supporting a diagnosis of neuroblastoma Monitoring patients with a treated neuroblastoma

Urinary measurements are appropriate for assessing ongoing exposure to inorganic mercury.

Evaluating patients with possible inborn errors of metabolism using random urine specimens May aid in evaluation of endocrine disorders, liver diseases, muscle diseases, neoplastic diseases, neurological disorders, nutritional disturbances, renal failure, and burns Includes quantitation of the following amino acids: phosphoserine, phosphoethanol...

Diagnose cobalamin (vitamin B12) deficiency

Test Includes Coproporphyrins I and III; uroporphyrins; hepatocarboxylporphyrins; hexacarboxylporphyrins; pentacarboxylporphyrins Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute porphyrias, such as ac...

Detect use of THC, a psychoactive drug

Homovanillic acid (HVA) and other catecholamine metabolites (vanillylmandelic acid: VMA and dopamine) are typically elevated in patients with catecholamine-secreting tumors (eg, neuroblastoma, pheochromocytoma, and other neural crest tumors). HVA and VMA levels may also be useful in monitoring patients who have been treated as a result of the ab...

Aiding in the evaluation of patients at-risk for mast cell activation syndrome (eg, systemic mastocytosis, IgE-mediated allergies, or aspirin-exacerbated respiratory disease) using 24-hour urine collections

PCR test intended for the qualitative detection of RNA from Zika virus in human plasma, serum or urine (collected alongside a patient matched serum or plasma specimen).

Use to detect hemosiderinuria secondary to excess hemolysis.

Detection of Enterocytozoon bieneusi and Encephalitozoon species in fecal and urine specimens to support the clinical diagnosis of microsporidiosis This test is intended to be used for the detection of Enterocytozoon bieneusi and Encephalitozoon species DNA in fecal and urine specimens to support the clinical diagnosis of microsporidiosis. Other...

Evaluate porphyrias, including those involving deficiencies of enzymes that are needed for heme synthesis and chemical porphyrias.

A timed 24-hour urine collection is the preferred specimen for measuring and interpreting this urinary analyte. Random collections normalized to urinary creatinine may be of some clinical use in patients who cannot collect a 24-hour specimen, typically small children.

Detecting arsenic, cadmium, mercury, and lead exposure and toxicity using 24-hour urine specimen

Cystinuria is an autosomal recessive disease in which dibasic amino acids, including cystine, are excreted in excess. Cystine kidney stones account for approximately 1-3% of all kidney stones. Age of onset is often younger than with other types of kidney stones and the recurrence is approximately one-third.

Horizon provides comprehensive screening using the latest technology, including next-generation sequencing. Horizon screens for genes associated with specific inherited genetic conditions. 274 genes and variants are tested

Detect use of amphetamine class drugs Test Includes Methamphetamine; Amphetamine; Methylenedioxymethamphetamine (MDMA, Ecstasy); Methylenedioxyamphetamine (MDA)

Assessment of iodine toxicity or recent exposure when a 24-hour urine cannot be collected Monitoring iodine excretion rate as index of replacement therapy when a 24-hour urine cannot be collected

Diagnosis of arsenic intoxication in random urine specimens

Measure histamine that was released in vivo prior to collection of the specimen; evaluate possible systemic mastocytosis.

Detect presence of clonazepam

ALA is a precursor to uroporphyrin, coproporphyrin, and protoporphyrin. Concentrations of ALA are greatly increased in many patients with acute neurological forms of porphyrias and in some patients with chronic alcohol abuse.

Homovanillic acid (HVA) measurement in urine is used for screening children for catecholamine-secreting tumors such as neuroblastoma, pheochromocytoma, and other neural crest tumors and monitoring those who have had treatment for these tumors. HVA measurement is also useful to diagnose children with disorders of catecholamine metabolism such as...

Diagnosing Pompe disease, when used in conjunction with acid alpha-glucosidase enzyme activity assays and molecular genetic analysis of the GAA gene Monitoring Pompe patients on enzyme replacement therapy May support the diagnosis and monitoring of other glycogen storage disorders; however, glucotetrasaccharide (Glc4) excretion appears to b...

Detect use of opiate and opioid class drugs Please note: this test includes both Buprenorphine(Suboxone) and Fentanyl

Monitoring of compliance utilizing tramadol Detection and confirmation of the illicit use of tramadol

Detect use of benzodiazepine class drugs

Differential diagnosis of hypercalcemia

Urinary measurements are appropriate for assessing ongoing exposure to inorganic mercury.  

Arsenic is used in some pesticides and industrial applications.

Detect heroin metabolite
 
This assay is designed for pain management. It is not intended for workplace testing and does not comply with state regulatory workplace testing programs.

Detect presence of flunitrazepam, a potent sedative-hypnotic with a reputation as a “date-rape” drug.

Detect MDMA (methylenedioxymethamphetamine) and related compounds in urine

Therapeutic drug management; detect presence of ketamine

Detect use of cocaine class drugs

To assist in distinguishing whether a positive urine THC test is exclusively the result of CBD use.

This test is used to aid in the diagnosis and monitoring of patients with mucopolysacchariodoses (MPS) types I, II, III, IV, VI, and VII.

Urinary lead concentrations may be used to monitor detoxification therapy.

Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis

Detect use of cocaine, a stimulant drug

Assessment of iodine toxicity or recent exposure in a 24-hour urine collection Monitoring iodine excretion rate as index of replacement therapy

Assessment of iodine toxicity or recent exposure in a 24-hour urine collection Monitoring iodine excretion rate as index of replacement therapy

Detect use of gabapentin, an anticonvulsant and neuromodulator

Detecting toxic thallium exposure in 24-hour urine specimens

Detect presence of the kratom alkaloid mitragynine, a mood altering opioid receptor agonist, which has both stimulant and opioid effects.

Aid in evaluation of patient with allergic signs and symptoms, such as anaphylaxis. May assist when diagnosing and monitoring mast-cell activation disorders or when evaluating histamine production over a longer time frame.

Detect use of zolpidem, a non-benzodiazepine sedative/hypnotic

Detect use of buprenorphine, a semi-synthetic opioid medication

Detect use of barbiturate class drugs Cutoff = 100

Diagnosis of arsenic intoxication using 24 hour urine specimens. Total arsenic will be performed first. If the total arsenic concentration is 10 mcg/L or greater, then speciation will be performed and reported. If total arsenic is below 10 mcg/L, total arsenic will be reported as less than 10 mcg/L and speciation will not be performed.

Monitor industrial exposure to selenium

Zinc measurements are used to detect and monitor industrial, dietary, and accidental exposure to zinc. Also, zinc measurements may be used to evaluate health and monitor response to treatment.

 This test is intended for use as an aid in diagnosing congenital CMV infection for neonates  under 21 days old. It is important to note that samples from patients aged 21 days and older should continue to be ordered through the existing test, Cytomegalovirus PCR Urine.

The thiopurine methyltransferae (TPMT) and nudix hydrolase 15 (NUDT15) genes encode drug-metabolizing enzymes involved in the  metabolism of several clinically important drugs, including the immunosuppressant's azathioprine, mercaptopurine and thioguanine. 

Monitor patients for prior and ongoing exposure to aluminum.

Monitor exposure to nickel

Propoxyphene can also be measured in urine as part of a drug of abuse test.

Assessing renal tubular injury or dysfunction using random urine collections Screening for other tubular abnormalities Detecting chronic asymptomatic renal tubular dysfunction

Detect use of phencyclidine, a dissociative hallucinogen

This test is intended for the qualitative detection of RNA from the Zika virus in serum and urine from individuals meeting CDC Zika virus clinical criteria and/or CDC Zika virus epidemiological criteria.