MPL Mutation Molecular Detection
Desired Epic Build
* = editable field
| Cerner Primary Mnemonic: | HLX MPL Mutation Analysis Case |
| PDM | 1559701 |
| Informatics - Workgroup | Molpath inhouse |
| Synonyms * | HLX MPL Mutation Analysis Case MPL Mutation Analysis JAK-2 negative MPN diagnosis, JAK2 V617 negative testing MPLMUT |
| Display Name * | MPL Mutation Molecular Detection |
| Specimen Sources (combined Order Entry and Specimen Navigator) * |
Bone Marrow
|
| Specimen Types (combined Order Entry and Specimen Navigator) * |
Blood
Blood
Bone Marrow
|
| Body Fluids (types sent through AOEs) | |
| Specimen Navigator Specimen Types |
Aspirate
|
| Specimen Navigator Specimen Sources |
Isthmus
Left
Nasal
No Laterality
Right
Total
Abdomen/Peritoneum
Abscess
Adrenal
Amniotic Sac
Anus
Appendix
Axilla
Bile Duct
Bone
Bone Marrow
Brain
Breast
Bronchial
Buccal
Colon
Duodenum
Ear
Esophagus
Extranodal Lymphoid
Eye
Fallopian Tube
Gallbladder
Gingiva
Ileum
Jejunum
Joint
Kidney
Larynx
Liver
Lung
Lymph Node
Mediastinum
Meninges/Dura
Misc
Muscle
Nasopharynx
Nipple
Nose
Oropharynx/Throat
Ovary
Palate
Pancreas
Pancreatic Duct
Parathyroid
Paratubal Cyst
Pelvic
Penis
Pericardium
Pharynx
Pleura
Prostate
Rectum
Retroperitoneum
Salivary Gland
Sinus
Skin
Soft Tissue
Spleen
Stomach
Testis
Thymus
Thyroid
Tongue
Tonsil
Trachea
Uterus
Vagina
Vas Defe
|
| Specimen Navigator Short Name | MPL Mutation |
| Ordering info (EPIC SmartText) | The MPL gene is located on chromosome 1p34, it contains 12 exons. MPL mutations lead to a gain of function and receptor activation in the absence of thrombopoietin binding with constitutional activation of the JAK-STAT signaling pathway. The mutations can occur in Essential Thrombcythemia (ET) and Primary Myelofibrosis (PMF) and have not been reported in Polycythemia Vera (PV). The most common pathological variants causing gain of function in the MPL gene are located in exon 10: W515L, W515K, W515A and S505N. |
| IP Orderable (inpatient) | Yes |
| OP Orderable (outpatient) | Yes |
| AOEs * | |
| AP AOEs | |
| Special History | Yes |
| Build Comments | |
| Filter * | genetics |
| Cerner Site Restrict | |
| Cerner Results | |
Actual Epic Build 3/11/2025
| PROCEDURE ID | 115149 | ||||||||||||||||||||||||
| PDM | 1559701 | ||||||||||||||||||||||||
| ORDER DISPLAY NAME | MPL Mutation Molecular Detection | ||||||||||||||||||||||||
| PROCEDURE NAME | MPL MUTATION ANALYSIS | ||||||||||||||||||||||||
| PROCEDURE MASTER NUMBER | LAB11404 | ||||||||||||||||||||||||
| SHORT PROCEDURE NAME | MPL MUTATION ANALYSIS | ||||||||||||||||||||||||
| CATEGORY CODE | 21.0 | ||||||||||||||||||||||||
| CATEGORY CODE RECORD NAME | LAB MOLECULAR DIAGNOSTICS ORDERABLES | ||||||||||||||||||||||||
| SYNONYMS | HLX MPL MUTATION ANALYSIS CASE MPL MUTATION ANALYSIS JAK-2 NEGATIVE MPN DIAGNOSIS, JAK2 V617 NEGATIVE TESTING MPLMUT |
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| CLINICALLY ACTIVE | Yes | ||||||||||||||||||||||||
| ORDERABLE | Yes | ||||||||||||||||||||||||
| PERFORMABLE | Yes | ||||||||||||||||||||||||
| FILTER GENOMICS | Generic Genomics Procedure | ||||||||||||||||||||||||
| REFERENCE LINK URL | https://labs.northwell.edu/epic/test/115149 | ||||||||||||||||||||||||
| ORDERING INSTRUCTIONS | |||||||||||||||||||||||||
| DEFAULT SPECIMEN TYPE | Blood | ||||||||||||||||||||||||
| SPECIMEN TYPE PICK LIST | Bone Marrow Blood Aspirate |
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| SPECIMEN TYPE LIST | |||||||||||||||||||||||||
| OP SPECIMEN TYPE LIST | |||||||||||||||||||||||||
| SPECIMEN SOURCE PICK LIST | Bone Marrow Aspirate Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous Bone Marrow |
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| SPECIMEN SOURCE DEFAULT - MALE | Blood, Venous | ||||||||||||||||||||||||
| SPECIMEN SOURCE DEFAULT - FEMALE | Blood, Venous | ||||||||||||||||||||||||
| SPECIMEN SOURCE LIST | |||||||||||||||||||||||||
| OP SPECIMEN SOURCE LIST | |||||||||||||||||||||||||
| IP LAB TEST COMPONENTS FOR REPORT | HLXMPLFR:10 | ||||||||||||||||||||||||
| OP LAB TEST COMPONENTS FOR REPORT | HLXMPLFR:10 | ||||||||||||||||||||||||
| ORDER QUESTIONS | ["3045300170", "3045300171", "3045300173"] | ||||||||||||||||||||||||
| ORDER QUESTIONS RECORD NAME | NH IP HOME COLLECT DATE NH IP HOME COLLECT DAYS NH IP HOME COLLECT MEDICALLY NECESSARY |
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| INPATIENT ORDER QUESTIONS | ["3048500000"] | ||||||||||||||||||||||||
| INPATIENT ORDER QUESTIONS RECORD NAME | |||||||||||||||||||||||||
| ORDER SPECIFIC QUESTION OVERRIDE | Yes | ||||||||||||||||||||||||
| INPATIENT QUESTION OVERRIDE | |||||||||||||||||||||||||
| LOCATION RESTRICT LIST IP | |||||||||||||||||||||||||
| LOCATION RESTRICT LIST IP RECORD NAME | |||||||||||||||||||||||||
| LOCATION RESTRICT LIST INCLUDE IP | |||||||||||||||||||||||||
| LOCATION RESTRICT LIST OP | |||||||||||||||||||||||||
| LOCATION RESTRICT LIST OP RECORD NAME | |||||||||||||||||||||||||
| LOCATION RESTRICT LIST INCLUDES OP | |||||||||||||||||||||||||
| EDP AMB ORDER SPECIFIC QUESTIONS RECORD NAME | NH IP PATIENT COMPLETED CONSENT | ||||||||||||||||||||||||
| EDP IP ORDER SPECIFIC QUESTIONS RECORD NAME | NH IP PATIENT COMPLETED CONSENT | ||||||||||||||||||||||||
| EDP IP SPECIMEN SOURCE | |||||||||||||||||||||||||
| EDP OP SPECIMEN SOURCE | |||||||||||||||||||||||||
| EDP IP SPECIMEN TYPE | |||||||||||||||||||||||||
| EDP OP SPECIMEN TYPE | |||||||||||||||||||||||||
| DERIVED EDP IP BUTTONS S | |||||||||||||||||||||||||
| DERIVED EDP IP BUTTONS T | |||||||||||||||||||||||||
| DERIVED EDP OP BUTTONS S | |||||||||||||||||||||||||
| DERIVED EDP OP BUTTONS T | |||||||||||||||||||||||||
| IP ORDERABLE | 1 | ||||||||||||||||||||||||
| OP ORDERABLE | 1 | ||||||||||||||||||||||||
| STANDARD LAB COMPONENTS | |||||||||||||||||||||||||
| STANDARD LAB COMPONENTS RECORD NAME | |||||||||||||||||||||||||
| COMPONENT DATA REQUIREMENT | |||||||||||||||||||||||||
EPIC OP AOEs
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EPIC IP AOEs
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| EPIC Components (results - crosswalked through Cerner) | |||||||||||||||||||||||||