HLX MPL Mutation Analysis Case MPLMUT
Synonyms |
|
Allscripts (AEHR) Order Name |
MPL Mutation Analysis Case |
Sunrise Clinical Manager (SCM) Order Name |
MPL Mutation Analysis |
Clinical Info |
The MPL gene is located on chromosome 1p34, it contains 12 exons. MPL mutations lead to a gain of function and receptor activation in the absence of thrombopoietin binding with constitutional activation of the JAK-STAT signaling pathway. The mutations can occur in Essential Thrombcythemia (ET) and Primary Myelofibrosis (PMF) and have not been reported in Polycythemia Vera (PV). |
Specimen Type |
Blood, Bone Marrow |
Container |
Lavender Top Tube |
Collection Instructions |
Container/Tube: Lavender top (EDTA) tube |
Transport Instructions |
room temperature or at 4C with ice cold packs |
Specimen Stability |
Specimens are stable for a week refrigerated. |
Methodology |
Polymerase Chain Reaction (PCR) with capillary electrophoresis |
Days Performed |
Monday through Friday |
Performing Laboratory |
Northwell Health Laboratories - Manhasset |
CPT |
81402 |
PDM |
1559701 |
Result InterpretationAn interpretative report will be provided. |
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Forms |