HLA B27 Molecular Detection Epic Compendium
Desired Epic Build
* = editable field
| Cerner Primary Mnemonic: | HLX HLA B27 Genotype Case | ||||||||
| PDM | 238466 | ||||||||
| Informatics - Workgroup | Molpath inhouse | ||||||||
| Synonyms * | Ankylosing Spondylitis HLA-B27 Antigen HLA B27 Genotype Case HLA Antigen B27 | ||||||||
| Display Name * | HLA B27 Molecular Detection | ||||||||
| Specimen Sources (combined Order Entry and Specimen Navigator) * | |||||||||
| Specimen Types (combined Order Entry and Specimen Navigator) * |
Blood
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| Body Fluids (types sent through AOEs) | |||||||||
| Specimen Navigator Specimen Types | |||||||||
| Specimen Navigator Specimen Sources | |||||||||
| Specimen Navigator Short Name | |||||||||
| Ordering info (EPIC SmartText) | Ankylosing spondylitis (AS) is a rheumatic inflammatory disease that belongs to the group of spondyloarthropathies. Human leukocyte antigen B27 (HLA-B27) is strongly associated with AS. There has been an increasing appreciation of HLA-B27 positivity in facilitating the diagnosis of an early stage of AS. About 90% of AS patients are HLA-B27 positive, compared to 5-10% of the general population. In addition, an increased prevalence of HLA-B27 has been reported in patients with Reiter's syndrome, anterior uveitis, psoriatic arthritis, and inflammatory bowel disease. As a result, tests of HLA-B27 are a valuable adjunct in the diagnosis of these diseases. Limitations: This test does not rule out the B*27:06 and 27:09 alleles, which are not associated with spondyloarthropathies. Certain rare alleles present in less than 1 percent of the population will not be detected. Other rare, or uncharacterized alleles may occur which may lead to false positive or false negative results. | ||||||||
| IP Orderable (inpatient) | Yes | ||||||||
| OP Orderable (outpatient) | Yes | ||||||||
AOEs *
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| AP AOEs | |||||||||
| Special History | No | ||||||||
| Build Comments | |||||||||
| Filter * | genetics | ||||||||
| Cerner Site Restrict | |||||||||
| Cerner Results | |||||||||
Actual Epic Build 10/22/2025
| PROCEDURE ID | 115145 | ||||||||||||||||||||||||||||||
| PDM | 238466 | ||||||||||||||||||||||||||||||
| ORDER DISPLAY NAME | HLA B27 Molecular Detection | ||||||||||||||||||||||||||||||
| PROCEDURE NAME | HLA B27 GENOTYPING | ||||||||||||||||||||||||||||||
| PROCEDURE MASTER NUMBER | LAB11402 | ||||||||||||||||||||||||||||||
| SHORT PROCEDURE NAME | HLA B27 GENOTYPING | ||||||||||||||||||||||||||||||
| CATEGORY CODE | 21.0 | ||||||||||||||||||||||||||||||
| CATEGORY CODE RECORD NAME | LAB MOLECULAR DIAGNOSTICS ORDERABLES | ||||||||||||||||||||||||||||||
| SYNONYMS | ANKYLOSING SPONDYLITIS HLA-B27 ANTIGEN HLA B27 GENOTYPE CASE HLA ANTIGEN B27 |
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| CLINICALLY ACTIVE | Yes | ||||||||||||||||||||||||||||||
| ORDERABLE | Yes | ||||||||||||||||||||||||||||||
| PERFORMABLE | Yes | ||||||||||||||||||||||||||||||
| FILTER GENOMICS | Generic Genomics Procedure | ||||||||||||||||||||||||||||||
| REFERENCE LINK URL | https://labs.northwell.edu/epic/test/115145 | ||||||||||||||||||||||||||||||
| ORDERING INSTRUCTIONS | Ankylosing spondylitis (AS) is a rheumatic inflammatory disease that belongs to the group of spondyloarthropathies. Human leukocyte antigen B27 (HLA-B27) is strongly associated with AS. There has been an increasing appreciati on of HLA-B27 positivity in facilitating the diagnosis of an early stage of AS. About 90% of AS patients are HLA-B27 positive, compared to 5-10% of the general population. In addition, an increased prevalence of HLA-B27 has b een reported in patients with Reiter's syndrome, anterior uveitis, psoriatic arthritis, and inflammatory bowel disease. As a result, tests of HLA-B27 are a valuable adjunct in the diagnosis of these diseases. Limitations: This test does not rule out the B*27:06 and 27:09 alleles, which are not associated with spondyloarthropathies. Certain rare alleles present in less than 1 percent of the population will not be detected. Other ra re, or uncharacterized alleles may occur which may lead to false positive or false negative results. |
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| DEFAULT SPECIMEN TYPE | Blood | ||||||||||||||||||||||||||||||
| SPECIMEN TYPE PICK LIST | Blood | ||||||||||||||||||||||||||||||
| SPECIMEN TYPE LIST | |||||||||||||||||||||||||||||||
| OP SPECIMEN TYPE LIST | |||||||||||||||||||||||||||||||
| SPECIMEN SOURCE PICK LIST | Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous |
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| SPECIMEN SOURCE DEFAULT - MALE | Blood, Venous | ||||||||||||||||||||||||||||||
| SPECIMEN SOURCE DEFAULT - FEMALE | Blood, Venous | ||||||||||||||||||||||||||||||
| SPECIMEN SOURCE LIST | |||||||||||||||||||||||||||||||
| OP SPECIMEN SOURCE LIST | |||||||||||||||||||||||||||||||
| IP LAB TEST COMPONENTS FOR REPORT | HLXB27 | ||||||||||||||||||||||||||||||
| OP LAB TEST COMPONENTS FOR REPORT | HLXB27 | ||||||||||||||||||||||||||||||
| ORDER QUESTIONS | ["3045300170", "3045300171", "3045300173", "3046700000"] | ||||||||||||||||||||||||||||||
| ORDER QUESTIONS RECORD NAME | NH IP HOME COLLECT DATE NH IP HOME COLLECT DAYS NH IP HOME COLLECT MEDICALLY NECESSARY NH IP LAB PATIENT CONSENT? |
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| INPATIENT ORDER QUESTIONS | ["3046700000"] | ||||||||||||||||||||||||||||||
| INPATIENT ORDER QUESTIONS RECORD NAME | NH IP LAB PATIENT CONSENT? | ||||||||||||||||||||||||||||||
| ORDER SPECIFIC QUESTION OVERRIDE | Yes | ||||||||||||||||||||||||||||||
| INPATIENT QUESTION OVERRIDE | Yes | ||||||||||||||||||||||||||||||
| LOCATION RESTRICT LIST IP | |||||||||||||||||||||||||||||||
| LOCATION RESTRICT LIST IP RECORD NAME | |||||||||||||||||||||||||||||||
| LOCATION RESTRICT LIST INCLUDE IP | |||||||||||||||||||||||||||||||
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| LOCATION RESTRICT LIST OP RECORD NAME | |||||||||||||||||||||||||||||||
| LOCATION RESTRICT LIST INCLUDES OP | |||||||||||||||||||||||||||||||
| EDP AMB ORDER SPECIFIC QUESTIONS RECORD NAME | NH IP PATIENT COMPLETED CONSENT | ||||||||||||||||||||||||||||||
| EDP IP ORDER SPECIFIC QUESTIONS RECORD NAME | NH IP PATIENT COMPLETED CONSENT | ||||||||||||||||||||||||||||||
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| DERIVED EDP IP BUTTONS S | |||||||||||||||||||||||||||||||
| DERIVED EDP IP BUTTONS T | |||||||||||||||||||||||||||||||
| DERIVED EDP OP BUTTONS S | |||||||||||||||||||||||||||||||
| DERIVED EDP OP BUTTONS T | |||||||||||||||||||||||||||||||
| IP ORDERABLE | 1 | ||||||||||||||||||||||||||||||
| OP ORDERABLE | 1 | ||||||||||||||||||||||||||||||
| STANDARD LAB COMPONENTS | |||||||||||||||||||||||||||||||
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| COMPONENT DATA REQUIREMENT | |||||||||||||||||||||||||||||||
EPIC OP AOEs
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EPIC IP AOEs
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| EPIC Components (results - crosswalked through Cerner) | |||||||||||||||||||||||||||||||