Peds Autoimmune CNS Eval, Serum PCDES

Synonyms

Allscripts (AEHR) Order Name

Peds Autoimmune CNS Eval, Serum

Sunrise Clinical Manager (SCM) Order Name

Peds Autoimmune CNS Eval, Serum

EPIC Order Name

Pediatric Autoimmune Encephalopathy/CNS Disorder Evaluation, Serum

Clinical Info

Use for Patients under 18 years of age ( ADULTS order ENS2)
Evaluating new onset encephalopathy (noninfectious or metabolic) comprising confusional states, psychosis, delirium, memory loss, hallucinations, movement disorders, sensory or motor complaints, seizures, dyssomnias, ataxias, nausea, vomiting, inappropriate antidiuresis, coma, dysautonomias, or hypoventilation using serum specimens
The following accompaniments should increase of suspicion for autoimmune encephalopathy:
-Headache
-Autoimmune stigmata (personal or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus)'
-History of cancer
-Smoking history (20 or more pack-years) or other cancer risk factors
-Inflammatory cerebral spinal fluid (or isolated protein elevation)
-Neuroimaging signs suggesting inflammation
Evaluating limbic encephalitis (noninfectious)
Directing a focused search for cancer
Investigating encephalopathy appearing during or after cancer therapy and not explainable by metastasis or drug effect

Specimen Type

Blood

Specimen Volume

4 mL serum ( 2.5 mL min)

Container

Gold Top Tube

Collection Instructions

Container/Tube: Gold top Tube or Red Top Tube
Specimen: 4 mL serum ( 2.5 mL min)
Patient Preparation:
1. For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.
2. This test should not be requested for patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed or canceled if radioactivity remains.

Transport Instructions

Specimen Stability

3 Days Room Temperature
28 Days Refrigerated
28 Days Frozen

Methodology

Indirect Immunofluorescence Assay (IFA)
Cell Binding Assay (CBA)
Flow Cytometry
Immunoblot (IB)
Radioimmunoassay (RIA)
Medical Interpretation

Days Performed

TAT: 9-13- Days

Performing Laboratory

Mayo Medical Laboratories

CPT

86255 x 11
86341
86053
LOINC Code 101417-4

PDM

235274

Result Interpretation

Forms