Inpatient and Outpatient Orderable

Pediatric Autoimmune Encephalopathy/CNS Disorder Evaluation, Serum Build info

Synonyms

  • PEDIATRIC AUTOIMMUNE ENCEPHALOPATHY/CNS DISORDER EVALUATION, SERUM
  • PCDES
  • LAB13904

Short Name

PEDS AUTOIMMUNE CNS EVAL, SERUM

Procedure Master Number

LAB13904

Procedure ID

182694

Clinical Info

Use for Patients under 18 years of age ( ADULTS order ENS2)
Evaluating new onset encephalopathy (noninfectious or metabolic) comprising confusional states, psychosis, delirium, memory loss, hallucinations, movement disorders, sensory or motor complaints, seizures, dyssomnias, ataxias, nausea, vomiting, inappropriate antidiuresis, coma, dysautonomias, or hypoventilation using serum specimens
The following accompaniments should increase of suspicion for autoimmune encephalopathy:
-Headache
-Autoimmune stigmata (personal or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus)'
-History of cancer
-Smoking history (20 or more pack-years) or other cancer risk factors
-Inflammatory cerebral spinal fluid (or isolated protein elevation)
-Neuroimaging signs suggesting inflammation
Evaluating limbic encephalitis (noninfectious)
Directing a focused search for cancer
Investigating encephalopathy appearing during or after cancer therapy and not explainable by metastasis or drug effect

Specimen Sources

 Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

 Blood

Container

Gold Top Tube

Collection Instructions

Container/Tube: Gold top Tube or Red Top Tube
Specimen: 4 mL serum ( 2.5 mL min)
Patient Preparation:
1. For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.
2. This test should not be requested for patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed or canceled if radioactivity remains.

Transport Instructions

Specimen Stability

3 Days Room Temperature
28 Days Refrigerated
28 Days Frozen

Methodology

Indirect Immunofluorescence Assay (IFA)
Cell Binding Assay (CBA)
Flow Cytometry
Immunoblot (IB)
Radioimmunoassay (RIA)
Medical Interpretation

Days Performed

TAT: 9-13- Days

Performing Laboratory

Mayo Medical Laboratories

CPT

86255 x 11
86341
86053
LOINC Code 101417-4

PDM

 235274

Only Orderable at Locations:

 Orderable Everywhere

Results
Component Name Base Name Common Name External Name
PEDS AUTOIMMUNE CNS INTERP, S PEDSAUTOCNSI PEDS AUTOIMMUNE CNS INTERP, S Peds Autoimmune Cns Interp, S
IFA NOTES IFANOTES IFA NOTES Ifa Notes
AMPA-R ABCBA AMPARABCBA AMPA R ABCBA Ampa-R Abcba
ANNA-1, S ANNA1S ANNA 1 S Anna-1, S
CASPR2-IGG CBA, S CASPR2IGCBAS CASPR2 IGG CBA S Caspr2-Igg Cba, S
DPPX AB CBA, S DPPXABCBAS DPPX AB CBA, S Dppx Ab Cba, S
GABA-B- RECEPTOR ANTIBODY BY CBA, SERUM GABABABCBA GABA B ABCBA Gaba-B- Receptor Antibody By Cba, Serum
GLUTAMIC ACID DECARBOXYLASE ANTIBODY GADAB GLUTAMIC ACID DECARB AB
GLIAL FIBRILLARY ACIDIC PROTEIN.ALPHA SUBUNIT AB IGG GFAPIFA GLIAL FIBRILLARY ACIDIC PROTEIN ALPHA SUBUNIT AB IGG Glial Fibrillary Acidic Protein.Alpha Subunit Ab Igg
LGI1-IGG CBA, S LGI1IGGCBAS LGGI1 IGG CBA S Lgi1-Igg Cba, S
METABOTROPIC GLUTAMATE RECEPTOR 1 AB IGG MGLUR1ABIFA METABOTROPIC GLUTAMATE RECEPTOR 1 AB IGG Metabotropic glutamate receptor 1 AB IGG
MOG AB CBA, SERUM MOGABCBA MOG AB CBA, SERUM Mog Ab Cba, Serum
NEUROCHONDRIN AB NEUROCHIFA NEUROCHONDRIN AB Neurochondrin AB
NMDA-R ABCBA NMDARABCBA NMDA R ABCBA Nmda-R Abcba
NEUROMYELITIS OPTICA (NMO) AB NMOAB NEUROMYELITIS OPTICA NMO AB Neuromyelitis Optica (Nmo) Ab
PCA-TR, S PCATRS PCA TR S Pca-Tr, S