CMV Resistance-5 Antiviral Meds CMVRESIST

Synonyms
Allscripts (AEHR) Order Name	CMV Resistance-5 Antiviral Meds
Sunrise Clinical Manager (SCM) Order Name	Cytomegalovirus (CMV) Resistance-5 Antiviral Me
Clinical Info	The CMV Resistance measures: Maribavir, Letermovir, Ganciclovir, Foscarnet, Cidofovir Human Cytomegalovirus (CMV) infections are a major cause of morbidity and mortality among immunocompromised patients.
Specimen Type	Blood
Container	Lavender Top Tube
Collection Instructions	Container/Tube: Lavender (EDTA) Top Tube Specimen: 2 mL plasma (0.2 mL min) Samples must be received within 6 days of collection unless frozen
Transport Instructions	Refrigerated
Specimen Stability	7 Days room Temperature 7 Days Refrigerated 60 Days Frozen
Methodology	PCR followed by genotypic sequencing
Days Performed	TAT: 3 - 5 Days Patient outcomes depend on effective prophylaxis and treatment with antiviral therapies, including maribavir, letermovir, cidofovir, ganciclovir, valganciclovir and foscarnet. Additionally, letermovir is approved specifically for prophylactic use in hematopoietic stem cell transplant (HSCT) patients. Proper patient management requires rapid detection of resistance. Laboratory testing should be used to confirm the occurrence of drug resistance, as treatment modification based solely on clinical suspicion may result in added toxicity and increased complexity in patient management. The CMV Resistance: Maribavir, Letermovir, Ganciclovir, Foscarnet, Cidofovir sequencing assay is designed to detect identified mutations in the UL54, UL56 and UL97 genes of CMV. The use of genotypic sequencing offers a rapid turnaround time, a broad range of antiviral resistance information, and the ability to provide information concerning new drugs as they become available
Performing Laboratory	Eurofins-Viracor
CPT	87910 x 3
PDM	235701
Result Interpretation Mutations in the UL54, UL56 and UL97 genes will be reported as Resistant/None Detected. Interpretation of gene mutations and association with antiviral resistance, including maribavir, ganciclovir, foscarnet, and cidofovir and letermovir will be provided with the report Specificity CMV sequencing analysis provides information about selected locations in three genes, UL54, UL56, and UL97 involved in CMV antiviral resistance.
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