2,3-Dinor-11b-Prostaglandin F2a, RU 23BPR

Synonyms

Allscripts (AEHR) Order Name

2,3-dinor-11b-Prostaglandin F2a, Random Urine

Sunrise Clinical Manager (SCM) Order Name

2,3-dinor-11b-Prostaglandin F2a, Random Ur

EPIC Order Name

Random Urine, 2,3-Dinor 11 Beta-Prostaglandin F2 Alpha

Clinical Info

Screening for mast cell activation disorders including systemic mastocytosis using random urine specimens
2,3-Dinor-11beta-prostaglandin F2 alpha (2,3 BPG) is the most abundant metabolic product of prostaglandins released by activated mast cells. Systemic mastocytosis (SM) is a disease in which clonally derived mast cells accumulate in peripheral tissues. Degranulation of these mast cells releases large amounts of histamines, prostaglandins, leukotrienes, and tryptase.

World Health Organization diagnostic criteria for SM require the presence of elevated mast cell counts on a bone marrow biopsy and 1 of the following minor criteria: abnormal mast cell morphology, KIT Asp816Val variant, CD25-positive mast cells, or serum tryptase greater than 20 ng/mL. Alternatively, SM diagnosis can be made with the presence of 3 minor criteria in the absence of abnormal bone marrow studies.
Measurement of mast cell mediators in blood or urine is less invasive and is advised for the initial evaluation of suspected cases. Elevated levels of serum tryptase, urinary N-methylhistamine, 2,3 BPG, or leukotriene E4 are consistent with the diagnosis of systemic mast cell disease.

Specimen Type

Urine

Container

Urine Cup

Collection Instructions

Container/Tube: Urine Container
Specimen: 5 mL Random Urine (4 mL min)
Transport Temperature: Refrigerated
Stability: 8 Hours Room Temperature
14 Days Refrigerated
30 Days Frozen

Transport Instructions

Refrigerated

Specimen Stability

8 Hours Room Temperature
14 Days Refrigerated
30 Days Frozen

Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Creatinine: Enzymatic Colorimetric Assay

Days Performed

TAT: 3-7 Days

Performing Laboratory

Mayo Medical Laboratories

CPT

84150
82570
LOINC Code: 97658-9

PDM

2159269, 23BPR

Result Interpretation

Forms