Methotrexate Polyglutamates MTXPGS

Synonyms

Allscripts (AEHR) Order Name

Methotrexate Polyglutamates

Sunrise Clinical Manager (SCM) Order Name

Not Orderable

EPIC Order Name

Clinical Info

Methotrexate is an antimetabolite that combines with dihydrofolate reductase and interferes with the synthesis of tetrahydrofolic acid necessary for purines, DNA synthesis. The half-life in plasma is only several hours, while the methotrexate polyglutamates persist in cells for weeks or months.

Specimen Type

Blood

Container

Lavender Top Tube

Collection Instructions

Specimen: 4 mL whole (1 mL min).
Collection must be performed at least 36 hours after last methotrexate dose.

Transport Instructions

Refrigerated

Specimen Stability

7 Days refrigerated

Methodology

High-pressure liquid chromatography/tandem mass spectrometry (HPLC/MS-MS)
TAT: 8 - 16 Days

Days Performed

Performing Laboratory

LabCorp Burlington, NC

CPT

80204

PDM

255283

Result Interpretation

Forms


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