Methotrexate Polyglutamates MTXPGS

Synonyms

Allscripts (AEHR) Order Name

Not Orderable

Sunrise Clinical Manager (SCM) Order Name

Not Orderable

EPIC Order Name

Clinical Info

Methotrexate is an antimetabolite that combines with dihydrofolate reductase and interferes with the synthesis of tetrahydrofolic acid necessary for purines, DNA synthesis. The half-life in plasma is only several hours, while the methotrexate polyglutamates persist in cells for weeks or months.


Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Type

Blood

Container

Lavender Top Tube

Collection Instructions

Container/Tube: Lavender EDTA Top Tube
Specimen: 4 mL whole (1 mL min)
Transport Temperature: Refrigerated
Stability: 7 Days refrigerated

Transport Instructions

Refrigerated

Specimen Stability

7 Days refrigerated

Methodology

High-pressure liquid chromatography/tandem mass spectrometry (HPLC/MS-MS)
TAT: 8 - 16 Days

Days Performed

Performing Laboratory

LabCorp Burlington, NC

CPT

80204

PDM

2159004

Result Interpretation

Forms