Methotrexate Polyglutamates

Synonyms

LAB14610
METHOTREXATE POLYGLUTAMATES

Cerner Name

Clinical Info

Methotrexate is an antimetabolite that combines with dihydrofolate reductase and interferes with the synthesis of tetrahydrofolic acid necessary for purines, DNA synthesis. The half-life in plasma is only several hours, while the methotrexate polyglutamates persist in cells for weeks or months.

Specimen Sources

Blood, Arterial Blood, Capillary Blood, Central Line Blood, Venous

Specimen Types

Blood

Specimen Volume

4 mL whole (1 mL min)

Container

Lavender Top Tube

Collection Instructions

Specimen: 4 mL whole (1 mL min).
Collection must be performed at least 36 hours after last methotrexate dose.

Transport Instructions

Refrigerated

Specimen Stability

7 Days refrigerated

Methodology

High-pressure liquid chromatography/tandem mass spectrometry (HPLC/MS-MS)
TAT: 8 - 16 Days

Days Performed

Performing Laboratories

LabCorp Burlington, NC

CPT

80204

PDM

255283

Results

Component Name	Base Name	Common Name	External Name
METHOTREXATE PG TOTAL	MTXPG	METHOTREXATE PG TOTAL	Methotrexate PG Total
METHOTREXATE PG1 (PARENT DRUG)	MTXPG	METHOTREXATE PG1	Methotrexate PG1 (parent drug)
METHOTREXATE PG2	MTXPG	METHOTREXATE PG2	Methotrexate PG2
METHOTREXATE PG3	MTXPG	METHOTREXATE PG3	Methotrexate PG3
METHOTREXATE PG4	MTXPG	METHOTREXATE PG4	Methotrexate PG4
METHOTREXATE PG5	MTXPG	METHOTREXATE PG5	Methotrexate PG5
METHOTREXATE INTERPRETATION	MTXPG	METHOTREXATE INTERPRETATION	Interpretation

Result Interpretation

Forms

Chemistry LAB14610

Search: .supercomplete-item { width: 600px; white-space: nowrap; overflow: hidden; text-overflow: ellipsis; } $(document).ready(function() { $("#search_input").supercomplete(); });