ADmark Phospho-Tau/Total-TA TAUCSF

Synonyms

Allscripts (AEHR) Order Name

ADmark Phospho-Tau/Total-TA

Sunrise Clinical Manager (SCM) Order Name

Admark Alzheimer Eval, CSF

EPIC Order Name

CSF, ADmark Phospho-Tau/Total-Tau/A Beta42, Analysis and Interpretation (Symptomatic)

Clinical Info

Admark® Alzheimer's Evaluation, CSF (FDA Cleared) - Elecsys Beta Amyloid (1 42) CSF II, Phospho-Tau (181P) CSF and Elecsys Total Tau CSF are in vitro electrochemiluminescence immunoassays for the measurement of the Beta Amyloid (1 42) (Abeta42), PTau (181P) and Total Tau (tTau) protein concentration in cerebrospinal fluid (CSF) from adult patients aged 55 years and older being evaluated for Alzheimer's disease (AD) and other causes of cognitive impairment to generate a tTau/Abeta42 and pTau-181/Abeta42 ratios and values. A negative result, defined as tTau/Abeta42 and Phospho-Tau (181P) ratio values below cutoff or an Abeta42 value above the measuring range, are consistent with a negative amyloid positron emission tomography (PET) scan result. A negative result reduces the likelihood that a patient?s cognitive impairment is due to AD. A positive result, defined as tTau/Abeta42 and pTau181/Abeta42 ratio value above cutoff, is consistent with a positive amyloid PET scan result. A positive result does not establish a diagnosis of AD or other cognitive disorder. The tTau/Abeta42 and pTau181/Abeta42 ratio results are used as an adjunct to other clinical diagnostic evaluations.

Specimen Type

CSF

Specimen Volume

1 mL CSF ( 0.7 mL min)

Container

Sarstedt CSF Low protein-binding polypropylene Tube (Order number: 63.614.625)

Collection Instructions

Do not process the CSF sample before transport to the measuring site (i.e., no mixing/inverting, no tube transfers, no aliquoting, no freezing and normally no centrifugation) until measurement.
Specimen Reject Criteria:
1: CSF samples collected in non-polypropylene tubes
2: CSF specimens with gross hemolysis

Transport Instructions

Refrigerated

Specimen Stability

Room temperature: 5 days
Refrigerated: 14 days
Frozen: 56 days

Methodology

Electrochemiluminescence (ECLIA)

Days Performed

TAT: 3-5 Days

Performing Laboratories

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

CPT

84393
82234
84394

PDM

2159034

Result Interpretation

Forms