Paraneoplastic Evaluation PARAN

Synonyms

Allscripts (AEHR) Order Name

Paraneoplastic Evaluation, Serum

Sunrise Clinical Manager (SCM) Order Name

Paraneoplastic Autoantibody Evaluation, Serum

EPIC Order Name

Paraneoplastic Autoantibody Evaluation, Serum

Clinical Info

Serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, 
especially those with known risk factors for cancer
Directing a focused search for cancer
Investigating neurological symptoms that appear during, or after, cancer therapy and are not explainable by metastasis
Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy
Monitoring the immune response of seropositive patients during cancer therapy
Detecting early evidence of cancer recurrence in previously seropositive patients

Specimen Type

Blood

Container

Gold Top Tube

Collection Instructions

Container/Tube: Red top tube or Gold Top Tube
Specimen : 4 mL serum (2 mL min)
Transport Temperature: Refrigerated
Patient Preparation:
1. For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication 
or intravenous immunoglobulin treatment.
2. This test should not be requested for patients who have recently received radioisotopes, therapeutically or diagnostically, 
because of potential assay interference.
 The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the 
clearance rate in the individual patient. 
Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 
1 week and assayed if sufficiently decayed or canceled if radioactivity remains.

Transport Instructions

Refrigerated

Specimen Stability

3 days Room Temperature
28 Days Refrigerated or Frozen

Methodology

Indirect Immunofluorescence Assay (IFA)
Radioimmunoassay (RIA)
Western Blot (WB)
Immunoblot (IB)
Cell-Binding Assay (CBA)

Days Performed

TAT: 11-18 Days

Performing Laboratory

Mayo Medical Laboratories

CPT

83516
86596
86255 x 9
LOINC Code: 43104-9

PDM

5910633

Result Interpretation

Test ID	Reporting name	Methodology*	Reference value
PAINT	Interpretive Comments	Medical interpretation	Not applicable
AMPHS	Amphiphysin Ab, S	IFA	Negative
AGN1S	Anti-Glial Nuclear Ab, Type 1	IFA	Negative
ANN1S	Anti-Neuronal Nuclear Ab, Type 1	IFA	Negative
ANN2S	Anti-Neuronal Nuclear Ab, Type 2	IFA	Negative
ANN3S	Anti-Neuronal Nuclear Ab, Type 3	IFA	Negative
CRMS	CRMP-5-IgG, S	IFA	Negative
VGKC	Neuronal (V-G) K+ Channel Ab, S	RIA	< or =0.02 nmol/L
CCPQ	P/Q-Type Calcium Channel Ab	RIA	< or =0.02 nmol/L
PCABP	Purkinje Cell Cytoplasmic Ab Type 1	IFA	Negative
PCAB2	Purkinje Cell Cytoplasmic Ab Type 2	IFA	Negative
PCATR	Purkinje Cell Cytoplasmic Ab Type Tr	IFA	Negative

Reflex Tests:

Forms